The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides. The technology still more particularly relates to automated devices for carrying out pipetting operations, particularly on samples in parallel, consistent with sample preparation and delivery of PCR-ready nucleotide extracts to a cartridge wherein PCR is run.

Method and apparatus are provided for processing a sample on a slide. A capillary processing module has a crank to raise and lower a slide, and/or a side inlet to apply a fluid to the slide. A capillary gap is formed between the slide and a chamber floor of the capillary processing module when the crank has lowered the slide. Capillary action causes the fluid to spread through the capillary space across a processing area and to contact the sample. When the crank raises the slide, the fluid is withdrawn from the processing area of the slide because the capillary gap is eliminated.

An automated analyzer includes an analysis operation part that causes a sample and a reagent to react and based on the reaction result performs analysis of the sample, wherein: the automated analyzer includes a plurality of units constituting the analysis operation part, a temperature adjustment mechanism that heats or cools the units, a temperature sensor that measures the temperature of the units, and a control part that controls the temperature adjustment mechanism. The control part sets the measurement startable temperature range of each unit, which is the temperature range of the operation specification thereof, and the operable temperature range, which is a temperature range that is wider than the measurement startable temperature range, and starts the analysis process of the sample when the temperature of each unit has entered the operable temperature range.

Devices and methods for inspecting containers for the presence of foreign matter include, in at least one embodiment, at least one sampling head, at least one pressure sensor, and a filter. The at least one sampling head is configured to introduce an amount of a first fluid into a container and to remove an amount of a second fluid from the container for inspection for the presence of foreign matter. The at least one pressure sensor is configured to measure a pressure of the second fluid upon removal of the second fluid from the container. The filter is arranged in the at least one sampling head and is configured to filter the second fluid.

Exemplary embodiments provide computer-implemented methods, mediums, and apparatuses configured to provide an interactive analytical method debugger for an analytical laboratory system. The analytical laboratory system may include a laboratory analytical device with a number of settings, parameters, etc. The laboratory analytical device may process a sample according to an analytical method that (among other things) defines a configuration for the device. The settings for the method may be organized into categories. The interactive debugger identifies problems with the method (e.g., incompatibilities, values out of range, etc.) and automatically allow the user to view the category of the method that is relevant to addressing the issue. Possible solutions may be proposed in the debugger interface, allowing the user to quickly identify and address the problem. Embodiments are particularly well-suited to situations where a method is ported from an old device to a new device.

A real-time online analysis device for substance pyrolysis, including: a pyrolyzing system (1), a capturing system (2), a testing system (3) and a controlling system (4) is disclosed. The pyrolyzing system (1), the capturing system (2) and the testing system (3) are connected with the controlling system (4). The capturing system (2) has a cooling cavity (22) and a heating cavity (23) inside. The temperature of the cooling cavity (22) ranges from room temperature to −200° C., and the temperature of the heating cavity (23) ranges from room temperature to 1000° C. A method for real-time online analysis of substance pyrolysis using the device is also disclosed. The present device can provide real-time online pyrolysis, capturing, separation and analysis of substances at a plurality of temperature points or ranges.

As a standard solution for evaluating a scattered light measuring optical system mounted on an automated analyzer, a standard solution containing an insoluble carrier at a concentration, at which transmittance is in a range of 10% to 50%, is used, and a light quantity of a light source is adjusted such that a scattered light detector outputs a predetermined value.

A flexible instrument control and data storage/management system and method for representing and processing assay plates having one or more predefined plate locations is disclosed. The system utilizes a graph data structure, layer objects and data objects. The layer objects map the graph data structure to the data objects. The graph data structure can comprise one node for each of the one or more predefined plate locations, wherein the nodes can be hierarchically defined according to a predefined plate location hierarchy. Each node can be given a unique node identifier, a node type and a node association that implements the predefined plate location hierarchy. The layer objects can include an index that maps the node identifiers to the data objects.

A device for separating one or more molecules of interest in a liquid specimen including a monolithic body defining a fractionation column. The column includes an inlet opening at a proximal end of the fractionation column; an outlet opening at a distal, opposite end of the fractionation column; a solid phase chamber positioned between the inlet opening and the outlet opening; a specimen introduction area adjacent a proximal end of the solid phase chamber; an analyte exit area adjacent a distal end of the solid phase chamber; an inlet chamber adjacent the inlet opening that tapers into the specimen introduction area; and an outlet chamber that extends from the analyte exit area to the outlet opening. A metered amount of solid phase packed within the solid phase chamber between a first porous frit and a second porous frit of the solid phase chamber.

Provided is an automatic analysis device capable of obtaining a stable light intensity over a wide wavelength band by multiplexing a plurality of LED lights and adjusting the temperature characteristics of each LED element. The automatic analysis device according to the present disclosure is configured such that light emitted from a second LED is reflected to be multiplexed on the same optical axis as the light emitted from a first LED, and the first LED and the second LED are in contact with the same temperature adjustment member.