This disclosure provides compositions and methods for improving erythrocyte dysfunction or treating a hemoglobinopathy or a thalassemia (e.g., sickle cell disease or β-thalassemia).

This disclosure provides compositions and methods for improving erythrocyte dysfunction or treating a hemoglobinopathy or a thalassemia (e.g., sickle cell disease or β-thalassemia).

The present invention aims to provide a composition for sleep improvement, which contains a highly safe substance as an active ingredient, and a method of improving sleep. The present invention relates to, for example, a composition for sleep improvement, which contains L-ergothioneine or a salt thereof as an active ingredient.

The present invention aims to provide a composition for sleep improvement, which contains a highly safe substance as an active ingredient, and a method of improving sleep. The present invention relates to, for example, a composition for sleep improvement, which contains L-ergothioneine or a salt thereof as an active ingredient.

Among others, the present disclosure provides methods for extending lifespan or improving healthspan in a mammal, which includes administration to the mammal of a composition containing an effective amount of ergothioneine, or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof.

Among others, the present disclosure provides methods for extending lifespan or improving healthspan in a mammal, which includes administration to the mammal of a composition containing an effective amount of ergothioneine, or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof.

Disclosed herein is disclosed is a nutritional food product (supplement) comprising creatine, which may be provided in a gummy form. In certain embodiments, the supplement may comprise about 6% to 35% by weight of creatine. In some embodiments, the supplement may comprise a gelling agent, a sweetener, and water.

Disclosed herein is disclosed is a nutritional food product (supplement) comprising creatine, which may be provided in a gummy form. In certain embodiments, the supplement may comprise about 6% to 35% by weight of creatine. In some embodiments, the supplement may comprise a gelling agent, a sweetener, and water.

According to the present invention, a composition that has high safety, can be continuously used for a long period, promotes production of VEGF and FGF7 involved in hair growth, and affords good prophylactic or improving effect on thinning hair or hair loss can be provided. The present invention relates to a composition for promoting hair thickening, containing one or more members selected from the group consisting of citrulline, tryptophan, glutamine, and ornithine, a composition for maintaining the anagen phase in the hair cycle and a composition for promoting VEGF production, each containing one or more members selected from the group consisting of citrulline, tryptophan, and glutamine, a composition for promoting transition from the telogen phase to the anagen phase in the hair cycle and a composition for promoting FGF7 production, each containing ornithine, and a composition for promoting normalization of the hair cycle, containing one or more members selected from the group consisting of citrulline, tryptophan, glutamine, and ornithine.

The present invention includes a composition and method of producing aspirin in situ, the method comprising: identifying a subject in need of aspirin or aspirin-like compounds; and providing the subject with a composition comprising: a source of methyl salicylate, an acetyl donor, and L-Arginine, wherein the composition is effective to produce aspirin-triggered resolvins in the subject without the deleterious effect of the aspirin or aspirin-like compounds in the stomach.