Described are an apparatus, computer program product, and associated methods for shaped waveform acoustic interrogation of substances and materials to determine one or more properties of the materials or substances. In some embodiments, a shaped waveform is formed by summing two or more different waveforms and an acoustic wave is generated according to the shaped waveform. The acoustic wave is transmitted by one or more transmitting transducers through the substance or material and received by one or more receiving transducers. The shaped waveform acoustic wave can have a duration or a period that is less than about 20 μs and can comprise predetermined frequency content. Characteristics of the shaped waveform acoustic wave, as received at the receiving transducer(s), including characteristics such as amplitude, frequency, time of flight, etc., can be associated with said one or more properties of the substance or material to provide for real-time monitoring of these properties.

Described are an apparatus, computer program product, and associated methods for shaped waveform acoustic interrogation of substances and materials to determine one or more properties of the materials or substances. In some embodiments, a shaped waveform is formed by summing two or more different waveforms and an acoustic wave is generated according to the shaped waveform. The acoustic wave is transmitted by one or more transmitting transducers through the substance or material and received by one or more receiving transducers. The shaped waveform acoustic wave can have a duration or a period that is less than about 20 μs and can comprise predetermined frequency content. Characteristics of the shaped waveform acoustic wave, as received at the receiving transducer(s), including characteristics such as amplitude, frequency, time of flight, etc., can be associated with said one or more properties of the substance or material to provide for real-time monitoring of these properties.

A detection device (100) for detecting damage to a conduit (300) buried in ground includes: a sensor (10) for detecting breaking sound at the time of conduit damage; a processing unit (20) for determining a relation of magnitude between a characteristic value of the breaking sound and a threshold; and an indication unit (30) for indicating that the conduit is damaged when the relation of magnitude satisfies a predetermined condition.

Techniques for performing an acoustic rheology measurement of a sample are provided. A first set of acoustic pulses is provided by a focused ultrasound transducer to induce surface oscillations of the sample. A second set of acoustic pulses is provided by a detection transducer to interrogate the sample and detect the echo pulses reflected by the sample surface as a function of time. The detection ultrasound transducer system converts the echo signals to an electrical signal associated with the detected echo pulses, and a processor determines a dynamic displacement of the interface of the sample as a function of time. The processor also determines the spectrum, resonant surface oscillation frequency, and damping coefficient. Viscoelastic properties of the material are determined from these measurements, with applications for the characterization of the blood clotting process, the identification of a blood clot, gelation process, tumor, or fibrosis based on the viscoelastic properties.

Techniques for performing an acoustic rheology measurement of a sample are provided. A first set of acoustic pulses is provided by a focused ultrasound transducer to induce surface oscillations of the sample. A second set of acoustic pulses is provided by a detection transducer to interrogate the sample and detect the echo pulses reflected by the sample surface as a function of time. The detection ultrasound transducer system converts the echo signals to an electrical signal associated with the detected echo pulses, and a processor determines a dynamic displacement of the interface of the sample as a function of time. The processor also determines the spectrum, resonant surface oscillation frequency, and damping coefficient. Viscoelastic properties of the material are determined from these measurements, with applications for the characterization of the blood clotting process, the identification of a blood clot, gelation process, tumor, or fibrosis based on the viscoelastic properties.

The present invention relates to a nano-dynamic biosensor and a fabrication method therefor. A biosensor according to the present invention comprises a substrate having a hollow structure and a graphene layer formed thereon wherein a probe material is bound to the surface of the graphene layer and the resonance vibration of the hollow structure formed in the substrate is modulated as the probe material increases in weight when a target material to be detected is coupled to the probe material without being labeled, whereby the biosensor is expected to take advantage of the modulation to measure the coupling of the target material including vaccinia virus with high sensitivity on a femtogram (10.sup.−15 g) level.

A micro total analysis system, operating method and manufacturing method thereof are provided. The micro total analysis system includes at least one micro total analysis unit each including: microfluidic device including first electrode and dielectric layer connected to each other, where the dielectric layer drives to-be-measured droplet to move based on voltage of the first electrode; and acoustic wave detection device including second electrode connected to the dielectric layer, where the dielectric layer is also used as transducer of the acoustic wave detection device, and configured to generate acoustic wave toward the droplet based on voltage of the second electrode, and generate a detection result corresponding to the droplet based on received acoustic wave. The micro total analysis system, the operating method and the manufacturing method thereof enables the microfluidic device and the acoustic wave detection device to be integrated in the same chip.

A connector assembly and method of attaching the same to one or more biosensor module boards. The connector assembly includes a body portion defining a first surface and a second surface opposite the first surface. The connector assembly also includes a coaxial RF connector positioned in the body portion and extending between the first surface and the second surface. The coaxial RF connector includes a ground ring, an RF pin positioned within the ground ring, and dielectric therebetween. The connector assembly is configured to be coupled to an RF detection board such that the coaxial RF connector is operably coupled thereto. The connector assembly is also configured to be connected to a biosensor module board such that the coaxial RF connector is operably connected thereto.

A device for determining and/or monitoring a process variable of a medium includes a sensor unit having a mechanically oscillatable unit, a first piezoelectric element, a unit for determining and/or monitoring a temperature of the medium and an electronic system. The device is designed to excite the mechanically oscillatable unit and to receive the mechanical oscillations of the oscillatable unit, to convert them into a first receiving signal, to emit a transmission signal and to receive a second receiving signal, wherein the electronic system is designed to determine the process variable based on the first and/or second receiving signal. The unit for determining and/or monitoring the temperature includes a first and a second temperature sensor arranged at a distance from one another, and the electronic system is designed to determine the temperature of the medium based on a first and/or second temperature receiving signal.

A device for determining and/or monitoring a process variable of a medium includes a sensor unit having a mechanically oscillatable unit, a first piezoelectric element, a unit for determining and/or monitoring a temperature of the medium and an electronic system. The device is designed to excite the mechanically oscillatable unit and to receive the mechanical oscillations of the oscillatable unit, to convert them into a first receiving signal, to emit a transmission signal and to receive a second receiving signal, wherein the electronic system is designed to determine the process variable based on the first and/or second receiving signal. The unit for determining and/or monitoring the temperature includes a first and a second temperature sensor arranged at a distance from one another, and the electronic system is designed to determine the temperature of the medium based on a first and/or second temperature receiving signal.