Disclosed herein is an inhalable composition, suitable for use in an electronic cigarette device, comprising at least 1 g/L of nicotine and carbon dioxide dissolved or dispersed in a solvent.

Aerosol generating material for inclusion in an aerosol provision system, such as an apparatus for heating aerosol generating material to volatize at least one component thereof, the aerosol generating material including an active substance and a volatile component incorporated by infusion. The invention also relates to methods for preparing such compositions and apparatus including such materials.

Abnormally-shaped tobacco granules are provided. The tobacco granules comprise a tobacco granule body and a coating attached to the surface of the tobacco granule body. The coating contains an adhesive. The surface of the abnormally-shaped tobacco granule has one or more grooves and/or ridges, and/or, the abnormally-shaped tobacco granule has through holes therein. The surface grooves of the abnormally-shaped tobacco granules can serve as smoke channels after the tobacco granules are bonded, cured and shaped, so that the air permeability inside a total-granule tobacco product is greatly improved. The smoking resistance of cigarettes is reduced. The flammability of cigarettes is improved and the consumption of tobacco raw materials is reduced. A preparation method of the abnormally-shaped tobacco granules, a tobacco product comprising the abnormally-shaped tobacco granules, and a preparation method thereof are also provided.

There is provided an oral smokeless moist snuff product comprising: (a) an oral smokeless moist snuff composition comprising: —disintegrated plant material, —one or more salts selected from the group consisting of sodium chloride, sodium carbonate, potassium carbonate, sodium sulphate, potassium sulphate, sodium lactate, potassium lactate and any combination thereof, and —water, wherein the total amount of the one or more salts is within the range of from about 15% by weight to about 35% by weight based on the total weight of water and total weight of the one or more salts in the oral moist smokeless snuff composition, wherein the total amount of moisture is within the range of from about 35% by weight to about 60% by weight based on the total weight of the oral smokeless moist snuff composition; (b) particles comprising a flavorant and a cellulose-derivatized polymer selected from the group consisting of hydroxypropyl methylcellulose, hydroxypropyl cellulose, methyl cellulose and any combination thereof, wherein the amount of said particles is within the range of from about 1% by weight to about 25% by weight based on the total weight of the oral smokeless moist snuff product.

An aerosol-generating article is provided, including: a substrate portion containing an aerosol-forming substrate; and a connect portion disposed at one end of the aerosol-generating article in direct abutment with the substrate portion, the connect portion having a tubular empty core structure, the substrate portion having a length of between 20 millimeters and 60 millimeters, and a diameter of between 4 millimeters and 7 millimeters, the aerosol-forming substrate including an aerosol former, and an amount of the aerosol former ranges between 6 percent and 20 percent by weight on a dry weight basis of the aerosol-forming substrate. An aerosol-generating system including the aerosol-generating article and an aerosol-generating device, and a method for manufacturing the aerosol-generating article, are also provided.

Provided are methods and compositions for reducing a throat irritation caused by inhaling vapors or particles of at least one material selected from the group consisting of cannabis, cannabinoids, tobaccO, a herb or combinations thereof, the method comprising administering to a subject in need thereof at least one transient receptor potential (TRP) channel modulator prior to or simultaneously with said inhaling said vapors or particles of said at least one material. Further provided are methods and compositions comprising at least one TRP channel agonist, and/or at least one TRP channel partial agonist for treating pain-selective analgesia via TRP channels; methods for treating local pain; methods for treating migraine and symptoms thereof; and methods for treating osteoporosis and symptoms thereof.

A method for preparing a wetted vaping product for use with a vaping device includes providing dried leaf matter having been dried to remove moisture content therefrom; one of wetting, soaking, and immersing the dried leaf matter in a solvent; rehydrating the leaf matter with the solvent to increase overall weight of the dried leaf matter at least 5% to 10%; and sizing the leaf matter before and/or after the act of wetting, soaking, and immersing to fit within the vaping device. Another method includes providing leaf matter containing plant oil; mixing the leaf matter and a liquid solvent by immersing and/or soaking the leaf matter with the liquid solvent in a sterile container for at least 30 days; extracting liquid from the mixture of leaf matter and the liquid solvent; and filtering the separated liquid to remove the leaf matter of 3.5 microns to larger from the separated liquid.

The disclosure provides an effervescent composition adapted for oral use, the composition including an effervescent material; one or more fillers in a total amount of at least about 30% by weight, the one or more fillers including at least one sugar alcohol; at least one active ingredient; and optionally, a lipid in an amount of at least about 20% by weight. Melting effervescent compositions are also provided, which include the lipid.

A heated aerosol-generating article including a rod of aerosol-generating substrate is provided, the rod of aerosol-generating substrate including: a first plug of homogenised tobacco material including an aerosol former; and a second plug of homogenised tobacco material including an aerosol former, where the first plug and the second plug are coaxially aligned in an abutting end-to-end relationship, the first plug being disposed downstream of the second plug, where the first plug and the second plug differ from each other in at least one of density and composition of aerosol former, such that the first plug has a lower activation temperature than the second plug, and where, upon heating of the aerosol-generating substrate, the first plug releases aerosol after a shorter time than the second plug.

There is provided a vaporizable formulation comprising (i) one or more solvents; and (ii) less than about 1 wt % of a cooling agent based on the weight of the vaporizable formulation; wherein the cooling agent volatilizes at a higher temperature than menthol at atmospheric pressure. There is also provided a vaporizable formulation comprising (i) one or more solvents; and (ii) less than about 12 wt % of a cooling agent based on the weight of the vaporizable formulation; wherein the cooling agent volatilizes at a higher temperature than menthol at atmospheric pressure and is a compound of formula (I) or a salt and/or solvate thereof as defined herein.