A climate controller having a control unit operable to activate and de-activate an HVAC unit, a temperature sensor and a humidity sensor operable to communicate temperature and relative humidity measurements to the control unit, and an interface to a network through which the control unit is operable to connect to a networked server and transmitting measurements for temperature and relative humidity; the control unit operable to activate and de-activate the HVAC unit according to the control unit operable to measure a temperature and humidity level, operable to obtain a value for a temperature setting and mode of operation for the HVAC unit, and operable to communicate a signal to the HVAC unit to effect the activation or de-activation. Climate control is achieved with reference to a comfort level temperature, and energy efficiency is achieved through the application of machine learning methods operated on data sets gathered by the climate controller.

A climate controller having a control unit operable to activate and de-activate an HVAC unit, a temperature sensor and a humidity sensor operable to communicate temperature and relative humidity measurements to the control unit, and an interface to a network through which the control unit is operable to connect to a networked server and transmitting measurements for temperature and relative humidity; the control unit operable to activate and de-activate the HVAC unit according to the control unit operable to measure a temperature and humidity level, operable to obtain a value for a temperature setting and mode of operation for the HVAC unit, and operable to communicate a signal to the HVAC unit to effect the activation or de-activation. Climate control is achieved with reference to a comfort level temperature, and energy efficiency is achieved through the application of machine learning methods operated on data sets gathered by the climate controller.

The present invention provides methods of amplifying a target nucleic acid utilizing a clamp oligonucleotide comprising a first target-binding region on the 3′-terminus and a second target-binding region on the 5′-terminus and tether region in between. The tether region may comprise a variety of user-defined sequences or elements that allow for further manipulation of the target nucleic acid. Such as, for example, capture followed by amplification, identification and/or sequencing. The target-binding regions bind to the target nucleic acid, the 3′-terminus functions as a primer to initiate extension across the target nucleic acid sequence and ligation of the gap results in formation of a circularized nucleic acid. This circular template can be used in a variety of processes, including amplification and sequencing.

The present invention provides methods of amplifying a target nucleic acid utilizing a clamp oligonucleotide comprising a first target-binding region on the 3′-terminus and a second target-binding region on the 5′-terminus and tether region in between. The tether region may comprise a variety of user-defined sequences or elements that allow for further manipulation of the target nucleic acid. Such as, for example, capture followed by amplification, identification and/or sequencing. The target-binding regions bind to the target nucleic acid, the 3′-terminus functions as a primer to initiate extension across the target nucleic acid sequence and ligation of the gap results in formation of a circularized nucleic acid. This circular template can be used in a variety of processes, including amplification and sequencing.

The purpose of the invention to provide a method for determining a lifting angle of a charge inside a grinding mill at a specific point in time and a method for positioning a grinding mill which is more accurate. Method for determining a lifting angle of a charge inside a mill body of a grinding mill being rotatable through a drive train, the method comprises the following steps of rotating the mill body; determining a reference lifting angle and a corresponding reference driving torque of the drive train at a reference point in time; calculating a fill factor for the reference point in time based on the reference lifting angle and the reference driving torque; determining a driving torque of the drive train; and calculating the lifting angle based on the driving torque and the fill factor.

The purpose of the invention to provide a method for determining a lifting angle of a charge inside a grinding mill at a specific point in time and a method for positioning a grinding mill which is more accurate. Method for determining a lifting angle of a charge inside a mill body of a grinding mill being rotatable through a drive train, the method comprises the following steps of rotating the mill body; determining a reference lifting angle and a corresponding reference driving torque of the drive train at a reference point in time; calculating a fill factor for the reference point in time based on the reference lifting angle and the reference driving torque; determining a driving torque of the drive train; and calculating the lifting angle based on the driving torque and the fill factor.

A climate control unit configured to control a heating unit and a cooling unit. The climate control unit includes a temperature sensor configured to measure a current dry bulb temperature, a humidity sensor configured to measure a current relative humidity, a processor, and a storage medium operably coupled to the processor. The storage medium has software instructions stored therein, which, when executed by the processor, cause the processor to determine a current apparent temperature based on the current dry bulb temperature and the current relative humidity, receive a user-selected desired apparent temperature, activate a heating mode when the current apparent temperature is below a lower apparent temperature threshold, and activate a cooling mode when the current apparent temperature is above an upper apparent temperature threshold. The software instructions, when executed by the processor, cause the processor to automatically switch between the heating mode and the cooling mode.

A climate control unit configured to control a heating unit and a cooling unit. The climate control unit includes a temperature sensor configured to measure a current dry bulb temperature, a humidity sensor configured to measure a current relative humidity, a processor, and a storage medium operably coupled to the processor. The storage medium has software instructions stored therein, which, when executed by the processor, cause the processor to determine a current apparent temperature based on the current dry bulb temperature and the current relative humidity, receive a user-selected desired apparent temperature, activate a heating mode when the current apparent temperature is below a lower apparent temperature threshold, and activate a cooling mode when the current apparent temperature is above an upper apparent temperature threshold. The software instructions, when executed by the processor, cause the processor to automatically switch between the heating mode and the cooling mode.

A digital scale for optimizing coffee brewing, and pour-over brewing in particular, is provided. Specifically, the present disclosure relates to a scale configured to determine the target amount of water to add based on any amount of coffee grounds used, compare an actual pour rate to a target pour rate when adding the target amount of water over a specific target pour time, and clearly communicate the same to the user.

A climate controller for a media library having a library interior includes one or more of a temperature sensor, a temperature controller, a humidity sensor, and a humidity controller. The temperature sensor senses an inside temperature within the library interior. The temperature controller is positioned within the library interior. The temperature controller controls the temperature within the library interior based at least partially upon the temperature information. The temperature controller can include one of a temperature increaser and a temperature decreaser. The humidity sensor senses an inside humidity within the library interior and generates humidity information. The humidity controller is positioned within the library interior. The humidity controller controls the humidity within the library interior based at least partially upon the humidity information. In various embodiments, the humidity controller cooperates with the temperature controller to control climate conditions within the library interior based on climate conditions outside of the library interior.