A freeze drying vessel having a drying chamber and moveable transfer belts each moved by a driven drum. Each transfer belt includes a transfer surface that transports frozen particles. Each transfer surface is arranged vertically in the chamber and moves in an opposite direction than a lower transfer surface. A removal device is located adjacent each driven drum that removes frozen particles from an end of each transfer surface, respectively, to enable removed frozen particles to flow downward to a lower transfer surface. A heating element is located adjacent each transfer belt to sublimate the frozen particles to form freeze dried product.

A freeze dryer processes aseptic bulk powder products. The freeze dryer freezes the product by mixing an atomized spray of product with sterile liquid nitrogen to produce a frozen powder. The frozen powder is freeze dried in a vessel by dielectrically heating the frozen powder using electromagnetic radiation such as microwave radiation or infrared radiation, and the frozen powder is continuously agitated using a sterilizable apparatus such as a series of vibrating shelves to maintain even heating and to prevent agglomeration.

A convection current vacuum freeze drying apparatus is disclosed which includes a dryer chamber unit comprising a plurality of trays for depositing products to be freeze dried; a convection current condenser unit, mechanically connected to the dryer chamber unit, comprising a plurality of first elongate heat exchange tubes each having fins arranged around an outer circumference of the first elongate heat exchange tube; a refrigerator unit mechanically connected to the convection current condenser unit, operable to provide cold temperature to the plurality of elongate heat exchange tubes; a cooling tower unit mechanically connected to the convection current condenser unit; a primary vacuum pump unit, mechanically connected to the convection current condenser unit and the cooling tower unit, operable to provide a vacuum pressure to said convection current condenser unit; and a heater unit mechanically connected to provide a heat energy to both the dryer chamber unit and the convection current condenser unit.

A process for the production of a device for dispensing eye drops. The process includes the steps of providing a first container and a second container configured to be engaged in a fluid-tight manner, providing a spacer, introducing a water-based solution inside the first container, introducing a solution or dispersion comprising a drug inside the second container, arranging the spacer between the first and second containers, engaging in a fluid-tight manner the second container and the first container, and freeze-drying the solution or dispersion comprising the drug.

A method for the production of freeze-dried pellets comprising factor VIII comprises the steps of: a) freezing droplets of a solution comprising factor VIII to form pellets; b) freeze-drying the pellets; wherein in step a) the droplets are formed by means of droplet formation of the solution comprising factor VIII into a cooling tower which has a temperature-controllable inner wall surface and an interior temperature below the freezing temperature of the solution and wherein in step b) the pellets are freeze-dried in a rotating receptacle which is housed inside a vacuum chamber.

A double-sealing type apparatus for collecting spray freeze ice ball particles and a collecting method for the double-sealing type apparatus are provided. The double-sealing type apparatus includes a collector, a collecting trolley, a vacuum pumping device, a heating device, a first sealing pad and a second sealing pad. The collector is arranged on the collecting trolley, and is provided with a collecting port. The collecting port corresponds to a discharging port at the bottom of a freezing tower. A water inlet is further provided at the collecting port, and the water inlet is in communication with a space formed by the aligning of the collecting port and the discharging port. Good sealing performance is achieved in a double-sealing manner including the sealing pads and the ice sealing, so as to smoothly transfer ice balls in the freezing tower.

A solid colorant including a. 30-97 wt % of a pigment, b. less than 5 wt % of a solvent c. 3-40 wt % surfactants and wherein: the ratio S/A [Std dev of the particle size distribution/average particle size] of the solid colorant is <25%, preferably <22% and more preferably <20%, wherein wt % is relative to the total weight of the solid colorant, and wherein the particle size distribution is determined with light scattering with fully automated image analysis according to ISO 13322-1 Static image analysis First edition 2004 Dec. 1 by the use of the OCCHIO ZEPHYR ESR analyzer. A process for making the solid colorant, and the use of the solid colorant for tinting base paints by volumetric dosing of the solid colorant to the base paint.

Assemblies, systems, and methods for preventing contamination and alteration of a biological material during and after freeze-drying processes are disclosed. Tray assemblies configured to hold the biological material in a container during a freeze-drying process include a tray and complementary lid. The lid can include compressible leg members configured to transition from an extended configuration to a compressed configuration in response to a downward force applied against the lid when the lid is positioned above the tray. A gap exists between an upper edge of the tray and an underside of the lid when the leg members are extended. With the legs extended and the tray assembly open, the tray assembly is freeze-dried. After freeze-drying is complete, the legs can be compressed and the lid sealed against the tray, enclosing the biological material within the assembly, and protecting it from contamination and ambient air exposure within and outside the chamber.

The disclosure relates to ultrahigh efficiency spray drying systems and processes, utilizing induction of localized turbulence in a drying fluid flow stream to produce spray dried product, having particular utility for low temperature spray drying operations. In a specific implementation, a method of processing a spray dryable liquid composition to form a spray dried product includes the steps of: generating a spray of the spray dryable liquid composition; contacting the spray of spray dryable liquid composition in a spray drying contact zone with a stream of primary drying fluid; injecting pressurized secondary drying fluid into the stream of primary drying fluid in the spray drying contact zone at multiple loci thereof to provide localized turbulence at said multiple loci; and recovering the spray dried product from the spray drying contact zone. Systems of the present disclosure are effective in achieving high-rate production of dry powder spray dried products, with substantially reduced capital equipment costs, energy requirements, and operating expenditures.

A method for producing powdered quinoa. The method includes dehulling quinoa in a dehuller in some embodiments. The quinoa is dried in a dryer in some embodiments. The quinoa is soaked in a soaker and freeze dried in a freeze dryer. In certain embodiments, the quinoa is extruded on an extruder. In one embodiment, the quinoa is ground in a grinder.