A tire inflation control system for a vehicle includes: a manifold, an actuator, a pressure sensor, and an electronics module. The manifold defines: a channel for connection to a fluid source, a discharge port, an electrical connector housing configured to selectively couple to an external wiring harness. The actuator selectively controls fluid communication between the channel and the discharge port. The pressure sensor is configured to measure a fluid pressure in the discharge port. The electronics module has a multi-conductor interface with a plurality of conductors that extend to the electrical connector housing to provide connection to one or more external systems, and is in communication with the pressure sensor to command the actuator to selectively control fluid communication between the channel and the discharge port based on the pressure in the discharge port, to thereby control inflation of one or more tires connected to the discharge port.