The disclosure relates to systems and methods for detecting and correcting errors in pH meter calibration or function when changing the pH of a sample, comprising measuring an initial pH, adding two or more amounts of titrant and measuring corresponding pH values, and applying a model to determine if the measured pH values correspond to pH values predicted by the model. The systems and methods can be used to control pH during viral inactivation of protein samples.

The disclosure relates to systems and methods for controlling the pH of a sample, comprising measuring an initial pH, adding an amount of titrant and measuring a second pH, and using non-dimensional modeling to normalize titrant and determine the amount of titrant needed to reach a final pH. The systems and methods can be used to control pH during viral inactivation or titration of protein samples.

The disclosure relates to systems and methods for controlling the pH of a sample, comprising measuring an initial pH, adding an amount of titrant and measuring a second pH, and using non-dimensional modeling to normalize titrant and determine the amount of titrant needed to reach a final pH. The systems and methods can be used to control pH during viral inactivation or titration of protein samples.

Systems and methods for this disclosure describe systems and methods that are directed to monitoring active clay in water-based drilling fluid may be provided. A method for monitoring active clay concentration while drilling may be provided. The method may include providing a sample of water-based drilling fluid. The method may further include adding methylene blue to the sample in a methylene blue titration. The method may further include performing an impedance measurement on the sample during the methylene blue titration. The method may further include determining an endpoint of the methylene blue titration using a phase angle measurement from the impedance measurement. The method may further include correlating the endpoint to the active clay concentration of the sample. The method may further include determining a treatment for the water-based drilling fluid based on the active clay concentration.

Systems and methods for this disclosure describe systems and methods that are directed to monitoring active clay in water-based drilling fluid may be provided. A method for monitoring active clay concentration while drilling may be provided. The method may include providing a sample of water-based drilling fluid. The method may further include adding methylene blue to the sample in a methylene blue titration. The method may further include performing an impedance measurement on the sample during the methylene blue titration. The method may further include determining an endpoint of the methylene blue titration using a phase angle measurement from the impedance measurement. The method may further include correlating the endpoint to the active clay concentration of the sample. The method may further include determining a treatment for the water-based drilling fluid based on the active clay concentration.

A system for titrating a solution is provided. The system includes a robotic arm, a titrator, a solution pump, an infusion pump, a scale, and an Autonomous cup dryer Carousel/Carriage. The system further includes a computer having a memory and a processor. The computer may be a programmable logic controller. The processor of the computer activates the solution pump to pump a solution into a drip chamber, directs the robotic arm to place a cup on the scale, activates the infusion pump to drip the solution from the drip chamber into the cup until a threshold weight has been reached, and directs the robotic arm to transport the cup to the titrator.

A system for titrating a solution is provided. The system includes a robotic arm, a titrator, a solution pump, an infusion pump, a scale, and an Autonomous cup dryer Carousel/Carriage. The system further includes a computer having a memory and a processor. The computer may be a programmable logic controller. The processor of the computer activates the solution pump to pump a solution into a drip chamber, directs the robotic arm to place a cup on the scale, activates the infusion pump to drip the solution from the drip chamber into the cup until a threshold weight has been reached, and directs the robotic arm to transport the cup to the titrator.

A system for titrating liquids, with a syringe or tip, comprising a holding device and at least one tag and a metering equipment, comprising an additional holding device for holding the syringe or tip on the holding device, a reading device for reading the tag of the syringe or tip held by the additional holding device, a driving device having a motor, which is detachably coupled with a plunger of the syringe when the same is held by the additional holding device, or which is coupled with a plunger which is arranged in a cylinder which is coupled with the tip via a fluid conduit, when the same is held by the additional holding device, an operating device for operating the metering equipment and a control device, connected with the operating device, the reading device and the driving device, which controls the movement of the plunger depending of the tag of the inserted syringe or tip.

A system for titrating liquids, with a syringe or tip, comprising a holding device and at least one tag and a metering equipment, comprising an additional holding device for holding the syringe or tip on the holding device, a reading device for reading the tag of the syringe or tip held by the additional holding device, a driving device having a motor, which is detachably coupled with a plunger of the syringe when the same is held by the additional holding device, or which is coupled with a plunger which is arranged in a cylinder which is coupled with the tip via a fluid conduit, when the same is held by the additional holding device, an operating device for operating the metering equipment and a control device, connected with the operating device, the reading device and the driving device, which controls the movement of the plunger depending of the tag of the inserted syringe or tip.

There is provided plate equipped with a mechanism to facilitate determination of the amount of a fluid added to or removed from a well in the plate. Other embodiments are also described.