A measurement system according to an aspect of the present invention enables measurement of an intensity distribution of diffracted X-rays obtained by irradiating a fillet portion of a metallic structure with X-rays, the metallic structure comprising: an axis portion; and a flange portion protruding radially from the axis portion, wherein the metallic structure comprises the fillet portion in a connection portion between the axis portion and the flange portion, the measurement system including: a diffracted X-rays measurement device provided with an irradiation unit that irradiates the fillet portion with X-rays; and a positioning device that positions the diffracted X-rays measurement device with respect to the fillet portion, in which the positioning device including: a moving mechanism that moves three-dimensionally the diffracted X-rays measurement device relative to the fillet portion; and a rotation mechanism that rotates the diffracted X-rays measurement device in such a direction that an angle of incidence of the X-rays with respect to the fillet portion is changed.

In an embodiment, an optical ice detection method is provided. The method includes contacting a multilayer structure with water under conditions effective to form ice, the multilayer structure comprising an optically transparent or semi-transparent material disposed over at least a portion of a material probe. The method further includes performing Raman spectroscopy on one or more of the material probe, water, or ice to obtain Raman spectra, detecting a shift in the Raman spectra, and calculating ice-induced strain in the material probe. Apparatus for optically detecting ice are also provided.

The invention relates to benzimidazoles of Formula (1)

##STR00001##

and pharmaceutically acceptable salts thereof, wherein R.sup.1 to R.sup.6 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes.

The benzimidazoles of Formula (1) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.

The invention relates to benzimidazoles of Formula (1)

##STR00001##

and pharmaceutically acceptable salts thereof, wherein R.sup.1 to R.sup.6 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes.

The benzimidazoles of Formula (1) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.

A deterioration evaluation method includes a determination step of determining a shot peening condition for imparting a maximum residual stress to an object formed of a metal material; a first shot peening step of performing first shot peening on the object under the shot peening condition; a first measurement step of measuring a first residual stress of the object after the first shot peening step; a second shot peening step of performing second shot peening on the object after the first measurement step under the shot peening condition; a second measurement step of measuring a second residual stress of the object after the second shot peening step; and an evaluation step of evaluating deterioration of the object based on the first residual stress and the second residual stress.

A deterioration evaluation method includes a determination step of determining a shot peening condition for imparting a maximum residual stress to an object formed of a metal material; a first shot peening step of performing first shot peening on the object under the shot peening condition; a first measurement step of measuring a first residual stress of the object after the first shot peening step; a second shot peening step of performing second shot peening on the object after the first measurement step under the shot peening condition; a second measurement step of measuring a second residual stress of the object after the second shot peening step; and an evaluation step of evaluating deterioration of the object based on the first residual stress and the second residual stress.

A method for measuring a residual stress of a curved-surface bulk material includes steps of: locating a point at which a to-be-detected curved surface of a curved-surface bulk material has a highest curvature as a to-be-detected point; applying an instrument integrating an X-ray light resource and a detector, measuring the to-be-detected point by using an X-ray diffraction theory, and analyzing and calculating, in combination with a cos α method, a strain value measured by using the instrument; and calculating, in combination with material property measurement data of the curved-surface bulk material, a curved-surface residual stress by introducing a curved-surface bulk material residual stress calculation model.

A method for measuring a residual stress of a curved-surface bulk material includes steps of: locating a point at which a to-be-detected curved surface of a curved-surface bulk material has a highest curvature as a to-be-detected point; applying an instrument integrating an X-ray light resource and a detector, measuring the to-be-detected point by using an X-ray diffraction theory, and analyzing and calculating, in combination with a cos α method, a strain value measured by using the instrument; and calculating, in combination with material property measurement data of the curved-surface bulk material, a curved-surface residual stress by introducing a curved-surface bulk material residual stress calculation model.

A friction force sensing system comprising one interrupter with a blocking extension and one flexible assembly having a fixed end and a free end, longitudinal flexures extending between said fixed end and said free end, said interrupter and said flexible assembly being fixedly connected to each other by a mounting element at the free end of said flexible assembly.

Systems and methods for rapid measurement of the chemical and structural properties of plastic articles are provided. The systems and methods involve measuring both mechanical deformation of the plastic article and x-ray fluorescence of the plastic article in order to determine changes in composition as a result of contamination and/or issues associated with plastic article manufacturing lines. The systems and methods can be performed in minutes, compared to hours or days for typical testing methods.