A method for calorimetry includes providing a sample to a test chamber and applying heat to the test chamber with the sample provided therein, the heat being applied at a known heat rate. In a synchronized manner with respect to applying heat to the test chamber, transmission of light through plural Nano Hole Array (NHA) sensors coupled to the test chamber is measured to obtain a series of extraordinary optical transmission (EOT) measurements. A calorimetry measurement is calculated as a function of the heat rate and the series of EOT measurements, the calorimetry measurement being indicative of energy released as a result of the sample undergoing a change during the application of heat to the test chamber. Samples, including fluids and solids, can be transferred into the test chamber by a pump or other suitable means. Example test chambers include a microchannel injection cell and a co-flow reactor microchannel.

The present disclosure provides devices and methods for diagnosing, monitoring the disease progression of, and/or evaluating the risk for developing a disease by detecting thermostable variants of proteins and/or metabolites in biological samples using differential scanning calorimetry. Also disclosed herein are methods for monitoring the efficacy of a particular therapeutic regimen in patients in need thereof.

A method determining a degree of similarity between a first sample and a second sample, comprising using a processor to compare a first thermogram and a second thermogram, each obtained by performing scanning calorimetry on a first and second sample respectively, by: determining a smoothed first thermogram and a smoothed second thermogram by respectively performing a smoothing operation on the first thermogram and the second thermogram; determining a processed first thermogram and a processed second thermogram by respectively finding a derivative of the smoothed first thermogram and the smoothed second thermogram; determining the degree of similarity from a correlation operation comparing the processed first thermogram with the processed second thermogram.

A method for measuring thermal diffusivity/conductivity of a microscale sample includes placing a metallic disk atop the sample, and disposing a nanomembrane over the sample and over the metallic disk so that the nanomembrane, so that the metallic disk, the nanomembrane and the sample are in thermal equilibrium with one another. A laser beam is directed to fall onto the nanomembrane over the sample, while a radiation sensor is operated to detect photoluminescent radiation emitted by the nanomembrane in response to the laser beam. A spectral shift in the detected photoluminescent radiation emitted by the nanomembrane is determined, and thermal diffusivity/conductivity is calculated from the determined spectral shift of the photoluminescence.

An adiabatic coaxial cable connector includes a chassis, and a planar transmission line within the chassis and having first and second ends. The coaxial cable connector further includes a first coaxial-to-planar transition within the chassis and connected to the first end of the planar transmission line, and a second coaxial-to-planar transition within the chassis and connected to the second end of the planar transmission line.

A method for microscale calorimeter chamber data manipulation and visualization includes receiving a dataset from a microscale calorimeter chamber. The dataset is indicative of heat release rates for a test material as a function of a temperature applied by the microscale calorimeter chamber to the test material. The method further includes generating a baseline for correcting the heat release rates for the test material based on a selected temperature interval of the dataset. The method also includes generating a modified dataset that includes modified heat release rate values for the test material based on the baseline. The method includes generating a graphical user interface and displaying, via the graphical user interface, a graphical depiction of the modified dataset.

Various methods for sensing and/or heating that utilize nanostructures or carbon structures, such as nanotubes, nanotube meshes, or graphene sheets, are disclosed. In some methods, at least a pair of contacts are electrically coupled with a given nanostructure or carbon structure to sense a change or to pass a current for heating.

A nanocalorimeter device includes a substrate having test cells, each test cell comprising a sample location. Each sample location includes a reaction surface suitable for an enthalpic reaction of constituents of liquid droplets, droplet movement and configured to merge the droplets, and a layer of thermochromic material thermally coupled to the reaction surface. The thermochromic material is configured to exhibit a spectral shift in light emanating from the thermochromic material in response to a change in temperature of the merged droplets.

A method for calorimetry includes flowing a first fluid through a co-flow reactor microchannel having plural inlets and an outlet, the first fluid flowing through each of the inlets, and measuring transmission of light through a Nano Hole Array (NHA) sensor to obtain a baseline extraordinary optical transmission (EOT) measurement. The flow of the first fluid is stopped, the microchannel is emptied of the first fluid, and the first fluid and a second fluid are passed through the microchannel such that a reaction occurs, the first fluid flowing through a first of the inlets and the second fluid flowing through a second of the inlets. While flowing the first and second fluids, transmission of light through the NHA sensor is measured to obtain a reaction EOT measurement. A calorimetry measurement, indicative of energy released during the reaction, is calculated as a function of the baseline and reaction EOT measurements.

A method determining a degree of similarity between a first sample and a second sample, comprising using a processor to compare a first thermogram and a second thermogram, each obtained by performing scanning calorimetry on a first and second sample respectively, by: determining a smoothed first thermogram and a smoothed second thermogram by respectively performing a smoothing operation on the first thermogram and the second thermogram; determining a processed first thermogram and a processed second thermogram by respectively finding a derivative of the smoothed first thermogram and the smoothed second thermogram; determining the degree of similarity from a correlation operation comparing the processed first thermogram with the processed second thermogram.