A fiber optic sensor for measuring voltage in direct current and alternating current systems is disclosed. The sensor may include an optical fiber probe containing transmitting and receiving fibers, fixed conductor elements, and a dynamic conductor element with a reflective surface or material. The reflector may be attached to a dynamic conductor. The two fixed conductors may be placed parallel to one another and coupled to a static voltage source. The dynamic conductor may bisect the fixed conductors and be coupled to a voltage source. The dynamic conductor may be spaced apart from the ends of the fibers in the fiber probe, and positioned so that light transmitted through the transmitting fiber is reflected by that surface into a receiving fiber. A light sensing means may be coupled to the receiving fiber, so light from a light reflected by the reflector body back into the receiving fibers is detected.

Disclosed herein are methods of preparing a composition comprising crystalline biomolecules, for example, crystalline antibodies. In exemplary embodiments, the method comprises forming a fluidized bed of crystalline biomolecules using, for example, a counter-flow centrifuge to exchange buffer and/or to concentrate the crystalline biomolecules in a solution. Also provided are methods of detecting crystalline biomolecules and/or amorphous biomolecules in a sample.

An exhaust gas sensing system includes a channel for flow of exhaust gas, a first directional antenna, a second directional antenna, a first transmitter, a first receiver, and signal processing circuitry. The first directional antenna and the second directional antenna are disposed in the channel. The first transmitter is coupled to the first directional antenna. The first receiver is coupled to the second directional antenna. The signal processing circuitry is coupled to the first transmitter and the first receiver.

Determining a modal amplitude of an inhomogeneous field includes: preparing an initial entangled state of a quantum sensor; subjecting the quantum sensor to the inhomogeneous field of the analyte; subjecting a first qudit sensor of the quantum sensor to a first perturbation pulse; receiving the first perturbation pulse by the first qudit sensor to prepare a first intermediate entangled state of the quantum sensor, the first intermediate entangled state comprising a first intermediate linear superposition; changing the initial linear superposition to the first intermediate linear superposition in response to receiving the first perturbation pulse by the quantum sensor; and determining a final entangled state of the quantum sensor after applying the first perturbation pulse to determine the modal amplitude of the inhomogeneous field of the analyte.

A fiber optic sensor for measuring voltage in direct current and alternating current systems is disclosed. The sensor may include an optical fiber probe containing transmitting and receiving fibers, fixed conductor elements, and a dynamic conductor element with a reflective surface or material. The reflector may be attached to a dynamic conductor. The two fixed conductors may be placed parallel to one another and coupled to a static voltage source. The dynamic conductor may bisect the fixed conductors and be coupled to a voltage source. The dynamic conductor may be spaced apart from the ends of the fibers in the fiber probe, and positioned so that light transmitted through the transmitting fiber is reflected by that surface into a receiving fiber. A light sensing means may be coupled to the receiving fiber, so light from a light reflected by the reflector body back into the receiving fibers is detected.

Nuclear Magnetic Resonant Imaging (also called Magnetic Resonant Imaging or MRI) devices which are implantable, internal or insertable are provided. The disclosure describes ways to miniaturize, simplify, calibrate, cool, and increase the utility of MRI systems for structural investigative purposes, and for biological investigation and potential treatment. It teaches use of target objects of fixed size, shape and position for calibration and comparison to obtain accurate images. It further teaches cooling of objects under test by electrically conductive leads or electrically isolated leads; varying the magnetic field of the probe to move chemicals or ferrous metallic objects within the subject. The invention also teaches comparison of objects using review of the frequency components of a received signal rather than by a pictorial representation.

Disclosed herein are methods of preparing a composition comprising crystalline biomolecules, for example, crystalline antibodies. In exemplary embodiments, the method comprises forming a fluidized bed of crystalline biomolecules using, for example, a counter-flow centrifuge to exchange buffer and/or to concentrate the crystalline biomolecules in a solution. Also provided are methods of detecting crystalline biomolecules and/or amorphous biomolecules in a sample.

Molecular rotational resonance (MRR) spectroscopy is a structurally-specific, high-resolution spectroscopy technique that can provide accurate reaction process data with finer time resolution than existing techniques. It is the only analytical technique that can make online chiral composition measurements. This makes it especially useful for online reaction monitoring, which is done today by manually pulling off samples and measuring samples offline and takes 3-4 hours per measurement. Conversely, an MRR spectrometer can resolve isomers in about 10 minutes when fed with a low-volatility sampling interface that connects directly to the reaction line. The sampling interface measures a precise sample of the reaction solution, boils off the solvent to concentrate the analyte, volatilizes the analyte, and injects the volatilized analyte into the MRR spectrometer's measurement chamber for an MRR measurement. The sample concentration and volatilization happen quickly and without any extra sample preparation.

Molecular rotational resonance (MRR) spectroscopy is a structurally-specific, high-resolution spectroscopy technique that can provide accurate reaction process data with finer time resolution than existing techniques. It is the only analytical technique that can make online chiral composition measurements. This makes it especially useful for online reaction monitoring, which is done today by manually pulling off samples and measuring samples offline and takes 3-4 hours per measurement. Conversely, an MRR spectrometer can resolve isomers in about 10 minutes when fed with a low-volatility sampling interface that connects directly to the reaction line. The sampling interface measures a precise sample of the reaction solution, boils off the solvent to concentrate the analyte, volatilizes the analyte, and injects the volatilized analyte into the MRR spectrometer's measurement chamber for an MRR measurement. The sample concentration and volatilization happen quickly and without any extra sample preparation. This makes reaction monitoring more feasible, contributing to the manufacturing of safer, cheaper, and more effective drugs.