The present disclosure provides a wafer sample analysis method and device. The method is applied to a secondary-ion-mass spectroscope (Sims) and includes: providing a wafer sample, the wafer sample at least including a slope configured to expose a substrate, a first protective layer and a first doped layer on a same surface, the first protective layer being formed on the substrate, and the first doped layer being formed on the first protective layer; and acquiring and analyzing a slope image of the slope to obtain a doping depth and a doping concentration of elements in the wafer sample in the slope image.

A door 4 includes a closing portion 41 that closes an opening 302 in a closed state, and a holding portion 42 that holds the closing portion 41 and is connected to a hinge portion 5. The closing portion 41 is connected to the holding portion 42 on the side opposite to the hinge portion 5 side, and is configured to be separable from the holding portion 42 on the hinge portion 5 side. In a case where the door 4 is rotated from an open state to a closed state, the closing portion 41 is configured to be in contact with a peripheral edge portion of the opening 302 on the side opposite to the hinge portion 5 side before the closing portion 41 comes into contact with a peripheral edge portion of the opening 302 on the hinge portion 5 side.

Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.

A hydrogen flame ionization detector includes a nozzle configured to eject a sample gas upward, a cylindrical collector provided above the nozzle with a longitudinal direction thereof vertically oriented, the collector being configured to collect ions generated by a hydrogen flame formed at a tip of the nozzle, an insulator provided to hold the collector therein in such a manner as to extend in a radially inward direction of the collector, and a collector housing configured to accommodate the collector therein in such a manner as to surround an outer peripheral surface of the collector while holding a peripheral portion of the insulator. An accumulation suppression structure is provided above the insulator to suppress a material emitted from an upper end of the collector from being accumulated in such a manner as to shorten an insulation distance between the collector and the collector housing.

A non-transitory computer-readable medium, an information processing device, and an information processing method that causes a computer processor to execute a process that includes: outputting a first question by voice; receiving an answer to the first question from a subject; outputting a second question by text; receiving an answer to the second question from the subject; determining whether or not the answers to the first and second questions are correct; and estimating a possibility of a brain dysfunction of the subject based on correctness or incorrectness of the answers to the first and second questions.

Provided is an ion source achieving high sensitivity and high robustness while executing a plurality of types of ionization schemes. To this end, a hybrid ion source (1) includes: a chamber (24); a first ion source (2) to spray a sample solution (5) for ionization; a second ion source (3) to ionize droplets and/or a gas component sprayed from the first ion source (2); a first electrode (11) to introduce a first ion (7) generated by the first ion source (2), and a second ion generated by the second ion source (3); and an exhaust pump (27) that generates air flow (26) in a direction from a first space area (23) where the first ion (7) is generated to a second space area (19) in the second ion source (3) where the second ion is generated.

A method is described that produces product ions for mass analysis, the method comprising the steps of: introducing precursor ions into an RF electric field ion containment device, introducing reagent ions into the RF electric field ion containment device and performing an ion-ion interaction in the RF electric field ion containment device by co-trapping the precursor ions with the reagent ions. Precursor ions and product ions may be retained and/or isolated in the RF electric field ion containment device. The steps above may be repeated until a predetermined amount of reaction completeness is attained. Mass analysis of at least some of the ions in the RF electric field ion containment device may be performed where the ions are mass analyzed either directly from the RF electric field ion containment device.

An ion mobility spectrometry apparatus and method wherein ions are selected using an AC gate, then separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis.

The present disclosure provides a method for analyzing a microRNA using a tunneling current. The present disclosure provides a method for identifying the base sequence and/or modification state of a microRNA using a tunneling current, and a system and a program to be used in the method. Furthermore, the present disclosure provides a method for analyzing the conditions of a subject, said method comprising determining the base sequence and/or modification state of a microRNA using a tunneling current. For example, methylation modification can be analyzed thereby.

The present disclosure provides a method for analyzing a microRNA using a tunneling current. The present disclosure provides a method for identifying the base sequence and/or modification state of a microRNA using a tunneling current, and a system and a program to be used in the method. Furthermore, the present disclosure provides a method for analyzing the conditions of a subject, said method comprising determining the base sequence and/or modification state of a microRNA using a tunneling current. For example, methylation modification can be analyzed thereby.