Disclosed herein is a method comprising: capturing a first image of a tissue using radiation; selecting a region of the tissue based on the first image; capturing a second image of the tissue in the region using the radiation; wherein a signal-to-noise ratio of the second image is higher than a signal-to-noise ratio of the first image.

To provide a technique with which it is possible to make collimator plates resistant to deformation, and reduce position offsets in the collimator plates, a collimator module (1) comprises a plurality of collimator plate sets (2) lined up side by side in a channel direction (CH), wherein each collimator plate set (2) comprises a first collimator plate (3), a second collimator plate (4), and a joint layer (5) disposed between the first collimator plate (3) and second collimator plate (4) for adhesively bonding the first collimator plate (3) and second collimator plate (4) together, and the plurality of collimator plate sets (2) are lined up side by side in the channel direction (CH) with an air layer (20) intervening between adjacent two of the plurality of collimator plate sets (2).

A computer-implemented method for generating a motion corrected image is provided. The method includes receiving listmode data collected by an imaging system; producing two or more histo-image frames or two or more histo-projection frames based on the listmode data; providing the two or more histo-image frames or two or more histo-projection frames to an Artificial Intelligence (AI) system; receiving two or more AI reconstructed images from the AI system based on the two or more histo-image frames or the two or more histo-projection frames; and generating a motion estimation in reconstructed images by using a motion free AI reconstructed image frame as a reference frame.

A method of detecting radiation from a source and a radiation detection system embodying the principles of the method are described. The method comprises: positioning a detector to receive radiation from the source; applying a multiplexing transformation to radiation from the source to create complexity in three dimensions in the pattern of radiation from the source; receiving a plurality of responses each being a response to an interaction with incident radiation occurring within the detector; determining, for each of the plurality of responses, a characteristic of the interaction, wherein the characteristic comprises at least a position in three dimensions of the interaction within the detector; processing the said plurality of responses in accordance with the determined position in three dimensions of each interaction within the detector and drawing inferences therefrom regarding the pattern of radiation from the source.

The present disclosure relates to an insert system for performing positron emission tomography (PET) imaging. The insert system can be reversibly installed to an existing system, such that PET functionality can be introduced into the existing system without the need to significantly modify the existing system. The present disclosure also relates to a multi-modality imaging system capable for conducting both PET imaging and magnetic resonance imaging (MRI). The PET and MRI imaging can be performed simultaneously or sequentially, while the performance of neither imaging modality is compromised for the operation of the other imaging modality.

The present invention relates to a Compton imaging apparatus and a single photon emission and positron emission tomography system comprising the Compton imaging apparatus and, more specifically, to a Compton imaging apparatus based on a single scintillator and a single photon emission and positron emission tomography system including the Compton imaging apparatus. The Compton imaging apparatus according to the present invention may reconstruct a Compton image based on the single scintillator composed of a plurality of scintillation cells. Thus, the Compton imaging apparatus of the present invention is cheaper than any other Compton imaging apparatuses and has an excellent time resolution such that the Compton imaging apparatus can be used even in a high-radiation area. Also, the single photon emission and positron emission tomography system using the Compton imaging apparatus can improve radiation detection efficiency and an image resolution, to thereby improve image quality.

The present disclosure provides devices, systems, and methods for time correction. The device may include a first time measurement component configured to measure a receiving time of a valid signal; a correction component configured to collect correction information for correcting the receiving time of the valid signal; and a processing device configured to determine a corrected receiving time of the valid signal by correcting the receiving time of the valid signal based on the correction information.

A device for the detection of gamma rays used primarily in a PET scanner is based on a scintillator heterostructure combining the high stopping power of scintillators commonly used in PET scanners (such as L(Y)SO, BGO, etc.) and very fast scintillators based on polymers loaded with fast emitting dyes or nanocrystals, or thin layers of nanocrystals or multiple quantum well structures. The particular arrangement of this detector module allows combining all the important features of a high-performance Time-of-Flight PET (TOFPET) detector module, i.e., a high photoelectric detection efficiency for the gamma rays, a precise 3D information (including the depth of interaction DOI) of the gamma ray conversion in the module, and good energy resolution.

In one aspect, a radiation detector is disclosed, which includes a substrate having a plurality of microcapillary channels, and a crystalline scintillator material disposed in said channels so as to generate a plurality of independent radiation sensing elements associated with each channel for detecting incident radiation and generating an optical radiation in response to the detection of the incident radiation. In some embodiments, the incident radiation can include any of alpha (α), beta (β), gamma (γ), X-ray and neutrons.

A method and system for calibrating a PET scanner are described. The PET scanner may have a field of view (FOV) and multiple detector rings. A detector ring may have multiple detector units. A line of response (LOR) connecting a first detector unit and a second detector unit of the PET scanner may be determined. The LOR may correlate to coincidence events resulting from annihilation of positrons emitted by a radiation source. A first time of flight (TOF) of the LOR may be calculated based on the coincidence events. The position of the radiation source may be determined. A second TOF of the LOR may be calculated based on the position of the radiation source. A time offset may be calculated based on the first TOF and the second TOF. The first detector unit and the second detector unit may be calibrated based on the time offset.