Device for detecting reactive luminescent particles embedded in a substrate or surface having an infrared or ultraviolet illuminator; a near-infrared photodiode sensor; a dark chamber, inside which the illuminator and photodiode sensor are mounted; a logarithm amplifier; an electronic data processor configured to detect the reactive luminescent particles by carrying out the steps of: illuminating the substrate or surface with the illuminator; acquiring the amplified linearized signal captured by the photodiode sensor; detecting the presence of luminescent particles in the substrate or surface from the linearized decay of the acquired signal. A further near-infrared photodiode sensor, a further logarithm amplifier, and a differentiator for obtaining a difference between amplified signals received by each photodiode sensor can be utilized.

A manifold system and methods of collecting samples, where the manifold system comprises multiple input sample ports and a preferably rotatable flow focusing element. The manifold system is able to sample aerosols and gases from multiple sample points, such as from cleanrooms and manufacturing environments, for collection and analysis. The flow focusing element reduces cross talk and cross contamination of particles, including nanoparticles, between different samples.

The present invention relates to the field of microfluidics and in particular to devices and methods for sorting objects in microfluidic channels. These devices and methods allow for fast and robust sorting in two-way and multi-way setups. They also enable sorting over extended periods of time.

The objective of the present invention is to provide a particle detection device and a particle detection method that can individually and continuously detect a wide range of particles. The objective is achieved by a particle detection device including: a particle separation channel through which particles are separated according to particle sizes in a perpendicular direction to the flow of fluid; and two or more particle recovery channels that are connected to and branched from the particle separation channel, in which each of the particle recovery channels includes a particle detection unit that includes an aperture and an electric detector.

The present disclosure relates to a bioparticle measuring method including forming on a solid phase a complex of a sample containing a bioparticle sampled from a specimen, a capturer containing a tag which binds to the solid phase and capable of binding to the bioparticle, and a detector capable of binding to the bioparticle and containing a labeled substance. A part or the whole of the complex may be dissociated from the solid phase to prepare a measurement sample containing a part or the whole of the complex not fixed on the solid phase, and signals from the measurement sample may be detected by a particle analyzer.

According to the present invention there is provided a first particle sensor, a second particle sensor and a device for characterisation of one or more particles in a fluid sample comprising a first particle sensor and/or at least one second particle sensor. A method for characterising one or more particles in a fluid sample is also disclosed.

A method for optically detecting biomarkers in a biosensor is disclosed, wherein the optical detection obtains spatially and spectrally resolved optical signals from a sample on a biosensor, and one or more of these spatially and spectrally resolved optical signals can be analyzed in parallel with image acquisition. The image analysis comprises reading data of the acquired images, correcting them to reduce inhomogeneities and noise, localizing particles in the images, characterizing each particle individually to obtain its position and characterization parameters, and classifying the particles based on their characterization parameters. Using the number of particles per class for all the acquired images of the sample, a statistical value is calculated per sample and each statistical value is correlated with an indication of the presence of a biomarker in the sample.

The disclosed subject matter compensates or corrects for errors that otherwise would be present when a measurement is made on a condensation particle counting system with the only difference causing the errors being absolute pressure. The difference in absolute pressure may be due to, for example, a change in altitude in which the condensation particle counting system is located. Techniques and mechanisms are disclosed to compensate for changes in particle count, at a given particle diameter, for changes in sampled absolute pressure at which measurements are taken. Other methods and apparatuses are disclosed.

The present disclosure relates generally to the field of analyzing a nucleic acid, such as RNA, in particular to the determination of at least one parameter of a sample composition comprising a nucleic acid, especially RNA, and optionally particles.

The present invention relates to a method for measuring characteristics of particles in solution and to a device for performing the same, wherein said method comprises the steps of providing a vessel comprising a sample of said particles in solution, wherein the sample has preferably a volume between 0.1 μL and 15 μL, providing a monochromatic light source and a light detector, transmitting light from the monochromatic light source to the vessel comprising the sample, detecting light emitted from the vessel with the light detector, and determining characteristics of said particles in solution comprised in the sample based on a dynamic light scattering (DLS) measurement.