A sensing cell culture vessel having one or more sensors on or in the vessel is configured to collect readings of various parameters or characteristics of a cell culture located within the sensing cell culture vessel and transmit the readings. The sensing cell culture vessels may be accompanied by a sensing plate having means for reading the one or more sensors and transmitting the one or more sensors to a server hosting electronic lab notebook for analyzing and storage of the readings. Sensing plates may further be equipped with cameras for imaging cell cultures located in the sensing cell culture vessels and transmitting the images to the server hosting the electronic lab notebook for analyzing and storage of the images. Embodiments of the invention allow for the continuous and automatic monitoring of cell cultures.

A connected ecosystem for a laboratory environment comprises an electronic lab notebook, and instrumented biosafety cabinet, and one or more sensing vessels containing cell cultures. The electronic lab notebook interfaces with the instrumented biosafety cabinet to provide instructions, guidance, and monitoring of a user during the set up of the experimental protocol and to receive commands from the user via one of several input modalities. After the experimental protocol has been set up in the instrumented biosafety cabinet, cell cultures may be moved to an incubator where the connected ecosystem may provide automatic monitoring of the cultures. The automatic monitoring is provided by sensors integrated into cell culture vessels and supplemented by images of the cell cultures captured by a camera. The user may be informed of deviations from expected results detected based on the automatic monitoring.

A method for anomaly detection and diagnosis in a chromatography system including a sample handling unit, a chromatographic separation unit, and a detection unit is disclosed. The method can include performing, with the chromatography system, a chromatography analysis of a sample to obtain a chromatogram of the sample, the sample including a known quantity of a reference standard. The method can also include determining peak information corresponding to the reference standard in the chromatogram and determining whether the peak information conforms with an expected response of the chromatography system associated with the reference standard. If the peak information does not conform with the expected response, the method can include determining that there is an anomaly in the operation of the chromatography system and diagnosing a cause of the anomaly as relating to the operation of at least one the sample handling unit, the chromatographic separation unit, and the detection unit.

Described herein are devices and methods for continuous real time monitoring of kidney function. In various embodiments, a urine analysis device collects sensor data describing one or more properties of urine. The urine analysis device may be integrated with a catheter system to continuously generate sensor data in real time as the urine is collected by the catheter system. Sensor data collected by the urine analysis device may be analyzed by physicians to detect changes in a patients kidney function. If necessary, based on the sensor data, physicians may perform an intervention to improve a patients kidney function.

Described herein are devices and methods for continuous real time monitoring of kidney function. In various embodiments, a urine analysis device collects sensor data describing one or more properties of urine. The urine analysis device may be integrated with a catheter system to continuously generate sensor data in real time as the urine is collected by the catheter system. Sensor data collected by the urine analysis device may be analyzed by physicians to detect changes in a patients kidney function. If necessary, based on the sensor data, physicians may perform an intervention to improve a patients kidney function.

Techniques for generating an ontology based on biomarker information associated with persons to facilitate improving clinical predictions relating to medical conditions are presented. An ontology generator component (OGC) can extract clinical features associated with patients and their associated times from medical records or databases to develop clinical profiles associated with the patients and relating to a medical condition. OGC can develop an ontology relating to the medical condition, including progression and severity of biomarkers associated with the medical condition, based on the clinical profiles and domain knowledge information relating to the medical condition. OGC can determine global features relating to progression and severity associated with the medical condition based on the ontology. At a forecasting point, the global features can be extracted from the ontology and applied to a prediction model to enhance prediction of onset of, or progression of, the medical condition for a patient.

Techniques for generating an ontology based on biomarker information associated with persons to facilitate improving clinical predictions relating to medical conditions are presented. An ontology generator component (OGC) can extract clinical features associated with patients and their associated times from medical records or databases to develop clinical profiles associated with the patients and relating to a medical condition. OGC can develop an ontology relating to the medical condition, including progression and severity of biomarkers associated with the medical condition, based on the clinical profiles and domain knowledge information relating to the medical condition. OGC can determine global features relating to progression and severity associated with the medical condition based on the ontology. At a forecasting point, the global features can be extracted from the ontology and applied to a prediction model to enhance prediction of onset of, or progression of, the medical condition for a patient.

The present disclosure provides compositions and methods for acidic compositions for use in optimizing the genital microbiome of a user or sexual partners of that user. The compositions may comprise a prebiotic oligosaccharide, a metal co-factor, and an essential oil comprising bornyl acetate. The compositions support the genital microbiota and are useful for, for example, hydrating, lubricating, cleaning, and/or decreasing irritation or inflammation of the urogenital and/or anogenital region of a subject, and/or enhancing the beneficial genital microbiota of a subject. Such compositions are useful before, during, and/or after sexual and/or reproductive activity. Furthermore, the compositions may have minimal or beneficial effect on gametes.

The present disclosure provides compositions and methods for acidic compositions for use in optimizing the genital microbiome of a user or sexual partners of that user. The compositions may comprise a prebiotic oligosaccharide, a metal co-factor, and an essential oil comprising bornyl acetate. The compositions support the genital microbiota and are useful for, for example, hydrating, lubricating, cleaning, and/or decreasing irritation or inflammation of the urogenital and/or anogenital region of a subject, and/or enhancing the beneficial genital microbiota of a subject. Such compositions are useful before, during, and/or after sexual and/or reproductive activity. Furthermore, the compositions may have minimal or beneficial effect on gametes.

A method of creating a genetically personalized intravenous or intramuscular nutrition therapy treatment formula includes developing an initial mapping of individual micronutrients to SNPs, symptoms, conditions, and therapeutic objectives based on existing individual scientific literature references that link the specific micronutrient to an SNP, a symptom, a condition, or a therapeutic objective. The method includes receiving an SNP and a symptom, a condition, or a therapeutic objective for a patient, comparing the SNP, symptom, condition, therapeutic objective combination with the initial mapping to identify matching micronutrients, creating a custom treatment formula with the identified micronutrients, and treating the patient with the formula. Feedback data about the formula's effectiveness is received and the initial mapping is updated to account for the feedback data. This process is repeated for subsequent patients positioned geographically remotely from each other so that future patients are treated with reference to an updated current mapping.