A multi-modality imaging system allows for selectable photoelectric effect and/or Compton effect detection. The camera or detector is a module with a catcher detector. Depending on the use or design, a scatter detector and/or a coded physical aperture are positioned in front of the catcher detector relative to the patient space. For low energies, emissions passing through the scatter detector continue through the coded aperture to be detected by the catcher detector using the photoelectric effect. Alternatively, the scatter detector is not provided. For higher energies, some emissions scatter at the scatter detector, and resulting emissions from the scattering pass by or through the coded aperture to be detected at the catcher detector for detection using the Compton effect. Alternatively, the coded aperture is not provided. The same module may be used to detect using both the photoelectric and Compton effects where both the scatter detector and coded aperture are provided with the catcher detector. Multiple modules may be positioned together to form a larger camera, or a module is used alone. By using modules, any number of modules may be used to fit with a multi-modality imaging system. One or more such modules may be added to another imaging system (e.g., CT or MR) for a multi-modality imaging system.

A non-transitory computer-readable medium stores instructions readable and executable by a workstation (18) including at least one electronic processor (20) to perform an image reconstruction method (100) to reconstruct list mode data acquired over a frame acquisition time using a plurality of radiation detectors (17) in which the events of the list mode data is timestamped. The method includes: for the sub-frame bins of a plurality of sub-frame bins into which the frame acquisition time is divided, determining a sub-frame singles rates map for the plurality of radiation detectors from the list mode data whose time stamps reside in the sub-frame bin; determining a singles rate for the singles events of the list mode data using the sub-frame singles rates maps wherein the singles rates for the singles events are determined at a temporal resolution that is finer than the frame acquisition time; determining correction factors for the list mode data using the determined singles rates for the singles events of the list mode data; and reconstructing the list mode data of the frame acquisition time using the determined correction factors to generate a reconstructed image for the frame acquisition time.

The disclosed embodiments relate to a system that performs ultra-fast tracer imaging on a subject using positron emission tomography. During operation, the system performs a high-temporal-resolution, total-body dynamic PET scan on the subject as an intravenously injected radioactive tracer propagates through the vascular system of the subject to produce PET projection data. Next, the system applies an image reconstruction technique to the PET projection data to produce subsecond temporal frames, which illustrate the dynamic propagation of the radioactive tracer through the vascular system of the subject. Finally, the system outputs the temporal frames through a display device.

An apparatus for characterizing a focused charged beam is provided. The apparatus includes a plurality of parallel conducting channels and at least one current sensing unit configured to measure current across each of the plurality of parallel conducting channels.

Provided are a radiation detector, a radiographic imaging apparatus, and a manufacturing method that include a TFT substrate in which a plurality of pixels that accumulate electric charges generated depending on light converted from radiation are formed in a pixel region of a first surface of a flexible base material and a terminal region of the first surface is provided with a terminal for electrically connecting a flexible cable; a conversion layer that is provided outside the terminal region on the first surface of the base material to convert the radiation into light; a first reinforcing substrate that is provided on a surface of the conversion layer opposite to a surface on a TFT substrate side and has a higher stiffness than the base material; and a second reinforcing substrate that is provided on a second surface of the base material opposite to the first surface to cover a surface larger than the first reinforcing substrate, and that are capable of suppressing that a defect occurs in the substrate and have an excellent peeling property in a reworking process.

Some embodiments are directed to a radiation dosage monitoring system including a model generation module configured to generate a 3D surface model of a portion of a patient undergoing radiation treatment, an image detector configured to detect Cherenkov radiation and any subsequent secondary and scattered radiation originating due to the initial Cherenkov radiation emitted from the patient, a processing module configured to determine estimations of radiation applied to the patient utilizing the images from the image detector and the 3D model, and to utilize the determined estimations of radiation applied to the patient together with data indicative of the orientation of a radiation beam inducing emission of the Cherenkov radiation at a time when the radiation beam was applied to generate a 3D internal representation of the location of the portions of a irradiated patient resulting in the emission of the Cherenkov radiation.

Some embodiments are directed to a radiation dosage monitoring system including a model generation module configured to generate a 3D surface model of a portion of a patient undergoing radiation treatment, an image detector configured to detect Cherenkov radiation and any subsequent secondary and scattered radiation originating due to the initial Cherenkov radiation emitted from the patient, a processing module configured to determine estimations of radiation applied to the patient utilizing the images from the image detector and the 3D model, and to utilize the determined estimations of radiation applied to the patient together with data indicative of the orientation of a radiation beam inducing emission of the Cherenkov radiation at a time when the radiation beam was applied to generate a 3D internal representation of the location of the portions of a irradiated patient resulting in the emission of the Cherenkov radiation.

Embodiments are directed generally to an ionizing-radiation beamline monitoring system that includes a vacuum chamber structure with vacuum compatible flanges through which an incident ionizing-radiation beam enters the monitoring system. Embodiments further include at least one scintillator within the vacuum chamber structure that can be at least partially translated in the ionizing-radiation beam while oriented at an angle greater than 10 degrees to a normal of the incident ionizing-radiation beam, a machine vision camera coupled to a light-tight structure at atmospheric/ambient pressure that is attached to the vacuum chamber structure by a flange attached to a vacuum-tight viewport window with the camera and lens optical axis oriented at an angle of less than 80 degrees with respect to a normal of the scintillator, and at least one ultraviolet (“UV”) illumination source facing the scintillator in the ionizing-radiation beam for monitoring a scintillator stability comprising scintillator radiation damage.

A position-sensitive ionizing-particle radiation counting detector includes a first substrate and a second substrate generally parallel to the first substrate and forming a gap with the first substrate, with a discharge gas contained within the gap. The detector includes a first electrode electrically coupled to the second substrate, and a second electrode electrically coupled to the first electrode and defining at least one pixel with the first electrode. The detector further includes an open dielectric structure pattern layered over one of the first or second electrodes and a current-limiting quench resistor coupled in series to one of the first or second electrodes. The detector further includes a power supply coupled to one of the first or second electrodes and a first discharge event detector circuitry coupled to the one of the first or second electrodes for detecting a gas discharge counting event in the electrode.

Disclosed herein is an image sensor comprising: a plurality of radiation detectors; a mask with a plurality of radiation transmitting zones and a radiation blocking zone; and an actuator configured to move the plurality of radiation detectors from a first position to a second position and to move the mask from a third position to a fourth position; wherein while the radiation detectors are at the first position and the mask is at the third position and while the radiation detectors are at the second position and the mask is at the fourth position, the radiation blocking zone blocks radiation from a radiation source that would otherwise incident on a dead zone of the image sensor and the radiation transmitting zones allow at least a portion of radiation from the radiation source that would incident on active areas of the image sensor to pass through.