A particulate matter sensor device comprising an enclosure (21) that comprises a flow inlet (11), a flow outlet (12) and a flow channel (2) extending therebetween, a radiation source for emitting radiation into the flow channel (2) for interaction of the radiation with the particulate matter in the flow (20) of an aerosol sample when guided through the flow channel (2), a radiation detector (4) for detecting at least part of said radiation after interaction with the particulate matter. The sensor device comprises a flow modifying device (511) arranged upstream of the radiation detector (4) and/or of the radiation source (3) for modifying the flow (20) for reducing particulate matter precipitation onto the radiation detector (4) and/or onto the radiation source (3) and/or the channel wall sections in close proximity to the detector (4) and/or source (3). The invention also relates to a method of determining parameters of particulate matter in an aerosol sample by using such a particulate matter sensor device.

A photonic aerosol particle sensor includes a microfluidic sensor chamber in which is disposed a plurality of photonic waveguide resonators each having a photonic waveguide on an underlying substrate, along a separate waveguide resonator path with a lateral width different than that of other photonic waveguide resonators. All waveguides in the plurality have a common vertical thickness of a common waveguide material having a refractive index that is larger than that of the underlying substrate material. An optical input connection couples light into the waveguide resonators. An aerosol particle input fluidically connected to the microfluidic chamber fluidically conveys aerosol particles to the chamber, and an aerosol particle output fluidically connected to the microfluidic chamber fluidically conveys aerosol particles out of the chamber. At least one optical output connection accepts light out of the plurality of photonic waveguide resonators to provide a signal indicative of at least one aerosol particle characteristic.

Methods for determining a radius of gyration of a particle in solution using a light scattering detector are provided. The method may include passing the solution through a flowpath in a sample cell, determining respective angular normalization factors for first and second angles of the detector, obtaining a first scattering intensity of the particle in solution at the first angle, obtaining a second scattering intensity of the particle in solution at the second angle, obtaining a 10° scattering intensity of the particle in solution at an angle of about 10°, determining a first particle scattering factor, determining a second particle scattering factor, plotting an angular dissymmetry plot, fitting a line to the angular dissymmetry plot, determining a slope of the line at a selected location on the line, determining the radius of gyration of the particle in solution from the slope of the line, and outputting the radius of gyration.

The invention relates to a liquid cell (1) for the microscopic image capture and Raman spectroscopic material analysis of a particle suspension in a reflected light microscope, having at least the following components: a measuring chamber (2) which has a base (3), a measuring window (5) opposite the base (3), and a seal (6), wherein the base (3) has a planar design at least in one region of the support of the seal (6), and the base (3) has a reflective surface (4) which is provided such that Raman excitation light incident through the measuring window (5) is reflected on the reflective surface (4) in a directed manner such that the background signal in a Raman measurement is reduced and the Raman signal of a particle in a suspension is increased. The invention further relates to a microscope which has such a liquid cell.

Methods for determining a radius of gyration of a particle in solution using a light scattering detector are provided. The method may include passing the solution through a flowpath in a sample cell, determining respective angular normalization factors for first and second angles of the detector, obtaining a first scattering intensity of the particle in solution at the first angle, obtaining a second scattering intensity of the particle in solution at the second angle, obtaining a 10° scattering intensity of the particle in solution at an angle of about 10°, determining a first particle scattering factor, determining a second particle scattering factor, plotting an angular dissymmetry plot, fitting a line to the angular dissymmetry plot, determining a slope of the line at a selected location on the line, determining the radius of gyration of the particle in solution from the slope of the line, and outputting the radius of gyration.

A device for characterizing substances in a scene, the device including a housing having a cavity configured to contain the substances, an opening for receiving the substances, an imager for capturing an image of the substances, an illumination source for illuminating the substances, a sensor for obtaining sensory data of the substances, a gas supply device for storing and inserting gas into the housing, a mechanical arm for inserting or removing the substances into or from the device via the opening, a syringe to add a material into the housing, a pump for creating a vacuum in the device, an air pump to suck air from the housing and removing the substances from the housing, a fan for cooling the housing, a fluid injector for inserting fluid into the housing, and a processor in communication with the imager and the sensor imaging module. The processor receives the sensory data and the captured images, and compares them to a. database to identify the characteristics of the substances.

An apparatus and method for bio-particle detection are provided. The apparatus for bio-particle detection includes: a bio-particle detection chip including a substrate having a plurality of through-hole groups, each through-hole group of the plurality of through-hole groups including through-holes which pass through the substrate from a first surface of the substrate toward an second surface of the substrate opposite to the first surface, and which are configured to accommodate a sample solution loaded therein; and a processor configured to determine a number of through-holes, among the through holes of at least one through-hole group of the plurality of through-hole groups, having a target material encapsulated therein, based on at least one of an electrical signal and an optical signal corresponding to the through-holes of the at least one through-hole group, and to estimate a concentration of the target material based on the determined number.

A laser sensor for detecting a particle density includes: a laser configured to emit a measurement beam, an optical arrangement being arranged to focus the measurement beam to a measurement volume, the optical arrangement having a numerical aperture with respect to the measurement beam, a detector configured to determine a self-mixing interference signal of a optical wave within a laser cavity of the laser, and an evaluator. The evaluator is configured to: receive detection signals generated by the detector in reaction to the determined self-mixing interference signal, determine an average transition time of particles passing the measurement volume in a predetermined time period based on a duration of the self-mixing interference signals generated by the particles, determine a number of particles based on the self-mixing interference signals in the predetermined time period, and determine the particle density based on the average transition time and the number of particles.

Systems and methods for uniquely identifying fluid-phase products by endowing them with fingerprints composed of dispersed colloidal particles, and by reading out those fingerprints on demand using Total Holographic Characterization. A library of chemically inert colloidal particles is developed that can be dispersed into soft materials, the stoichiometry of the mixture encoding user-specified information, including information about the host material. Encoded information then can be recovered by high-speed analysis of holographic microscopy images of the dispersed particles. Specifically, holograms of individual colloidal spheres are analyzed with predictions of the theory of light scattering to measure each sphere's radius and refractive index, thereby building up the distribution of particle properties one particle at a time. A complete analysis of a colloidal fingerprint requires several thousand single-particle holograms and can be completed in ten minutes.

The present disclosure provides apparatuses, systems, and methods for performing particle analysis through flow cytometry at comparatively high event rates and for gathering high resolution images of particles.