The present invention provides methods and systems for 3D imaging of in vivo and ex vivo tissues. The disclosed systems and methods employ an autoradiographic approach where particles emitted by a radioactive composition within the tissue are detected. Once detected, a 3D representation of the source of particles within the tissue is reconstructed for viewing and analysis.

The present invention provides methods and systems for 3D imaging of in vivo and ex vivo tissues. The disclosed systems and methods employ an autoradiographic approach where particles emitted by a radioactive composition within the tissue are detected. Once detected, a 3D representation of the source of particles within the tissue is reconstructed for viewing and analysis.

Disclosed is a proton beam detection device comprising a sensor having optical fiber of an arrangement structure capable of accurately and efficiently detecting proton dose distribution such as bragg peak, spread out bragg peak (SOBP) and symmetry of a therapeutic proton beam emitted in a scattering mode. The proton beam detection device, which detects a proton beam emitted from a proton beam source in a scattering mode, comprises a sensor having a plurality of detection modules including reference optical fiber and detection optical fiber having a length longer than the length of the reference optical fiber, the plurality of detection modules being diagonally arranged in the depth direction along which the proton beam emitted from the proton beam source proceeds.

Disclosed is a proton beam detection device comprising a sensor having optical fiber of an arrangement structure capable of accurately and efficiently detecting proton dose distribution such as bragg peak, spread out bragg peak (SOBP) and symmetry of a therapeutic proton beam emitted in a scattering mode. The proton beam detection device, which detects a proton beam emitted from a proton beam source in a scattering mode, comprises a sensor having a plurality of detection modules including reference optical fiber and detection optical fiber having a length longer than the length of the reference optical fiber, the plurality of detection modules being diagonally arranged in the depth direction along which the proton beam emitted from the proton beam source proceeds.

The present invention provides methods and systems for 3D imaging of in vivo and ex vivo tissues. The disclosed systems and methods employ an autoradiographic approach where particles emitted by a radioactive composition within the tissue are detected. Once detected, a 3D representation of the source of particles within the tissue is reconstructed for viewing and analysis.

The present invention provides methods and systems for 3D imaging of in vivo and ex vivo tissues. The disclosed systems and methods employ an autoradiographic approach where particles emitted by a radioactive composition within the tissue are detected. Once detected, a 3D representation of the source of particles within the tissue is reconstructed for viewing and analysis.

The present invention provides methods and systems for 3D imaging of in vivo and ex vivo tissues. The disclosed systems and methods employ an autoradiographic approach where particles emitted by a radioactive composition within the tissue are detected. Once detected, a 3D representation of the source of particles within the tissue is reconstructed for viewing and analysis.

Methods for discriminating among x-ray beams of distinct energy content. A first volume of scintillation medium converts energy of incident penetrating radiation into scintillation light which is extracted from a scintillation light extraction region by a plurality of optical waveguides that convert the scintillation light to light of a longer wavelength. An x-ray beam initially incident upon the first volume of scintillation medium and traversing the first volume is then incident on a second volume of scintillation medium. The first and second scintillation media may be separated by an absorber or one or more further volumes of scintillation medium, and may also have differential spectral sensitivities. Scintillation light from the first and second scintillation volumes is detected in respective detectors and processed to yield a measure of respective low energy and high-energy components of the incident x-ray beam.

The disclosed device for detecting the position and dose distribution of a therapeutic proton beam emitted in a pencil beam scanning mode comprises: a proton beam progressing position detection unit comprising a plurality of first optical fibers arranged along the first direction and a plurality of second optical fibers arranged along the second direction which is different from the first direction; and a proton beam dose distribution detection unit comprising a plurality of optical wavelength converter, each of which comprises an optical wavelength conversion disk and an optical wavelength-converting optical fibers arranged along the outer circumference of the optical wavelength conversion disk. The proton beam progressing position detection unit detects a proton beam progressing position through the arrangement of the first and second optical fibers, and the proton beam dose distribution detection unit detects a dose distribution of the proton beam progressing direction through a plurality of optical wavelength conversion disks.

The disclosed device for detecting the position and dose distribution of a therapeutic proton beam emitted in a pencil beam scanning mode comprises: a proton beam progressing position detection unit comprising a plurality of first optical fibers arranged along the first direction and a plurality of second optical fibers arranged along the second direction which is different from the first direction; and a proton beam dose distribution detection unit comprising a plurality of optical wavelength converter, each of which comprises an optical wavelength conversion disk and an optical wavelength-converting optical fibers arranged along the outer circumference of the optical wavelength conversion disk. The proton beam progressing position detection unit detects a proton beam progressing position through the arrangement of the first and second optical fibers, and the proton beam dose distribution detection unit detects a dose distribution of the proton beam progressing direction through a plurality of optical wavelength conversion disks.