In some embodiments, systems and methods for storing and/or retrieving digital information in a nucleic acid library are provided. In some embodiments, an integrated system comprising a nucleic acid synthesis device, a nucleic acid sequencing device, a computing device, and a nucleic acid library is provided. In some embodiments, a write request that associates a value with a key is received by the system, the system synthesizes nucleic acid molecules associated with the request, and stores the nucleic acid molecules in the nucleic acid library. In some embodiments, a read request for a key is received by the system, and the system sequences nucleic acid molecules from the nucleic acid library that are associated with the key.

A method (100) comprising: receiving (120) a genomic dataset comprising genomic data of one or more of a plurality of fields or attributes of different data; generating (130) a protection metadata structure for the genomic dataset, comprising one or more of: (i) specifications for selective encryption of one or more data components and regions of genomic data in an annotation table; (ii) specifications for selective signing of one or more data components and regions of genomic data in the annotation table; (iii) user key information; and (iv) access control policy; compressing (140) the genomic data and the protection metadata structure using one or more compression algorithms to generate a compressed genomic dataset and compressed protection metadata structure; and storing (150) the compressed genomic dataset and the compressed protection metadata structure in a container data structure in memory.

A method (100) comprising: receiving (120) a genomic dataset comprising genomic data of one or more of a plurality of fields or attributes of different data; generating (130) a protection metadata structure for the genomic dataset, comprising one or more of: (i) specifications for selective encryption of one or more data components and regions of genomic data in an annotation table; (ii) specifications for selective signing of one or more data components and regions of genomic data in the annotation table; (iii) user key information; and (iv) access control policy; compressing (140) the genomic data and the protection metadata structure using one or more compression algorithms to generate a compressed genomic dataset and compressed protection metadata structure; and storing (150) the compressed genomic dataset and the compressed protection metadata structure in a container data structure in memory.

A computer implemented method and a system of encryption of genomic data of a biological sample are provided, that improve the security of genetic information obtained from a sample, while guaranteeing traceability and identity-vigilance throughout the analysis chain. The computer implemented method and system disclosed herein allows a high level of identity-vigilance, improved labelling and traceability and provide a high level of confidentiality of genomics data.

A computer implemented method and a system of encryption of genomic data of a biological sample are provided, that improve the security of genetic information obtained from a sample, while guaranteeing traceability and identity-vigilance throughout the analysis chain. The computer implemented method and system disclosed herein allows a high level of identity-vigilance, improved labelling and traceability and provide a high level of confidentiality of genomics data.

A method for storage of an item of information (210) is disclosed. The method comprises encoding bytes (720) in the item of information (210), and representing using a schema the encoded bytes by a DNA nucleotide to produce a DNA sequence (230). The DNA sequence (230) is broken into a plurality of overlapping DNA segments (240) and indexing information (250) added to the plurality of DNA segments. Finally, the plurality of DNA segments (240) is synthesized (790) and stored (795).

A method for storage of an item of information (210) is disclosed. The method comprises encoding bytes (720) in the item of information (210), and representing using a schema the encoded bytes by a DNA nucleotide to produce a DNA sequence (230). The DNA sequence (230) is broken into a plurality of overlapping DNA segments (240) and indexing information (250) added to the plurality of DNA segments. Finally, the plurality of DNA segments (240) is synthesized (790) and stored (795).

Provided herein are compositions, devices, systems and methods for the generation and use of secured biomolecule-based information for storage. Further described herein are compositions, devices, systems and methods for bioencryption or biodecryption of information. Conversion of a digital sequence to a nucleic based sequence includes a step of selection of one or more bioencryption methods.

Provided herein are compositions, devices, systems and methods for the generation and use of secured biomolecule-based information for storage. Further described herein are compositions, devices, systems and methods for bioencryption or biodecryption of information. Conversion of a digital sequence to a nucleic based sequence includes a step of selection of one or more bioencryption methods.

In a fluorescent in-situ hybridization imaging system performs, as nested loops, the following: (1) a valve sequentially couples a flow cell to a plurality of different reagent sources to expose the sample to a plurality of different reagents, (2) for each reagent of the plurality of different reagents, a motor sequentially positions the fluorescence microscope relative to sample at a plurality of different fields of view, (3) for each field of view of the plurality of different fields of view, a variable frequency excitation light source sequentially emits a plurality of different wavelengths, (4) for each wavelength of the plurality of different wavelengths, an actuator sequentially positions the fluorescence microscope relative to sample at a plurality of different vertical heights, and (5) for each vertical height of the plurality of different vertical heights, an image is obtained.