A mechanism (10) for an automated Karl Fischer (KF) titration system (1) includes a support console (6), a first vertical guide rail element (11), solidly attached to the support console, and a carriage unit (12), slidably constrained to the first vertical guide rail element, allowing the carriage unit a first degree of linear vertical mobility relative to the support console. The carriage unit holds a vial lift unit (13) with a lift platform (14) for a sample vial (18). The carriage unit, in a downward movement phase, lowers the lift platform from a starting position into an oven cavity of the titration system. A subsequent upward movement phase raises the lift platform to the starting position. A second vertical guide rail element, solidly connected to the lift platform and slidably constrained to the carriage unit, enables a second degree of linear vertical mobility of the lift platform.

A method for determining a concentration of a chemical of interest in a recirculating analyte system includes the steps of selecting a first indicator threshold, measuring the flow rate of the recirculating analyte system, controllably adding a known amount of reagent to the recirculating analyte system at an known flow rate, repetitively measuring an indicator of the recirculating analyte system downstream from the addition of the reagent, and computing the concentration of the chemical of interest of the recirculating analyte system when the indicator measurement crosses the indicator threshold.

Systems and methods for this disclosure describe systems and methods that are directed to monitoring active clay in water-based drilling fluid may be provided. A method for monitoring active clay concentration while drilling may be provided. The method may include providing a sample of water-based drilling fluid. The method may further include adding methylene blue to the sample in a methylene blue titration. The method may further include performing an impedance measurement on the sample during the methylene blue titration. The method may further include determining an endpoint of the methylene blue titration using a phase angle measurement from the impedance measurement. The method may further include correlating the endpoint to the active clay concentration of the sample. The method may further include determining a treatment for the water-based drilling fluid based on the active clay concentration.

Systems and methods for this disclosure describe systems and methods that are directed to monitoring active clay in water-based drilling fluid may be provided. A method for monitoring active clay concentration while drilling may be provided. The method may include providing a sample of water-based drilling fluid. The method may further include adding methylene blue to the sample in a methylene blue titration. The method may further include performing an impedance measurement on the sample during the methylene blue titration. The method may further include determining an endpoint of the methylene blue titration using a phase angle measurement from the impedance measurement. The method may further include correlating the endpoint to the active clay concentration of the sample. The method may further include determining a treatment for the water-based drilling fluid based on the active clay concentration.

A method for recalculating the solvent power of a light oil, SP.sub.(LO recalculated), is provided. The method comprises: titrating the light oil against a reference oil, optionally in the presence of a titrant, to determine a volume fraction of the light oil at the onset of asphaltene precipitation, V.sub.(onset fraction LO), a volume fraction of the reference oil at the onset of asphaltene precipitation, V.sub.(onset fraction RO), and, where a titrant is present, a volume fraction of the titrant at the onset of asphaltene precipitation, V.sub.(onset fraction T), and determining the recalculated solvent power of the light oil, SP.sub.(LO recalculated), according to the following formula: ${\mathrm{SP}}_{\left(\mathrm{LO}\mathrm{recalculated}\right)}=\frac{(\begin{array}{c}{\mathrm{CSP}}_{\left(\mathrm{RO}\right)}-{\mathrm{SP}}_{\left(\mathrm{RO}\right)}*V_{\left(\mathrm{onset}\mathrm{fraction}\mathrm{RO}\right)}-\\ x*{\mathrm{SP}}_{\left(T\right)}\end{array}}{}$

A method for recalculating the solvent power of a light oil, SP.sub.(LO recalculated), is provided. The method comprises: titrating the light oil against a reference oil, optionally in the presence of a titrant, to determine a volume fraction of the light oil at the onset of asphaltene precipitation, V.sub.(onset fraction LO), a volume fraction of the reference oil at the onset of asphaltene precipitation, V.sub.(onset fraction RO), and, where a titrant is present, a volume fraction of the titrant at the onset of asphaltene precipitation, V.sub.(onset fraction T), and determining the recalculated solvent power of the light oil, SP.sub.(LO recalculated), according to the following formula: ${\mathrm{SP}}_{\left(\mathrm{LO}\mathrm{recalculated}\right)}=\frac{(\begin{array}{c}{\mathrm{CSP}}_{\left(\mathrm{RO}\right)}-{\mathrm{SP}}_{\left(\mathrm{RO}\right)}*V_{\left(\mathrm{onset}\mathrm{fraction}\mathrm{RO}\right)}-\\ x*{\mathrm{SP}}_{\left(T\right)}\end{array}}{}$

The present invention provides, among other things, devices, methods and applications of collecting, preserving, transporting, and analyzing tiny body fluids which have targeted biomarkers.

An analytical device has an oven arrangement (1) with an oven (2), an insulation system, a ventilation system and a housing. The ventilation system has a first convection system that uses natural convection, arranged to keep the housing cool, as well as a second convection system that uses forced convection, arranged to reduce the temperature in the oven (2). In particular, the analytical device is a component of a Karl Fischer titration instrument.

In one example in accordance with the present disclosure, a fluidic ejection system is described. The fluidic ejection system includes a frame to retain a number of fluidic ejection devices. The frame has a form factor to match a titration plate. The fluidic ejection system also includes the number of fluidic ejection devices disposed on the frame. Each fluidic ejection device includes a reservoir disposed on a first side of the frame and a fluidic ejection die disposed on an opposite side of the frame. Each fluidic ejection die includes an array of nozzles, with each nozzle including an ejection chamber, an opening, and a fluid actuator disposed within the ejection chamber.

In one example in accordance with the present disclosure, a fluidic ejection system is described. The fluidic ejection system includes a frame to retain a number of fluidic ejection devices. The frame has a form factor to match a titration plate. The fluidic ejection system also includes the number of fluidic ejection devices disposed on the frame. Each fluidic ejection device includes a reservoir disposed on a first side of the frame and a fluidic ejection die disposed on an opposite side of the frame. Each fluidic ejection die includes an array of nozzles, with each nozzle including an ejection chamber, an opening, and a fluid actuator disposed within the ejection chamber.