The present disclosure provides a system for handling slides. The system includes a carrier having a linear engagement feature and a notch, a cartridge having a compartment configured to accept the carrier, and a cartridge positioning system with a platform configured to accept the cartridge and an actuator. The actuator has a rotary engagement feature configured to engage the linear engagement feature and a tab configured to interact with the notch when the carrier is accepted into the compartment and the cartridge is accepted onto the platform.

A slide handling system is disclosed. The system has a carrier comprising a retention hole, a compartment configured to accept the carrier, and a spacer disposed so as to engage the retention hole when the carrier is fully seated in the compartment.

A slide handling system is disclosed. The system has a carrier comprising a retention hole, a compartment configured to accept the carrier, and a spacer disposed so as to engage the retention hole when the carrier is fully seated in the compartment.

A biological reaction apparatus for receiving at least one substrate having a sample located in a sample region, and a separate cover, such that a reaction chamber is formed between the cover and substrate over the sample region, wherein the apparatus includes a locating means to locate the substrate; a cover locating means for locating and moving the cover with respect to the substrate; a fluid dispensing means for dispensing fluid into the reaction chamber; and a draining mechanism; wherein the draining mechanism includes wicking means.

A biological reaction apparatus for receiving at least one substrate having a sample located in a sample region, and a separate cover, such that a reaction chamber is formed between the cover and substrate over the sample region, wherein the apparatus includes a locating means to locate the substrate; a cover locating means for locating and moving the cover with respect to the substrate; a fluid dispensing means for dispensing fluid into the reaction chamber; and a draining mechanism; wherein the draining mechanism includes wicking means.

This disclosure provides methods and devices for the label-free detection of target molecules of interest. The principles of the disclosure are particularly applicable to the detection of biological molecules (e.g., DNA, RNA, and protein) using standard SiO2-based microarray technology.

This disclosure provides methods and devices for the label-free detection of target molecules of interest. The principles of the disclosure are particularly applicable to the detection of biological molecules (e.g., DNA, RNA, and protein) using standard SiO2-based microarray technology.

A microscope module for imaging a sample includes at least one illumination objective for producing an illumination beam along an illumination beam path arranged to illuminate lower surfaces of the sample and at least one detection objective having a detection path. The detection path is at an angle to the illumination beam path.

A microscope module for imaging a sample includes at least one illumination objective for producing an illumination beam along an illumination beam path arranged to illuminate lower surfaces of the sample and at least one detection objective having a detection path. The detection path is at an angle to the illumination beam path.

Optical systems and apparatuses configured for enabling substantially simultaneous observation of a plurality of points in an array from a common reference point. Without the optical systems and apparatuses disclosed herein, less than all of the plurality of points can be observed substantially simultaneously from the common reference point.