A target substance is collected from a composition by using magnetically responsive particles and a magnetic transfer probe. The composition may be prepared, e.g., by introducing magnetically responsive particles to a sample. The particles selectively bind to a target substance of the composition. The target substance and the particles are collected from the sample by using the magnetic transfer probe, which comprises a probe magnet. The probe magnet is a permanent magnet, which comprises a cylindrical portion and a convex bottom portion adjoining the cylindrical portion. The particle collection region of the magnetic transfer probe is at a low position, which allows collecting the particles from a small amount of the prepared composition.

Provided is an automatic analyzer that reduces a risk of damage due to contact with a stirring paddle during maintenance and the like, and realizes miniaturization and simplification. A cleaning tank 181 configured to clean the stirring paddle, a standby position 182 configured to make the stirring paddle which is juxtaposed to the cleaning tank wait, and an inflow port 183 configured to flow cleaning water into the cleaning tank are provided, and the standby position 182 is arranged so that the cleaning water overflowing from the cleaning tank 181 overflows 194 to the standby position 182.

The present invention relates to an immunoassay apparatus and a method thereof. The immunoassay apparatus including a cartridge 13 in which a tube for T tip 9, a reaction tube 11, a tube for washing 3, and a tube for signal measurement 5 are integrally coupled or individually configured; a T tip 7 and a magnetic rod 31 used for performing reaction and washing processes while moving large magnetic particles m, capture materials, signal materials, and analyte materials with magnetic force by entering successively a plurality of tubes 3 and 5; a cartridge holder 15 in which the cartridge 13 is seated; and a heating member 17 that generates heat by being disposed at a region in which the reaction tube 11 is seated in the cartridge holder 15; is configured in a state where each of the different shapes of magnetic particles is bound with materials.

Disclosed is a fully-automatic chemiluminescence immunoassay analyzer, which comprises a base, a reaction cup conveyance module, a robot-arm sample injection module, an incubation module, a manipulator and transit module, a magnetic-separation cleaning module, and a detection module are mutually independently integrated on the base. The reaction cup conveyance module is used for conveying a reaction cup to a pre-determined position; the manipulator and transit module carries the reaction cup into the incubation module, to incubate the reaction cup for a constant-temperature reaction; the reaction cup in the incubation module is carried to the magnetic-separation cleaning module for magnetic-adsorption cleaning; and the reaction cup after cleaning is carried by the manipulator and transit module to the detection module for detection. A plurality of manipulators and a plurality of transit devices may be disposed as required, to link the mutually independent functional parts of the modules. Further, the instrument may be equipped with detection modules and process modules of various detection platforms, which cooperate with the manipulator and transit module to realize diverse detection in a table-top production line manner.

A method for performing a magnetic separation procedure that includes transporting a receptacle containing a fluid medium to a first location of a system, where the fluid medium contains both a sample material and a suspension of magnetically-responsive solid supports. At the first location, the fluid medium is exposed to a first magnetic field for a first dwell period, thereby isolating the solid supports within the receptacle, where no portion of the fluid medium is removed from the receptacle at the first location. The receptacle is then transported from the first location to a second location of the system, where the fluid medium is exposed to a second magnetic field for a second dwell period. Following the second dwell period, at least a portion of the fluid medium is removed from the receptacle. A suspension fluid is then dispensed into the receptacle, and the contents of the receptacle are agitated to suspend the solid supports within the suspension fluid.

An object is to provide an automatic analyzer that prevents an effect of various environmental changes on an equilibrium state of an immunological binding reaction. An automatic analyzer of an embodiment of the invention includes a B/F separation unit that executes a B/F separation step separating an unreacted component and a reacted component from a liquid in which a sample and a reagent are reacted, a detection unit that detects a reacted component in the liquid after the B/F separation step, and a temperature maintaining unit that maintains the B/F separation unit and the detection unit in substantially the same temperature environment.

The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.

The present disclosure relates to a cleaning device and a chemiluminescence detector. A cleaning device is provided with a cup inlet station and a cup outlet station, wherein the cleaning device comprises a pedestal, a plurality of magnetic adsorption components, a turntable arranged on the pedestal, and a primary cleaning mechanism arranged on the pedestal, wherein each of the plurality of magnetic adsorption components comprises a plurality of magnets; magnetic adsorption heights of a plurality of magnets of the first magnetic adsorption component are equal and are recorded as A; magnetic adsorption heights of a plurality of magnets of the middle magnetic adsorption component are equal and are recorded as B, and B>A.

An automatic analysis apparatus and an operating method for the automatic analysis apparatus. At least two magnetic separation units are introduced, each magnetic separation unit operating independently and being used for performing magnetic separation cleaning on a reaction solution in a reaction cup. Each magnetic separation unit may be used for any magnetic separation cleaning step in a one-step test project or a multi-step test project, thereby significantly increasing the test speed and the test throughput of the automatic analysis apparatus.

Provided are a flow cell and an automatic analysis device which are excellent in the long-term stability of the flow path shape of the flow cell and can improve the reproducibility of analysis. The flow cell (6) of the present invention includes a base (18) including an inlet and outlet (35, 36) for a flow path of a reaction solution containing an analyte; an electrode (16A, 16B) for applying a voltage to the analyte; a light receiving window (22) made of a member that transmits light emitted from the analyte by the voltage applied on the electrode, a gasket (18A) provided between the base (18) and the light receiving window (22), and a flow chamber (17) surrounded by the base (18), the light receiving window (22) and the gasket (18A), in which the gasket (18A) has a deformation amount of 0 mm or more and 0.2 mm or less in a chemical immersion test, and the surface adhesive force of 14 N/cm.sup.2 or more and 40 N/cm.sup.2 or less in a surface adhesion evaluation