The present invention was made in view of an object to produce a novel proteoglycan-containing material, and find a novel use and/or a superior effect of the proteoglycan-containing material. The present invention provides a proteoglycan-containing material obtained from fish cartilage, wherein the proteoglycan-containing material comprises an acidic saccharide component having a molecular weight of not less than 2000 kDa. The proteoglycan-containing material provides advantageous effects for skin-moisturizing and skin anti-aging, including a superior skin fibroblast proliferation effect, an effect of enhancing and improving the skin barrier function, an effect of enhancing and improving the skin's capability to produce collagen, a dermis-thickening inhibition effect, and the like.

Protein formulations with high protein content are included. Also included are methods of using the provided protein formulations.

Protein formulations with high protein content are included. Also included are methods of using the provided protein formulations.

Protein formulations with high protein content are disclosed. Also disclosed are methods of using the provided protein formulations.

Protein formulations with high protein content are disclosed. Also disclosed are methods of using the provided protein formulations.