Genetic factors that regulate uterine development, endometrial function, and gonadotropin signaling are associated with increased time to conception. Newly discovered loci are shown to have a highly significant correlation with the phenotype. These newly discovered associations form the basis for methods of diagnosing and treating infertility. These loci are useful alone or in combination with other biomarkers and phenotypic markers to diagnose or assess the risk of an increased time to conception phenotype, and can help guide diagnosis and treatment while improving outcomes.

Genetic factors that regulate uterine development, endometrial function, and gonadotropin signaling are associated with increased time to conception. Newly discovered loci are shown to have a highly significant correlation with the phenotype. These newly discovered associations form the basis for methods of diagnosing and treating infertility. These loci are useful alone or in combination with other biomarkers and phenotypic markers to diagnose or assess the risk of an increased time to conception phenotype, and can help guide diagnosis and treatment while improving outcomes.

Disclosed is a method comprising extracting a gene sequence of a first gene from a first database in response to receiving a user's input, generating segmented sequences on the basis of the reverse complementary sequence of the gene sequence of the first gene, identifying, based on comparison of the segmented sequences with gene sequences of a second database, at least one matched sequence corresponding to at least one segmented sequence of the segmented sequences.

Disclosed is a method comprising extracting a gene sequence of a first gene from a first database in response to receiving a user's input, generating segmented sequences on the basis of the reverse complementary sequence of the gene sequence of the first gene, identifying, based on comparison of the segmented sequences with gene sequences of a second database, at least one matched sequence corresponding to at least one segmented sequence of the segmented sequences.

Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. These have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy of polynucleotide sequencing applications.

Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. These have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy of polynucleotide sequencing applications.

Provided herein are devices and methods suitable for sequencing, detecting, amplifying, analyzing, and performing sample preparation procedures for nucleic acids and other molecules. In some cases, the devices and methods provided herein are used for computation.

The present invention includes methods and kits for measuring a level of four or more biomarkers selected from IL1, IL7, TNF, IL5, IL6, CRP, IL10, TNC, ICAM1, FVII, I309, TNFR1, A2M, TARC, adiponectin, MIP1, eotaxin3, sVCAM1, TPO, FABP, IL18, B2M, SAA, PPY, DJ1, -synuclein, Ab40, Ab42, tau, alpha-syn, and NfL in a sample separated from a human subject in the primary care setting with neurological disease with a nucleic acid, an immunoassay or an enzymatic activity assay.

The present disclosure provides systems, methods, nucleic acids, and kits for barcoding and tracking cells based on CRISPR editing technologies.

The present disclosure provides systems, methods, nucleic acids, and kits for barcoding and tracking cells based on CRISPR editing technologies.