A method for evaluating Dry Eye Disease (“DED”) in a human or animal subject is provided. Thread thinning dynamics of a tear sample of the subject are determined using an acoustically-driven microfluidic extensional rheometry instrument. At least one physical parameter value of the tear sample is calculated based at least in part on the determined thread thinning dynamics. DED is evaluated based at least in part on the at least one calculated physical parameter value of the tear sample. A device for evaluating Dry Eye Disease (DED) in a human or animal subject is also provided. The device includes an acoustically-driven microfluidic extensional rheometry instrument and a processing device configured to evaluate DED based at least in part on the calculated at least one physical parameter value of the tear sample.

A method for evaluating Dry Eye Disease (“DED”) in a human or animal subject is provided. Thread thinning dynamics of a tear sample of the subject are determined using an acoustically-driven microfluidic extensional rheometry instrument. At least one physical parameter value of the tear sample is calculated based at least in part on the determined thread thinning dynamics. DED is evaluated based at least in part on the at least one calculated physical parameter value of the tear sample. A device for evaluating Dry Eye Disease (DED) in a human or animal subject is also provided. The device includes an acoustically-driven microfluidic extensional rheometry instrument and a processing device configured to evaluate DED based at least in part on the calculated at least one physical parameter value of the tear sample.

A viral inactivation device including at least one experimental continuous viral inactivation reactor having at least an inlet, an outlet, and a tubular flow path and a computer system that, based on the experimental continuous viral inactivation reactor can design, select, make, and/or manufacture a scaled actual reactor. The tubular flow path includes a set of alternating turns that form a serpentine or an interwoven pattern between the inlet and the outlet.

A method for verifying a density and/or viscosity measuring device in a measuring station of a process installation during ongoing operation, in which a medium flows through a main channel of the process installation, comprising steps: providing a side channel, which is connected as a bypass of the main channel, wherein the side channel is fluidically connected to the main channel via two regions of the main channel with mutually differing diameters; providing a MEMS-based master or control density measuring device in the side channel such that the MEMS-based master or control density measuring device is flowed through by the medium; performing at least one verification measurement with the MEMS-based master or control density measuring device; and verifying the density and/or viscosity measuring device based on the at least one verification measurement performed by the MEMS-based master or control density measuring device.

A method for verifying a density and/or viscosity measuring device in a measuring station of a process installation during ongoing operation, in which a medium flows through a main channel of the process installation, comprising steps: providing a side channel, which is connected as a bypass of the main channel, wherein the side channel is fluidically connected to the main channel via two regions of the main channel with mutually differing diameters; providing a MEMS-based master or control density measuring device in the side channel such that the MEMS-based master or control density measuring device is flowed through by the medium; performing at least one verification measurement with the MEMS-based master or control density measuring device; and verifying the density and/or viscosity measuring device based on the at least one verification measurement performed by the MEMS-based master or control density measuring device.

Systems and methods of the present disclosure relate to optimizing a tripping velocity profile for pipes in a wellbore. A method for optimizing a tripping velocity profile for a pipe, comprising: determining a static gel strength of a fluid of a wellbore; determining an acceleration curve for the pipe in the wellbore based on wellbore pressure constraints, wherein the wellbore pressure constraints are based in part on the static gel strength of the fluid; determining a deceleration curve for the pipe; and combining the acceleration curve with the deceleration curve to provide the tripping velocity profile for the pipe.

Systems and methods of the present disclosure relate to optimizing a tripping velocity profile for pipes in a wellbore. A method for optimizing a tripping velocity profile for a pipe, comprising: determining a static gel strength of a fluid of a wellbore; determining an acceleration curve for the pipe in the wellbore based on wellbore pressure constraints, wherein the wellbore pressure constraints are based in part on the static gel strength of the fluid; determining a deceleration curve for the pipe; and combining the acceleration curve with the deceleration curve to provide the tripping velocity profile for the pipe.

A method for evaluating signals of a sensor unit including at least two sensors. The method includes reading in a first sensor value of a first of the sensors and a second sensor value of a second sensor, the first and second sensor value each representing one parameter of a substance to be measured by the sensors or a linking of the parameters. A threshold value range is read in, which maps a range of combinations of at least the first and second sensor values, which represents the presence or a value of the substance to be measured in surroundings of the first and second sensors. A combination of the read-in first and second sensor values is recognized as being outside the threshold value range. The threshold value range is changed into a changed threshold value range so that the combination is situated within the changed threshold value range.

A method for evaluating signals of a sensor unit including at least two sensors. The method includes reading in a first sensor value of a first of the sensors and a second sensor value of a second sensor, the first and second sensor value each representing one parameter of a substance to be measured by the sensors or a linking of the parameters. A threshold value range is read in, which maps a range of combinations of at least the first and second sensor values, which represents the presence or a value of the substance to be measured in surroundings of the first and second sensors. A combination of the read-in first and second sensor values is recognized as being outside the threshold value range. The threshold value range is changed into a changed threshold value range so that the combination is situated within the changed threshold value range.

Provided are epithelial cell spheroids including spheroids that have apical membranes and cilia that face towards the interior core of the spheroid and spheroids that have apical membranes and cilia that face away from the interior core of the spheroid. Also provided methods of making and using such spheroids.