The invention relates to a diffractive device (18) for chemical and biological analysis based on structured receptors on waveguides, which comprises: a waveguide (1) and a recognition element (3) consisting of a grating with receptors (11) arranged on the waveguide (1) and are intended to interact with target compounds (12) present in a sample; and a radiation source (4) that emits an incident beam (5) propagated through the waveguide (1), interacting with the recognition element (3) and being diffracted according to Bragg's law, thereby generating a reflected beam (6) and a transmitted beam (7), which are collected by optical analysers (8, 17) that record parameters of the reflected beam (6) and of the transmitted beam (7), enabling multiple analyses to be conducted in a simple, fast, sensitive and quantitative manner, label-free and in real time.

A dual optical frequency comb generator incudes a semiconductor substrate, a first optical frequency comb laser light source including a first resonator, a second optical frequency comb laser light source including a second resonator and differing in repetition frequency of optical pulses from the first optical frequency comb laser light source, two or more outputters including first and second outputters, a first optical waveguide connecting the first optical frequency comb laser light source with the first outputter, a second optical waveguide connecting the second optical frequency comb laser light source with the second outputter, and a third optical waveguide that branches off from the first optical waveguide and joins the second optical waveguide. The first optical frequency comb laser light source, the second optical frequency comb laser light source, the two or more outputters, and the optical waveguides are integrated on the semiconductor substrate.

A nucleic acid amplification in-situ real-time detection system and method using a micro-fluidic chip through optical fiber sensing. The system includes a white light source, a detection optical path, a microfluidic chip and a spectrum acquisition, processing and display module, which are connected in sequence. The detection optical path is configured to transmit white light from the white light source to the micro-fluidic chip and transmit an optical signal made by the microfluidic chip to the spectrum acquisition, processing and display module. The micro-fluidic chip is configured to carry out biochemical reaction; the spectrum acquisition, processing and display module is configured to acquire the optical signal, analyze the signal and generate a visual biochemical reaction real-time dynamic-change signal curve. This microfluidic chip real-time detection device detects nucleic acid amplification information by using a white light interfered hyperspectral method, so fluorescence-labeled analyte and non-fluorescence-labeled analyte are detected.

The invention relates to a photometer (30) for analysing the composition of a sample gas. The photometer comprises an infra-red (IR) source (20) configured to direct a first plurality of pulses (40) of IR radiation through the sample gas to an IR detector (26), at least two of the first plurality of pulses being of different wavelength. The photometer further comprises an ultraviolet (UV) source (32) configured to generate a second plurality of pulses (38) of UV radiation for conveyance to a UV detector (36), at least two of the second plurality of pulses being of different wavelength. A path selection arrangement (22, 42-50) is configured to selectively convey different ones of the second plurality of pulses (38) to one of the sample gas and the UV detector (36). The photometer further comprises processing circuitry coupled to the IR source (20), the UV source (32), the IR detector (26), the UV detector (36) and the path selection arrangement (22, 42-50). The processing circuitry is configured to (i) select the wavelength to be used for a given UV pulse of the second plurality of pulses (38), (ii) receive a plurality of detection signals from each of the IR detector (26) and the UV detector (36) and (iii) based on the detection signals, determine a concentration of at least one component of the sample gas. A method for analysing the composition of a sample gas is also disclosed.

A spectroscope using single-photon counters and a chip-integrated lithium niobate micro-ring filter to measure the atmospheric CO2 absorption spectrum passively is disclosed. By thermo-optically sweeping the filter over 150 pm and referencing the resulting photon counts to a bypass channel, the absorption spectrum can be sampled at an ultrahigh-resolution of 6 pm. The spectroscope can be a part of a ground-based field system, wherein the CO2 absorption through the atmosphere can be characterized by counting the solar photons across the absorption line around 1572.02 nm, which agrees well with its transmission spectrum at standard atmospheric pressure.

A biological material measuring instrument is described. The biological material measuring instrument includes a rotating body and a main body. The rotating body includes one or more cartridge holders having cuvettes in which a reagent and an analyte in a sample react. The main body includes a pair of light-emitting parts and light-receiving parts to optically measure the analyte in the sample. The rotating body further includes a light-emitting optical waveguide for guiding the light of the light-emitting parts to the cuvette, and a light-receiving optical waveguide for guiding.

A method for measuring process parameters in liquid cultures in a plurality of microreactors of at least one microtiter plate includes continuously agitating the liquid cultures using an orbital agitator at least until the reaction is completed in all the microreactors. In order to allow process parameters also of such substances which themselves do not have any fluorescence activity to be measured with relatively low complexity and within a short time, 2D fluorescence spectra are recorded in a plurality of in particular different liquid cultures in the microreactors of agitated microplates. A device for carrying out the method is also disclosed.

Provided is an optical probe, and a Raman spectroscopy system using such, including excitation and detection optics coupled to a sampling optics via a beam splitter, in confocal arrangement with a sample focal plane of the sampling optics. The detection optics is arranged to receive Raman signal from the sample focal plane and direct it onto a tip of a detection optical fiber. The optical probe may further include a positioning device mechanically coupled to the sampling optics and configured to control a position of the sample focal plane. In the Raman spectroscopy system a light source is coupled to the excitation optics via an excitation optical fiber, and a spectrometer is coupled to a detection optics via a detection optical fiber. Provided is further a method for measuring Raman signal depth profile in a sample, wherein sample's Raman spectra is measured and stored at different focal plane positions.

Spectrophotometer system configured to characterize and/or measure spectrally (wavelength)-dependent properties of material components (such as molecular, viral, and/or bacterial analytes) associated with or of an object prior to the time when optical fingerprints of such material components start to degrade, and associated methods. System can be enhanced by a capability of selecting specific wavelengths of operation for such system to optimize cost-efficiency of the system.

A measurement system is provided with an array of laser diodes with one or more Bragg reflectors. At least a portion of the light generated by the array is configured to penetrate tissue comprising skin. A detection system configured to: measure a phase shift, and a time-of-flight, of at least a portion of the light from the array of laser diodes reflected from the tissue relative to the portion of the light generated by the array; generate one or more images of the tissue; detect oxy- or deoxy-hemoglobin in the tissue; non-invasively measure blood in blood vessels within or below a dermis layer within the skin; measure one or more physiological parameters based at least in part on the non-invasively measured blood; and measure a variation in the blood or physiological parameter over a period of time.