A scatterer measurement method includes: radiating a first irradiating light that passes through a first space in which a scatterer is present; receiving a first scattered light produced by the first irradiating light being scattered by the scatterer; after the scatterer has moved from the first space to a second space at least partially different from the first space, radiating a second irradiating light that passes through the second space; receiving a second scattered light produced by the second irradiating light being scattered by the scatterer; and calculating a velocity of the scatterer based on a difference between a first point in time at which the first scattered light was received and a second point in time at which the second scattered light was received and a distance that the scatterer moved during a period from the first point in time to the second point in time.

The present claimed invention is to facilitate cleaning work of a cell for a particle size distribution measuring device that measures a particle size distribution by means of a line start method, and comprises a cell 2 that houses a density gradient solution, a cell rotating mechanism 3 that rotates the cell 2 so that a centrifugal force is applied to the cell 2 from a smaller density gradient to a larger density gradient and a sample introducing mechanism 7 that introduces a measurement sample into the cell 2 that is rotated by the cell rotating mechanism 3, and is so configured that the cell 2 is detachable from a main body of the device.

A method for diagnosing COVID-19 infection. The method includes drawing a blood sample from a person suspected to be infected with COVID-19 virus, separating a blood serum sample from the blood sample by centrifuging the blood sample, recording an electrochemical impedance spectroscopy (EIS) associated with the blood serum sample, calculating a charge transfer resistance (R.sub.CT) of the recorded EIS by measuring a diameter of a semicircular curved part of the recorded EIS, and detecting a COVID-19 infection of the person based on the calculated R.sub.CT if the calculated R.sub.CT is equal to or more than a threshold value.

The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

An in-situ measurement apparatus automatically draws aqueous samples on an intermittent or ad-hoc basis and measures specific metal specie concentration. The apparatus can perform both raw measurement of specific metal specie, as well as processing to convert other species of the same metal to the specific metal specie or to destroy or remove unwanted masking agents (e.g. organics). In one application, “dirty” water from a scrubber is measured for Se(IV) presence (using a renewable voltametric system), both with and without the masking agents present; in addition, selective processing converts other selenium species to Se(IV), permitting assessment of total selenium and measurement of Se(VI) presence. Automated reactions can then be taken to remove detected toxic substances from waste water without excess reliance on treatment chemicals, and so as to ensure that only water complaint with regulatory standards is released into the environment.

An in-situ measurement apparatus automatically draws aqueous samples on an intermittent or ad-hoc basis and measures specific metal specie concentration. The apparatus can perform both raw measurement of specific metal specie, as well as processing to convert other species of the same metal to the specific metal specie or to destroy or remove unwanted masking agents (e.g. organics). In one application, “dirty” water from a scrubber is measured for Se(IV) presence (using a renewable voltametric system), both with and without the masking agents present; in addition, selective processing converts other selenium species to Se(IV), permitting assessment of total selenium and measurement of Se(VI) presence. Automated reactions can then be taken to remove detected toxic substances from waste water without excess reliance on treatment chemicals, and so as to ensure that only water complaint with regulatory standards is released into the environment.

Described embodiments relate to a hand-held portable sedimentation measurement device, comprising: a closeable fluid container having a container wall and defining a chamber to receive fluid for sedimentation measurement and defining a central longitudinal axis; multiple light sources disposed along the container and generally parallel to the longitudinal axis to direct light through the wall into the chamber; multiple light sensors disposed along the container arranged to detect light passing through the chamber from at least one of the light sources; a controller configured to control emission of light from the sources and to receive detection signals from the light sensors, wherein sedimentation measurements are derived from the light emitted from the light sources and the detection signals; a communication interface coupled to the controller and arranged to transmit sedimentation data to an external computing device; and a housing connected to the container and housing the controller and interface.

Described embodiments relate to a hand-held portable sedimentation measurement device, comprising: a closeable fluid container having a container wall and defining a chamber to receive fluid for sedimentation measurement and defining a central longitudinal axis; multiple light sources disposed along the container and generally parallel to the longitudinal axis to direct light through the wall into the chamber; multiple light sensors disposed along the container arranged to detect light passing through the chamber from at least one of the light sources; a controller configured to control emission of light from the sources and to receive detection signals from the light sensors, wherein sedimentation measurements are derived from the light emitted from the light sources and the detection signals; a communication interface coupled to the controller and arranged to transmit sedimentation data to an external computing device; and a housing connected to the container and housing the controller and interface.

Apparatus, system and method for dispensing a particle-laden fluid from a fluid holding and dispensing micro-feature and/or multiple lysing channel structures. In some implementations, the apparatus includes: a chamber having one or more surfaces that define a volume to receive fluid containing particulate matter, a soluble surface coating on a portion of the one or more surfaces of the chamber, and an outlet port to dispense at least a portion of the fluid from the chamber. In some implementations, the particle-laden fluid may be whole blood, and the soluble surface coating may include reagents and/or dyes that are diffused into the whole blood received within the chamber to generate signals to visualize various cellular components. In some implementations, the apparatus may also include a second soluble surface coating on portions of surfaces of the multiple lysing channel structures.

An automated isolation device for isolation of mitochondria includes an incubation station including a holder for a viable mitochondria solution; and a cooling system, controlled by a processor of the device, for cooling the holder. The device includes a processor-controlled transfer system for transferring solution from the holder to a filtration station; and the filtration station, including a series of filters. The device includes a processor-controlled spectrometry station including a spectrometer positioned to illuminate a cuvette fluidically coupled to an output of the filtration station; and a detector coupled to the processor and positioned on a side of the cuvette opposite the spectrometer. The device includes a processor-controlled transfer system for transferring solution from the spectrometry station to a centrifuge. The centrifuge is processor-controlled and configured to centrifuge the filtrate to separate viable mitochondria from a supernatant.