Described is a mixer for a liquid chromatography system. The mixer includes an inlet, an outlet, a first flow channel, and a second flow channel. The inlet receives a fluid flow to be mixed and the outlet provides the mixed fluid flow. Each of the two flow channels is coupled between the inlet and the outlet. The second flow channel includes an offset volume that delays fluid propagation through the second flow channel relative to the first flow channel. The offset volume includes a coiled channel which increases radial dispersion and decreases axial dispersion of a fluid flowing through the offset volume, thereby enabling a further reduction in periodic noise in a detector baseline signal as compared to known split flow mixers for liquid chromatography systems.

Described is a mixer for a liquid chromatography system. The mixer includes an inlet, an outlet, a first flow channel, and a second flow channel. The inlet receives a fluid flow to be mixed and the outlet provides the mixed fluid flow. Each of the two flow channels is coupled between the inlet and the outlet. The second flow channel includes an offset volume that delays fluid propagation through the second flow channel relative to the first flow channel. The offset volume includes a coiled channel which increases radial dispersion and decreases axial dispersion of a fluid flowing through the offset volume, thereby enabling a further reduction in periodic noise in a detector baseline signal as compared to known split flow mixers for liquid chromatography systems.

An ion suppressor includes ion exchange membranes between a pair of electrodes. Regeneration liquid channels are provided in the spaces between the electrodes and the ion exchange membranes, and an eluent channel is provided between the ion exchange membranes. Ion re-exchange in the eluent on the downstream side of the eluent channel is suppressed, thereby making it possible to improve the detection sensitivity for the ion to be measured. For example, the eluent channel has a folded structure, thereby increasing the amount of current on the downstream side of the eluent channel, and thus, the accumulation of ions is suppressed, and accordingly, ion re-exchange in the eluent can be suppressed.

An ion suppressor includes ion exchange membranes between a pair of electrodes. Regeneration liquid channels are provided in the spaces between the electrodes and the ion exchange membranes, and an eluent channel is provided between the ion exchange membranes. Ion re-exchange in the eluent on the downstream side of the eluent channel is suppressed, thereby making it possible to improve the detection sensitivity for the ion to be measured. For example, the eluent channel has a folded structure, thereby increasing the amount of current on the downstream side of the eluent channel, and thus, the accumulation of ions is suppressed, and accordingly, ion re-exchange in the eluent can be suppressed.

Disclosed are methods, systems, and computer program products for using liquid chromatography/tandem mass spectrometry (LC-MS/MS) for the analysis of endogenous biomarkers, such as 11-oxo androgens, in a sample. The 11-oxo androgens may comprise at least one of 11-hydroxyandrostendione (11OHA), 11-hydroxytestosterone (11OHT) or 11-ketotestosterone (11KT). More specifically, the methods, systems, and computer program products are described for detecting and quantifying the amount of an 11-oxo-androgen in a sample.

A method for preparing chondroitin sulfate oligosaccharides with a C5 protein targeting property, and an application thereof, relating to the technical field of biomedicine. The method uses squid chondroitin sulfate as a raw material to prepare chondroitin sulfate oligosaccharides using enzymatic hydrolysis, using the method to screen the activity of various types of oligosaccharides in order to obtain the fragment with the best activity; the method is highly scientific and feasible. The method further uses the screened chondroitin sulfate disaccharides; the mechanism of chondroitin sulfate disaccharides in the treatment of osteoarthritis by regulating the complement system is explored and revealed by in vitro and in vivo experiments to finally provide a new way of treating osteoarthritis, thus having good practical application value.

A method for preparing chondroitin sulfate oligosaccharides with a C5 protein targeting property, and an application thereof, relating to the technical field of biomedicine. The method uses squid chondroitin sulfate as a raw material to prepare chondroitin sulfate oligosaccharides using enzymatic hydrolysis, using the method to screen the activity of various types of oligosaccharides in order to obtain the fragment with the best activity; the method is highly scientific and feasible. The method further uses the screened chondroitin sulfate disaccharides; the mechanism of chondroitin sulfate disaccharides in the treatment of osteoarthritis by regulating the complement system is explored and revealed by in vitro and in vivo experiments to finally provide a new way of treating osteoarthritis, thus having good practical application value.

A quality control system analyzes the quality of a battery cell, with the battery cell defining a gas pouch configured to expand from a deflated configuration to an inflated configuration when filled with a gas formed during a cell formation process. The system comprises a computational system comprising a processor and a memory and a measurement instrument in electronic communication with the computational system. The measurement instrument is arranged to measure a distance defined by the gas pouch and transmit a signal to the computational system corresponding to the distance. The computational system is arranged to analyze the distance with the processor and determine a volumetric measurement of the gas within the gas pouch and compare the volumetric measurement to a threshold in the memory to assess a quality score for the battery cell. A corresponding method analyzes the quality of the battery cell with the quality control system.

A quality control system analyzes the quality of a battery cell, with the battery cell defining a gas pouch configured to expand from a deflated configuration to an inflated configuration when filled with a gas formed during a cell formation process. The system comprises a computational system comprising a processor and a memory and a measurement instrument in electronic communication with the computational system. The measurement instrument is arranged to measure a distance defined by the gas pouch and transmit a signal to the computational system corresponding to the distance. The computational system is arranged to analyze the distance with the processor and determine a volumetric measurement of the gas within the gas pouch and compare the volumetric measurement to a threshold in the memory to assess a quality score for the battery cell. A corresponding method analyzes the quality of the battery cell with the quality control system.

A method of analyzing the quality of a battery cell includes performing a high-throughput quality check on the battery cell with a quality control system, assessing a quality score to the battery cell, with quality score identifying the battery cell as low-quality or high-quality, and performing a comprehensive quality check on the battery cell if identified as low-quality. The method further includes assessing an enhanced quality score to the battery cell superseding the quality score of the quality control system identifying the battery cell as confirmed low-quality or confirmed high-quality and providing revised production instructions for manufacturing successive battery cells if confirmed low-quality.