Disclosed herein is a method of conducting direct detection .sup.1H solid state NMR (“ssNMR”) on a macromolecule-containing solid state formulation. The method includes conducting a .sup.1H spin-lattice relaxation time (“T.sub.1”) experiment on the solid state formulation at various temperatures to generate a T.sub.1 value at each temperature, converting the T.sub.1 values to .sup.1H spin-lattice relaxation rate (“R.sub.1”), and plotting R.sub.1 versus temperature to generate a relaxation rate curve for the solid state formulation. The relaxation rate curve can be analyzed to determine the molecular mobility of the macromolecule in the solid state formulation, the degree of aggregation in the solid state formulation, and/or the stability of the solid state formulation.

Superparamagnetic nanoparticle-based analytical method comprising providing a sample having analytes in a sample matrix, providing a point of care chip having analytical regions, each of which is a stationary phase having at least one or more sections, labeling each of the analytes with a superparamagnetic nanoparticle and immobilizing the labeled analytes in the stationary phase, providing an analytical device having a means for exciting the superparamagnetic nanoparticles in vitro and a means for sensing, receiving, and transmitting response of the excited superparamagnetic nanoparticles, placing the chip in the analytical device and exciting the superparamagnetic nanoparticles in vitro, sensing, receiving, and transmitting the response of the superparamagnetic nanoparticles, and analyzing the response and determining characteristic of the analytes, wherein the response of the superparamagnetic nanoparticles comprises harmonics. The present invention also provides the hybrid point of care chip and analyzer to be used in the analytical method.

A method of using the transverse relaxation rate (R.sub.2) of solvent NMR signal to noninvasively assess alum-containing products such as vaccines. This technique can be used for quality control in vaccine manufacturing (e.g., fill-finish step) to determine the evenness of alum filling level as well as extent of alum particle sedimentation in filled and sealed products.

An automated or robotic mud-logger having a slurry sampler to collect a slurry sample online from a drilling fluid circuit contemporaneous with drilling of a borehole, the slurry sample including drilling fluid and rock cuttings. A liquid separator removes drilling fluid from the slurry sample and discharges a sample of the rock cuttings. A spectrometer performs elemental analysis of the sample of the rock cuttings substantially in real time with collection of the slurry sample.

The present disclosure relates to a method and system for predicting a disturbance response to an injection of carbon dioxide into a multi-scale rock mass. The method includes: predicting a disturbance response to an injection of supercritical carbon dioxide into a multi-scale rock matrix; predicting a disturbance response to an injection of supercritical carbon dioxide into a multi-scale rock mass structure; and predicting a disturbance response to an injection of supercritical carbon dioxide into a multi-scale rock matrix-rock mass structure system. The method in the present disclosure can accurately analyze a cross-scale spatio-temporal evolution process of the multi-scale rock mass and seepage mechanics under disturbance of the injection of supercritical carbon dioxide.

The current invention is based, at least in part, on the finding that the transverse nuclear magnetic spin relaxation time T2 and the transverse nuclear magnetic spin relaxation rate R2, respectively, of protons of water molecules in an aqueous solution comprising viral particles depends on the loading status (full vs. empty) of the viral particle. Thus, one aspect of the current invention is a method for determining the ratio of loaded viral particles to empty viral particles in a sample, comprising the steps of determining a nuclear magnetic resonance (NMR) parameter related to the protons of the water molecules present in an aqueous solution comprising a mixture of loaded and empty viral particles by applying an NMR measurement to the solution, and determining the ratio of loaded viral particles to empty viral particles with the NMR parameter determined in the previous step based on a calibration function.

This invention provides, among other things, methods for determining the average number of first polymers covalently attached to protein-first polymer conjugates in a solution.

This invention provides, among other things, methods for determining the average number of first polymers covalently attached to protein-first polymer conjugates in a solution.

The present specification relates to a method for analyzing a deuterated compound by chromatography, and manufacturing an organic light emitting device using a deuterated compound selected based on the analyzed data.

The present specification relates to a method for analyzing a deuterated compound by chromatography, and manufacturing an organic light emitting device using a deuterated compound selected based on the analyzed data.