A method and system for developing a predictive model for diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in a human are disclosed. The method comprises receiving immune system data for each member of a population comprising healthy humans and humans with ME/CFS; extracting a set of features from the immune system data; and training a machine learning algorithm using the set of features to classify a human as healthy or having ME/CFS to obtain a predictive model. The system comprises a processor; and a memory storing computer executable instructions, which when executed by the processor cause the processor to perform operations of said method.

A method and system for developing a predictive model for diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in a human are disclosed. The method comprises receiving immune system data for each member of a population comprising healthy humans and humans with ME/CFS; extracting a set of features from the immune system data; and training a machine learning algorithm using the set of features to classify a human as healthy or having ME/CFS to obtain a predictive model. The system comprises a processor; and a memory storing computer executable instructions, which when executed by the processor cause the processor to perform operations of said method.

Disclosed herein is a system for predicting a loss of the function of genetic variants. The system includes a loss of function (LoF) prediction unit for calculating a probability that a target genetic variant will cause a loss of function (LoF) in a target gene through logistic regression with respect to a first probability that the target gene will be intolerant of the loss of function and a second probability that the target genetic variant contained in the target gene will be intolerant.

The need for an accurate, early, and precise estimation of expected delivery date (EDD) for the pregnant subject is vital. A system and method for predicting a day/date of delivery for a pregnant subject using one or more microbiome samples collected from the pregnant subject is provided. The disclosure relates to applying machine learning techniques on the microbiome characterization data corresponding to the biological sample(s) collected from the pregnant subject. The method further comprises using the predicted EDD to suitably plan and take required medical treatment or precautions or medical advice for the pregnant subject to prevent any pregnancy and/or delivery related complications and to manage the delivery appropriately. The disclosure also provides compositions of the microbiome data which can potentially influence the delivery date, or the method provides exemplary compositions of the microbiome data which plays vital role in estimating the EDD of the pregnant subject.

The need for an accurate, early, and precise estimation of expected delivery date (EDD) for the pregnant subject is vital. A system and method for predicting a day/date of delivery for a pregnant subject using one or more microbiome samples collected from the pregnant subject is provided. The disclosure relates to applying machine learning techniques on the microbiome characterization data corresponding to the biological sample(s) collected from the pregnant subject. The method further comprises using the predicted EDD to suitably plan and take required medical treatment or precautions or medical advice for the pregnant subject to prevent any pregnancy and/or delivery related complications and to manage the delivery appropriately. The disclosure also provides compositions of the microbiome data which can potentially influence the delivery date, or the method provides exemplary compositions of the microbiome data which plays vital role in estimating the EDD of the pregnant subject.

Embodiments of the present invention provide methods, computer program products, and systems for classification and identification of cancer genes while correcting for sample bias for tumor-derived genomic features as well as other biased features using machine learning techniques. Embodiments of the present invention can be used to receive a set of genes that include a first gene and a subset of synthetic genes that include similar features to the first gene and receive a set of gene labels associated with physiological characteristics. Embodiments of the present invention can estimate probabilities that genes in the set of genes are associated with gene labels in the set of gene labels using a machine learning classifier and estimate an effective probability range for the first gene and each gene label based, at least in part, on the first gene's estimated probabilities and the estimated probabilities of one or more of the synthetic genes.

Embodiments of the present invention provide methods, computer program products, and systems for classification and identification of cancer genes while correcting for sample bias for tumor-derived genomic features as well as other biased features using machine learning techniques. Embodiments of the present invention can be used to receive a set of genes that include a first gene and a subset of synthetic genes that include similar features to the first gene and receive a set of gene labels associated with physiological characteristics. Embodiments of the present invention can estimate probabilities that genes in the set of genes are associated with gene labels in the set of gene labels using a machine learning classifier and estimate an effective probability range for the first gene and each gene label based, at least in part, on the first gene's estimated probabilities and the estimated probabilities of one or more of the synthetic genes.

An embodiment of a method 100 for predicting a future state of a biological system is provided. The method 100 comprises receiving 101a microscope image depicting the biological system at an associated time and receiving 102 metadata corresponding to the microscope image. The method 100 further comprises extracting 103 features from the microscope image having information on a state of the biological system and using 104 the features and the metadata to predict the future state of the biological system.

An embodiment of a method 100 for predicting a future state of a biological system is provided. The method 100 comprises receiving 101a microscope image depicting the biological system at an associated time and receiving 102 metadata corresponding to the microscope image. The method 100 further comprises extracting 103 features from the microscope image having information on a state of the biological system and using 104 the features and the metadata to predict the future state of the biological system.

A system or method for detecting an immune system activation state in a patient can include a sample preparation system configured to isolate white blood cells from a sample of the patient, a cytometry module configured to determine biophysical properties of the white blood cells of the sample, and an analysis module configured to analyze the biophysical properties.