The present invention provides a graphene grid that can suppress or prevent uneven distribution, uneven orientation, and the like of a structural analysis target substance, and can capture the structural analysis target substance with high efficiency and analyze the structural analysis target substance with high resolution, in a structural analysis by cryo-electron microscopy. A graphene grid of the present invention has a graphene surface into which a functional group is introduced.

The present invention provides a graphene grid that can suppress or prevent uneven distribution, uneven orientation, and the like of a structural analysis target substance, and can capture the structural analysis target substance with high efficiency and analyze the structural analysis target substance with high resolution, in a structural analysis by cryo-electron microscopy. A graphene grid of the present invention has a graphene surface into which a functional group is introduced.

The present invention is related to high-content microscopy imaging of microfluidic cell culture systems. A method of high-content microfluidic device microscopy is contemplated. along with related statistical analysis and microfluidic device adaptors.

Embodiments of the present disclosure provide an image processing method based on artificial intelligence (AI) and an image processing system. The method includes: obtaining a feature recognition result of an image by performing image processing on the image to recognize a feature of the image and the image being obtained by performing image acquisition on a section of a patient using a digital slide scanner to generate a whole slide image (WSI) as the image; determining an imaging area of the section within a field of view of an eyepiece of a microscope with which real-time imaging is performed on the section; determining, within the image, an image area corresponding to the imaging area of the section and acquiring, from the feature recognition result of the image, a target feature recognition result of the image area; and superimposing the target feature recognition result on the imaging area of the section.

Embodiments of the present disclosure provide an image processing method based on artificial intelligence (AI) and an image processing system. The method includes: obtaining a feature recognition result of an image by performing image processing on the image to recognize a feature of the image and the image being obtained by performing image acquisition on a section of a patient using a digital slide scanner to generate a whole slide image (WSI) as the image; determining an imaging area of the section within a field of view of an eyepiece of a microscope with which real-time imaging is performed on the section; determining, within the image, an image area corresponding to the imaging area of the section and acquiring, from the feature recognition result of the image, a target feature recognition result of the image area; and superimposing the target feature recognition result on the imaging area of the section.

It is an object to provide a cover slip sticking device capable of improving matching between types of clearing agents and cover slips. As a means for solving the problem, a cover slip sticking device includes a dipping bath (21) in which slide glasses (22) on which specimens are attached are housed to be dipped in a clearing agent, a holder (11) having a cover slip (10) and cover slip information (14), a mounting part (C) on which the holder is mounted, a sticking part (B) sticking the cover slip (10) taken out from the holder (11) on the slide glass (22), a reading unit (62) reading the cover slip information (14), a storage unit (65) storing a type of the clearing agent and matching information between types of clearing agents and types of cover slips and a determination unit (66) comparing the cover slip information (14) read by the reading unit (62) and the type of the clearing agent stored in the storage unit (65) with the matching information to determine whether the types match with each other or not.

It is an object to provide a cover slip sticking device capable of improving matching between types of clearing agents and cover slips. As a means for solving the problem, a cover slip sticking device includes a dipping bath (21) in which slide glasses (22) on which specimens are attached are housed to be dipped in a clearing agent, a holder (11) having a cover slip (10) and cover slip information (14), a mounting part (C) on which the holder is mounted, a sticking part (B) sticking the cover slip (10) taken out from the holder (11) on the slide glass (22), a reading unit (62) reading the cover slip information (14), a storage unit (65) storing a type of the clearing agent and matching information between types of clearing agents and types of cover slips and a determination unit (66) comparing the cover slip information (14) read by the reading unit (62) and the type of the clearing agent stored in the storage unit (65) with the matching information to determine whether the types match with each other or not.

A sample observation device includes: an emission optical system that emits planar light to a sample on an XZ plane; a scanning unit that scans the sample in a Y-axis direction so as to pass through an emission surface of the planar light; an imaging optical system that has an observation axis inclined with respect to the emission surface and forms an image of observation light generated in the sample; an image acquisition unit that acquires a plurality of pieces of XZ image data corresponding to an optical image of the observation light; and an image generation unit that generates XY image data based on the plurality of pieces of XZ image data. The image generation unit extracts an analysis region of the plurality of pieces of XZ image data acquired in the Y-axis direction, integrates brightness values of at least the analysis region in a Z-axis direction to generate X image data, and combines the X image data in the Y-axis direction to generate the XY image data.

Disclosed herein are device and method for performing a total internal reflection scattering (TIRS) measurement to a sample slide. The device comprises a first reflective plate having a first opening; a second reflective plate having second and third openings and disposed on top of the first reflective plate thereby forming a slot therebetween for accommodating the sample slide, wherein the first opening of the first reflective plate is disposed directly underneath the second opening of the second reflective plate; a white light source disposed in the space formed by the third opening of the second reflective plate and configured to emit a white light into the slot; and a first blackout layer disposed on top of the third opening thereby covering the white light source and keeping the emitted white light from leaking. When the sample slide is inserted into the slot, the white light source illuminates the sample slide so as to achieve the TIRS measurement to the sample slide.

Disclosed herein are device and method for performing a total internal reflection scattering (TIRS) measurement to a sample slide. The device comprises a first reflective plate having a first opening; a second reflective plate having second and third openings and disposed on top of the first reflective plate thereby forming a slot therebetween for accommodating the sample slide, wherein the first opening of the first reflective plate is disposed directly underneath the second opening of the second reflective plate; a white light source disposed in the space formed by the third opening of the second reflective plate and configured to emit a white light into the slot; and a first blackout layer disposed on top of the third opening thereby covering the white light source and keeping the emitted white light from leaking. When the sample slide is inserted into the slot, the white light source illuminates the sample slide so as to achieve the TIRS measurement to the sample slide.