A radioisotope generator including a laser, a volume of target isotope, and nanoparticles in a solid, liquid, or gas state is provided. In at least one aspect, the radioisotope generator accelerates the decay rate of an isotope, with the laser being used to accelerate the decay of the isotope for the production of desired product isotopes.

Technology is described to uniformly apply doses of radiation to a target material. An irradiation device may comprise an enclosure configured to receive a target material and a source configured to emit primary radiation within the enclosure. The primary radiation may be configured to irradiate at least a first portion of the target material. The irradiation device may further comprise a scattering medium disposed within the enclosure. The scattering medium may be configured to produce secondary radiation through scatter interactions in response to the primary radiation, the secondary radiation configured to irradiate at least a second portion of the target material. A thickness of the scattering medium relative to the primary radiation may have a thickness of at least 3 millimeters).

A system for producing technetium-99m from molybdate-100. The system comprises: a target capsule apparatus for housing a Mo-100-coated target plate; a target capsule pickup apparatus for engaging, and delivering the target cell apparatus into a target station apparatus; target station apparatus for receiving and mounting therein the target capsule apparatus. The target station apparatus is engaged with a cyclotron for irradiating the Mo-100-coated target plate with protons. The irradiated target capsule apparatus is transferred to a receiving cell apparatus comprising a dissolution/purification module for receiving therein a proton-irradiated Mo-100-coated target plate. A conveyance conduit infrastructure interconnects: (i) the target capsule pickup apparatus with the target station apparatus, (ii) the target station apparatus and the receiving cell apparatus; and (iii) the receiving cell apparatus and the dissolution/purification module.

A system for producing technetium-99m from molybdate-100. The system comprises: a target capsule apparatus for housing a Mo-100-coated target plate; a target capsule pickup apparatus for engaging, and delivering the target cell apparatus into a target station apparatus; target station apparatus for receiving and mounting therein the target capsule apparatus. The target station apparatus is engaged with a cyclotron for irradiating the Mo-100-coated target plate with protons. The irradiated target capsule apparatus is transferred to a receiving cell apparatus comprising a dissolution/purification module for receiving therein a proton-irradiated Mo-100-coated target plate. A conveyance conduit infrastructure interconnects: (i) the target capsule pickup apparatus with the target station apparatus, (ii) the target station apparatus and the receiving cell apparatus; and (iii) the receiving cell apparatus and the dissolution/purification module.

Technology is described to uniformly apply doses of radiation to a target material. An irradiation device may comprise an enclosure configured to receive a target material and a source configured to emit primary radiation within the enclosure. The primary radiation may be configured to irradiate at least a first portion of the target material. The irradiation device may further comprise a scattering medium disposed within the enclosure. The scattering medium may be configured to produce secondary radiation through scatter interactions in response to the primary radiation, the secondary radiation configured to irradiate at least a second portion of the target material. A thickness of the scattering medium relative to the primary radiation may have a thickness of at least 3 millimeters).

Technology is described to uniformly apply doses of radiation to a target material. An irradiation device may comprise an enclosure configured to receive a target material and a source configured to emit primary radiation within the enclosure. The primary radiation may be configured to irradiate at least a first portion of the target material. The irradiation device may further comprise a scattering medium disposed within the enclosure. The scattering medium may be configured to produce secondary radiation through scatter interactions in response to the primary radiation, the secondary radiation configured to irradiate at least a second portion of the target material. A thickness of the scattering medium relative to the primary radiation may have a thickness of at least 3 millimeters).

Systems and methods for determining a radiation isocenter of a linear accelerator (LINAC). Determining the radiation isocenter may include determining a set of three-dimensional (3D) radiation beam axes of the LINAC from two-dimensional (2D) radiation transmission images. The radiation isocenter may be determined based on at least the set of 3D radiation beam axes. Determining the set of 3D radiation beam axes may including constructing a 3D radiation beam axis based on a determined location of a beam axis of a radiation beam generated with a gantry of the LINAC at an angle relative to a reference gantry angle, a determined center of a shadow of a radiation opaque marker in the radiation field of the radiation beam, and the gantry angle.

Systems and methods for determining a radiation isocenter of a linear accelerator (LINAC). Determining the radiation isocenter may include determining a set of three-dimensional (3D) radiation beam axes of the LINAC from two-dimensional (2D) radiation transmission images. The radiation isocenter may be determined based on at least the set of 3D radiation beam axes. Determining the set of 3D radiation beam axes may including constructing a 3D radiation beam axis based on a determined location of a beam axis of a radiation beam generated with a gantry of the LINAC at an angle relative to a reference gantry angle, a determined center of a shadow of a radiation opaque marker in the radiation field of the radiation beam, and the gantry angle.

A carrier for an irradiated target includes a first portion and a second portion having inner walls. One or both of the first and second portions has a recess extending inwardly from the inner wall thereof to receive the irradiated target. The first and second portions are removably attachable in sealing engagement. The inner walls face each other and form a barrier around the recess upon the first and second portions being removably attached. A fastening system provided on one or both of the first and second portions maintains the first and second portions in sealing engagement. There is also disclosed a kit of the carrier and the irradiated target, a dissolution system for producing a solution from the irradiated target, and a corresponding method.

A carrier for an irradiated target includes a first portion and a second portion having inner walls. One or both of the first and second portions has a recess extending inwardly from the inner wall thereof to receive the irradiated target. The first and second portions are removably attachable in sealing engagement. The inner walls face each other and form a barrier around the recess upon the first and second portions being removably attached. A fastening system provided on one or both of the first and second portions maintains the first and second portions in sealing engagement. There is also disclosed a kit of the carrier and the irradiated target, a dissolution system for producing a solution from the irradiated target, and a corresponding method.