A device for preparing a solution from a sample and a reagent, the device includes a microfluidic array having a sample supply inlet, a reagent supply inlet, a discharge outlet, a solution collection outlet, a sampling zone to which the inlets are connected, first and second preparation chambers connected to the sampling zone, arranged to either side of the sampling zone such that the liquid flowing from one preparation chamber to the other flows through the first sampling zone, the first preparation chamber having a volume that is variable between a minimum volume and a calibrated volume. The device includes valves interrupting the flow of the fluid at least at the two inlets and the collection and discharge outlets.

The present disclosure provides a dosing cap. In an embodiment, the dosing cap includes (A) a collar member having an annular skirt depending from a base. An inner surface of the annular skirt has a securing member for securing the collar member to a neck of a container. The base includes (i) at least one opening with a one-way valve permitting fluid flow in a first direction, and (ii) an air channel with a one-way valve permitting fluid flow in a second direction. The dosing cap includes (B) a cap member having an annular sidewall extending from a dispensing element. An inner surface of the annular sidewall has an attachment member adjustably attached to a reciprocal attachment member on an outer surface of the first sidewall. The dosing cap includes (C) a metering chamber formed by an enclosed volume between the cap member and the base. The dosing cap includes (D) the dispensing element permitting flow of a fluid from the metering chamber.

A dual chamber bottle includes a doser for mixing and dispensing two liquids. The bottle holds a first bulk liquid in a bulk chamber. The bottle holds a second additive liquid in a cartridge. The first and second liquid are segregated from each other. The doser is provided to dose the additive liquid into the bulk liquid. The second liquid is an additive that enhances a quality of the first liquid. The bulk chamber can be squeezed to dispense the bulk liquid out of the bottle while introducing the additive liquid to the bulk liquid in the process of dispensing.

Aspects of the present disclosure relate to evaporation compensation in fluidic devices. An example apparatus for evaporation compensation includes an assessment circuit to determine an amount of evaporation of a volume dispensed in a microwell of a fluidic device. The amount of evaporation may be determined based on the volume in the microwell, and an amount of time after dispensing the volume in the microwell. A compensation circuit may determine, based on the amount of evaporation, a compensation factor for the microwell including an amount of a normalizing fluid to compensate for the amount of evaporation. The compensation circuit may also create a normalization profile for the fluidic device, including an association between the fluidic device and the compensation factor. A dispensing circuit may dispense the normalizing fluid in the microwell according to the normalization profile.

An analyzer system includes a cartridge configured to receive a sample. The cartridge has a plurality of chambers for isolating a target analyte of the sample and collecting a quantity of a first label that is proportional to a quantity of the target analyte in the sample. The system includes an analyzer with a first electromagnetic radiation source a first detector and a controller. The first electromagnetic radiation source is configured to provide electromagnetic radiation to form an interrogation space within a detection chamber of the cartridge. The first detector is configured to detect electromagnetic radiation emitted in the interrogation space by the first label if the first label is present in the interrogation space. The controller is configured to identify the presence of the target analyte in the sample based on electromagnetic radiation detected by the first detector.

A handheld solids dispenser. The dispenser includes a housing defining an inlet passage and an outlet passage. A delivery mechanism is supported within the housing and is positioned between the inlet passage and the outlet passage. Actuation of the delivery mechanism causes the delivery mechanism to transport a desired amount of solids material from the inlet passage to the outlet passage. The delivery member may be in the form of a plunger slidably positioned within the housing. The delivery mechanism may be in the form of a screw conveyor driven by a drive motor.

A liquid delivery device that includes a channel having an inner section lower than 9 mm.sup.2 and inner volume lower than 50 mL, a gas mass flowmeter connected to the inlet of the channel, and a pressure control unit suitable to control pressure inside the channel by flowing gas through the gas flowmeter.

Dosing unit for dosing liquids, having a fluid unit for selectively providing an overpressure and a negative pressure on a working gas, which is accommodated in a fluid channel which is connected at a first end region to the fluid unit and which includes a second end region, having a first valve unit and having a second valve unit, which are arranged spaced apart from one another along the fluid channel and are each designed for selectively blocking or releasing the fluid channel in order to form in the fluid channel a fluid reservoir which is delimited by the two valve units and is provided for storing working gas, having a control unit for controlling the valve units, the fluid reservoir being assigned a pressure sensor which is designed to provide a pressure signal as a function of a working gas pressure and is electrically connected to the control unit.

A method for filling a target volume into a container by means of a measuring arrangement is described and illustrated. The measuring arrangement includes at least one flowmeter for measuring the flow of a medium flowing into the container, at least one actuator and at least one control unit. The flowmeter includes a computing unit. The filling process can be started and ended by actuating the actuator. The control unit is connected to the actuator and the flowmeter via a communication system. The control unit is set up in such a way that, during operation, it sends a control command to the actuator to end the filling process when a defined limit value of the fill volume, which correlates with the target volume, is reached.

A peptide synthesis instrument can be used for small scale peptide synthesis. The instrument can include several unique features, including a compression style reaction vessel permitting quick setup of the reaction vessel, a double reaction vessel system permitting efficient mixing without loss of solvent or solvent-to-resin contact, gravity-fed heated reservoirs establishing a fixed volume for delivery to the reaction vessel, fume-free solvent addition permitting solvent addition to fixed bottles, and an improved amino acid manifold assembly which reduces the number of components and increases the ease of use of the instrument. Each of these features improve upon the current state of the art in solid phase automated peptide synthesizers.