A method for generating a nuclear magnetic resonance spectrum of nuclear spin moments of a sample includes a static magnetic field permeating the sample, and a detection spin moment with a detection region surrounding the latter. The detection region extends at least partly into the sample. The method also includes an antenna element for radiating in frequency pulses for influencing the nuclear spin moments and radio-frequency pulses for influencing the detection spin moment, where a polarization step involves polarizing at least one portion of the nuclear spin moments along the magnetic field to form a longitudinal magnetization, where a transfer step involves converting the longitudinal magnetization (M.sub.x) into a transverse magnetization (M.sub.xy) by radiating in a frequency pulse (F) with a 90° flip angle, wherein a detection step involves radiating in a sequence of radio-frequency pulses onto the detection spin moment and subsequently detecting a signal (32′) of the transverse magnetization (M.sub.xy) present in the detection region and storing the signal as detection result in a list. The detection step is carried out a number of times repeatedly in succession, wherein the polarization step and the transfer step and also the detection steps are carried out.

Systems and methods directed to a quantum processing apparatus are provided. The apparatus comprises M solid-state qubits, where M>1, and control electronics, which are connected to the solid-state qubits. The control electronics comprise one or more qubit readout circuits, where each of the qubit readout circuits is connected to at least one of the solid-state qubits and comprises a downsampling analog-to-digital converter (hereafter DSADC). Each DSADC is configured to downsample analog signals obtained from the at least one of the solid-state qubits. Such a DSADC operates in the n.sup.th Nyquist zone of the spectrum of the analog signals obtained, so as to down-convert such analog signals from the n.sup.th Nyquist zone to the m.sup.th Nyquist zone of the spectrum, where n>m≥1, prior to sampling the analog signals to convert them into digital signals, in operation. One or more embodiments of the invention are further directed to a related method of operating such a quantum processing apparatus.

Systems and methods directed to a quantum processing apparatus are provided. The apparatus comprises M solid-state qubits, where M>1, and control electronics, which are connected to the solid-state qubits. The control electronics comprise one or more qubit readout circuits, where each of the qubit readout circuits is connected to at least one of the solid-state qubits and comprises a downsampling analog-to-digital converter (hereafter DSADC). Each DSADC is configured to downsample analog signals obtained from the at least one of the solid-state qubits. Such a DSADC operates in the n.sup.th Nyquist zone of the spectrum of the analog signals obtained, so as to down-convert such analog signals from the n.sup.th Nyquist zone to the m.sup.th Nyquist zone of the spectrum, where n>m≥1, prior to sampling the analog signals to convert them into digital signals, in operation. One or more embodiments of the invention are further directed to a related method of operating such a quantum processing apparatus.

A method and a device for detecting substances and their concentrations in a mixture using magnetic resonance, containing one or more markers deposited on a surface of a carrier in contact with the mixture, wherein the marker is a substance that through intermolecular interactions causes a predetermined orientation of molecules for at least one of the mixture components.

Electrochemical devices with metal casings have been considered incompatible with nuclear magnetic resonance (NMR) spectroscopy because the oscillating magnetic fields (“rf fields”) responsible for excitation and detection of NMR active nuclei do not penetrate metals. According to the present invention, rf fields can still efficiently penetrate into nonmetallic layers of electrochemical cells (such as a coin cell battery configuration) provided the magnetic field is oriented tangentially to the electrochemical cell electrodes in a “skimming” orientation. As an example, noninvasive high field in situ .sup.7Li and .sup.19F NMR of an unmodified commercial off-the-shelf rechargeable coin cell was demonstrated using a traditional external NMR coil setup. The in operando NMR measurements revealed that irreversible physical changes accumulate at the anode during electrochemical cycling.

Electrochemical devices with metal casings have been considered incompatible with nuclear magnetic resonance (NMR) spectroscopy because the oscillating magnetic fields (“rf fields”) responsible for excitation and detection of NMR active nuclei do not penetrate metals. According to the present invention, rf fields can still efficiently penetrate into nonmetallic layers of electrochemical cells (such as a coin cell battery configuration) provided the magnetic field is oriented tangentially to the electrochemical cell electrodes in a “skimming” orientation. As an example, noninvasive high field in situ .sup.7Li and .sup.19F NMR of an unmodified commercial off-the-shelf rechargeable coin cell was demonstrated using a traditional external NMR coil setup. The in operando NMR measurements revealed that irreversible physical changes accumulate at the anode during electrochemical cycling.

Electrochemical devices with metal casings have been considered incompatible with nuclear magnetic resonance (NMR) spectroscopy because the oscillating magnetic fields (“rf fields”) responsible for excitation and detection of NMR active nuclei do not penetrate metals. According to the present invention, rf fields can still efficiently penetrate into nonmetallic layers of electrochemical cells (such as a coin cell battery configuration) provided the magnetic field is oriented tangentially to the electrochemical cell electrodes in a “skimming” orientation. As an example, noninvasive high field in situ .sup.7Li and .sup.19F NMR of an unmodified commercial off-the-shelf rechargeable coin cell was demonstrated using a traditional external NMR coil setup. The in operando NMR measurements revealed that irreversible physical changes accumulate at the anode during electrochemical cycling.

Electrochemical devices with metal casings have been considered incompatible with nuclear magnetic resonance (NMR) spectroscopy because the oscillating magnetic fields (“rf fields”) responsible for excitation and detection of NMR active nuclei do not penetrate metals. According to the present invention, rf fields can still efficiently penetrate into nonmetallic layers of electrochemical cells (such as a coin cell battery configuration) provided the magnetic field is oriented tangentially to the electrochemical cell electrodes in a “skimming” orientation. As an example, noninvasive high field in situ .sup.7Li and .sup.19F NMR of an unmodified commercial off-the-shelf rechargeable coin cell was demonstrated using a traditional external NMR coil setup. The in operando NMR measurements revealed that irreversible physical changes accumulate at the anode during electrochemical cycling.

The present application discloses a sensor system that includes a sensor having a sensor surface, a sample cartridge including one or more flexible membranes and a membrane frame, the membrane frame including one or more openings covered by the one or more flexible membranes defining one or more wells for holding one or more samples, the flexible membrane having a sample side supporting the sample and an opposite sensor side, the sample cartridge being removably insertable in the sensor system such that the sensor side of the flexible membrane is positioned above and faces the sensor surface, a displacement mechanism that can be actuated to displace the flexible membrane toward the sensor surface such that the sample is moved to a position closer to the sensor surface, and an optical imaging system that detects light emitted from the sensor. Disclosed also are a cartridge cassette and a method of use.

The invention relates to a method for the hyperpolarization of a material sample (4), which hits a number of first spin moments (10) of a first spin moment type, wherein the number of first spin moments (10) is brought into interaction with a second spin moment (16) of a second spin moment type, wherein the first spin moments (10) are nuclear spin moments and the second spin moment (16) is an election spin moment, wherein the first and second spin moments (10, 16) are exposed to a homogeneous magnetic field (B), wherein the second spin moment (16) is polarized along the magnetic field (B), wherein the second spin moment (16) is coherently manipulated by means of a, preferably repeated, sequence (S) having a number of successive high-frequency pulses (P.sub.ki, P.sub.k′i) temporally offset to each by durations (T.sub.ki, T.sub.k′i, T), in such a way that a polarization transfer from the second spin moment (16) to the first spin moments (10) occurs, and wherein durations (T.sub.ki, T.sub.k′i, T) inversely proportional to a Lamor frequency (ω.sub.Larmor) of the first spin moments (10) in the magnetic field (B) are inserted between high-frequency pulses (P.sub.ki, P.sub.k′i).