A method and system for obtaining and controlling genetic identification information are disclosed. The method includes providing personal information of a registrant to a secure website using an electronic communication device, taking a genetic material-containing sample from the registrant, providing the sample to a genetic material analysis facility, analyzing short tandem repeat (STR) regions of the genetic material at a plurality of loci to produce a genetic identity for the registrant, recording the personal information and the genetic identity in a blockchain ledger, and enabling the registrant to display on another electronic communication device a code corresponding to the genetic identity. The system includes a genetic material sampling kit, a short tandem repeat (STR) analysis kit, and electronic communication device(s) configured to enter the registrant's personal information, record the personal information and the genetic identity in the blockchain ledger, and display a code corresponding to the genetic identity.

This application provides a biological sequence data processing method including selecting a target base from bases in a biological sequence fastq file according to characteristic information of each base. A base patch file is generated by using characteristic information of the target base. Lossless compression is performed on the biological sequence fastq file to obtain a compressed fastq file, and lossless compression is performed on the base patch file to obtain a compressed patch file. The compressed patch file and the compressed fastq file are decompressed. In response to determining that characteristic information of the target base in the decompressed compressed patch file is inconsistent with characteristic information of the target base in the decompressed compressed fastq file, the characteristic information of the target base in the decompressed compressed fastq file is modified to the characteristic information of the target base in the decompressed compressed patch file.

This application provides a biological sequence data processing method including selecting a target base from bases in a biological sequence fastq file according to characteristic information of each base. A base patch file is generated by using characteristic information of the target base. Lossless compression is performed on the biological sequence fastq file to obtain a compressed fastq file, and lossless compression is performed on the base patch file to obtain a compressed patch file. The compressed patch file and the compressed fastq file are decompressed. In response to determining that characteristic information of the target base in the decompressed compressed patch file is inconsistent with characteristic information of the target base in the decompressed compressed fastq file, the characteristic information of the target base in the decompressed compressed fastq file is modified to the characteristic information of the target base in the decompressed compressed patch file.

Techniques for securely encoding, communicating, and comparing genomic information using probabilistic data structures are provided. In some embodiments, genomic information in a secure computing environment may be encoded and/or anonymized by building a probabilistic data structure that represents sub-strings of the genomic information as members of a set; the probabilistic data structure may then be securely transmitted outside the secure computing environment. In some embodiments, a probabilistic data structure representing sub-strings of sensitive genomic information as members of a set may be received in an unsecure computing environment and may be queried to generate output data indicating whether reference sub-strings are probable members of the set. In some embodiments, querying the probabilistic data structure, and other techniques of analyzing the probabilistic data structure, may be used to determine whether the sensitive genomic information corresponds to an organism associated with the reference genomic information.

Techniques for securely encoding, communicating, and comparing genomic information using probabilistic data structures are provided. In some embodiments, genomic information in a secure computing environment may be encoded and/or anonymized by building a probabilistic data structure that represents sub-strings of the genomic information as members of a set; the probabilistic data structure may then be securely transmitted outside the secure computing environment. In some embodiments, a probabilistic data structure representing sub-strings of sensitive genomic information as members of a set may be received in an unsecure computing environment and may be queried to generate output data indicating whether reference sub-strings are probable members of the set. In some embodiments, querying the probabilistic data structure, and other techniques of analyzing the probabilistic data structure, may be used to determine whether the sensitive genomic information corresponds to an organism associated with the reference genomic information.

Authentication tokens, systems, and methods are described. An illustrative method is disclosed to include receiving an electronic file including a digital image, receiving biometric information that is associated with a person, modifying the electronic file with the biometric information such that one or more pixels in the digital image are replaced with the biometric information, and storing the modified electronic file as a digital authentication token to be used in connection with authorized publications of original digital work.

Authentication tokens, systems, and methods are described. An illustrative method is disclosed to include receiving an electronic file including a digital image, receiving biometric information that is associated with a person, modifying the electronic file with the biometric information such that one or more pixels in the digital image are replaced with the biometric information, and storing the modified electronic file as a digital authentication token to be used in connection with authorized publications of original digital work.

In various embodiments, amplification-free DNA information methods, apparatus and systems are disclosed. A method of amplification-free information storage and retrieval comprises encoding digital data such as binary into nucleotide sequence motifs using an encoding scheme, and synthesizing replicate DNA molecules using an amplification-free DNA writing process. The amplification-free process of decoding the information stored in the DNA comprises exposing at least one of the replicate DNA molecules to a molecular electronics sensor that generates distinguishable signals in a measured electrical parameter of the sensor, wherein the distinguishable signals correspond to the sequence motifs, providing decoding back to the digital data.

A fluorescent in-situ hybridization imaging system includes a flow cell to contain a sample, a fluorescence microscope, and a control system. The fluorescence microscope includes a variable frequency excitation light source to illuminate the sample, a plurality of emission bandpass filters on a filter wheel, an actuator to rotate the filter wheel, and a camera positioned to receive fluorescently emitted light from the sample. The control system is configured to cause the variable frequency excitation light source to emit a light beam having a selected wavelength, cause the actuator to rotate the filter wheel to position a selected filter in a light path between the sample and the camera, obtain an image from the camera, and coordinate the variable frequency excitation light source and filter wheel such that the selected filter has an emission bandpass associated with emission by the fluorescent probes when excited by the selected wavelength.

A fluorescent in-situ hybridization imaging system includes a flow cell to contain a sample, a fluorescence microscope, and a control system. The fluorescence microscope includes a variable frequency excitation light source to illuminate the sample, a plurality of emission bandpass filters on a filter wheel, an actuator to rotate the filter wheel, and a camera positioned to receive fluorescently emitted light from the sample. The control system is configured to cause the variable frequency excitation light source to emit a light beam having a selected wavelength, cause the actuator to rotate the filter wheel to position a selected filter in a light path between the sample and the camera, obtain an image from the camera, and coordinate the variable frequency excitation light source and filter wheel such that the selected filter has an emission bandpass associated with emission by the fluorescent probes when excited by the selected wavelength.