An implantable body fluid drainage system includes a metering shunt having a housing with an internal chamber. A movable barrier divides the chamber into a first section and a second section, and the barrier can be displaced by a differential pressure. A first powered inlet valve providing a fill path to the first section of the chamber, and a first powered drain valve providing a drain path from the first section of the chamber. A CSF inlet conduit connects a CSF space to the first powered inlet valve. A CSF outlet conduit connects the first powered outlet valve to a discharge location. A controller opens the first powered inlet valve and close the first powered drain valve to fill the first section to a volume defined by the barrier and chamber geometry and closes the first powered inlet valve and opens the first powered drain valve to discharge the filled volume from the first section through the outlet conduit.

Disclosed are examples of valve systems and methods of operating the respective valve systems. An example valve system may include a valve body, an inlet component, an outlet component and a valve tube. The valve body may include a first void and a second void. The inlet component may be coupled to the first void and the outlet component may be coupled to the second void. The valve tube may include a side port and may be positioned through the valve body and coupled to the first void, the inlet component, the second void, and the outlet component. Other valve system examples may include including a valve body, a first septum, a second septum, a first piston, a second piston and a tube. The disclosed methods describe the interaction of the respective components of the respective valve system example.

A miniature transportation device is disclosed and includes a gas inlet plate, a resonance plate and a piezoelectric actuator, which are stacked on each other sequentially. The gas inlet plate comprises at least one inlet, at least one convergence channel and a convergence chamber. The convergence channel is in fluid communication with the inlet and the convergence channel. The resonance plate comprises a central aperture. A chamber gap is formed between the resonance plate and the piezoelectric actuator to define a first chamber. When the piezoelectric actuator is enabled, the gas is fed into the miniature gas transportation device through the inlet of the gas inlet plate, converged to the convergence chamber through the convergence channel, transferred through the central aperture of the resonance plate, introduced into the first chamber, and transferred along a transportation direction through a vacant space of the piezoelectric actuator to be discharged continuously.

A fluidic system includes a fluid distribution network, and a fluid collection and sampling network; a plurality of fluidic modules fluidically coupled between the fluid distribution network and the fluid collection and sampling network in parallel; a systemic circulation and mixing reservoir; and a first pump, and a second pump, wherein the first pump is fluidically coupled between the systemic circulation and mixing reservoir and the fluid distribution network for withdrawing media from the systemic circulation and mixing reservoir and delivering the media to the fluid distribution network; and wherein the second pump is fluidically coupled between the fluid collection and sampling network and a sample vial for withdrawing effluent of the plurality of fluidic modules from the fluid collection and sampling network and delivering the effluent to one or more sample vials.

The invention relates to a valve, in particular for a device for administering a liquid medicament, with a valve body (1) which has an interior (2) for receiving a liquid (20), wherein the valve body (1) has a liquid inlet (3) and an opposite liquid outlet (4) which both open into the interior (2), wherein the interior (2) accommodates a large number of micro channels (5) which extend in connection direction (x) between the liquid inlet (3) and the liquid outlet (4). A corresponding device for administering a liquid medicament is also described.

The microfluidic devices and systems disclosed herein reduce sample loss and help decrease sample processing bottlenecks for applications such as next generation sequencing (NGS). The microfluidic devices include a plurality of reaction modules. Each reaction module may comprise one or more reaction circuits. Each reaction circuit may comprise a single reaction flow channel with each reaction circuit connected by a bridge flow channel. Alternatively, each reaction circuit may comprise two or more reaction flow channels connected by two or more bridge flow channels. The combination of any two bridge flow channels and a portion of the two or more reaction flow channels between the any two bridge flow channels defining may define the reaction circuit. The reaction module may be arranged as nodes connected by bridge flow channels or each reaction module may be arranged in a parallel fashion on the microfluidic device.

The disclosed computer-implemented method may include a fluidic device comprising a chamber, an inlet port coupled to the chamber and configured to convey fluid to the chamber, and an outlet port coupled to the chamber and configured to convey the fluid from the chamber. The fluidic device may also have a restricting region that (1) is dimensioned to restrict a flow of the fluid through the outlet port when the pressure in the chamber is below a threshold level and (2) is configured to move in a manner that allows a flow rate of the fluid through the outlet port to increase when pressure in the chamber reaches the threshold level.

An integrated system for processing and preparing samples for analysis may include a microfluidic device including a plurality of parallel channel networks for partitioning the samples including various fluids, and connected to a plurality of inlet and outlet reservoirs, at least a portion of the fluids comprising reagents, a holder including a closeable lid hingedly coupled thereto, in which in a closed configuration, the lid secures the microfluidic device in the holder, and in an open configuration, the lid is a stand orienting the microfluidic device at a desired angle to facilitate recovery of partitions or droplets from the partitioned samples generated within the microfluidic device, and an instrument configured to receive the holder and apply a pressure differential between the plurality of inlet and outlet reservoirs to drive fluid movement within the channel networks.

A method for manufacturing at least one micromechanical device includes: providing a first and a separate second substrate, each having two surfaces spaced parallel to each other with a predetermined thickness; patterning a first trench structure into one of the two surfaces of the first substrate, and a second trench structure into one of the two surfaces of the second substrate; arranging the patterned surfaces of the two substrates with respect to each other such that a substrate stack with an upper and a lower surface is defined and the first and/or second trench structure forms at least one cavity therein; thinning the substrate stack from its upper and/or lower surface; exposing the at least one cavity by patterning a recess into the upper and/or lower surface of the substrate stack, wherein exposing the at least one cavity is performed after arranging the two substrates into the substrate stack.

Further embodiments relate to a valve manufactured by means of the method and to a micromechanical pump.

The valve plate (1) with free micro-balls allows a fluid (2) to flow from an upstream volume (3) to a downstream volume (4) and not in the reverse direction, and comprises a circulation plate (5) crossed through by a circulation orifice (6) terminated by a micro-ball seat (7), a permeable guide plate (9) parallel to said plate (5) being crossed through by a guide cylindrical orifice (10) which houses a micro-ball (8) which rests on said seat (7) so as to close said orifice (6) or rests on a permeable micro-ball stop abutment (11), a spacer (12) being interposed between said plate (9) and said plate (5), a discharge passageway (13) crossing through said plate (9) to allow the fluid (2) to flow when the micro-ball (8) does not rest on said seat (7).