There is provided a speckle measurement apparatus to improve accuracy of flow velocity measurement or the like of particulates such as erythrocytes, the speckle measurement apparatus including an imager that captures scattered light images returned from an object to be measured when the object to be measured is irradiated with coherent light as speckle images, and a controller that determines a measurement area that is the same site of the object to be measured in a plurality of the speckle images captured continuously in time series by the imager by incorporating a displacement amount of a relative positional relationship between the object to be measured and the imager.

A system for use in monitoring blood circulation data of a user is disclosed. The system comprising a monitoring unit comprising at least one light source unit configured for providing and directing coherent illumination onto at least one selected inspection region on the user's body, and a collection unit configured for collecting light returning for at least a portion of the inspection region and generating a plurality of image data pieces associated with secondary speckle patterns in the collected light returning from said regions; and a control unit configured and operable for receiving said plurality of image data pieces, determining correlation functions between speckle patterns in consecutive image data pieces, processing said correlation functions for determining data indicative of at least two heart rate data sequence indicative of heart rate of the user, and determining data indicative of circulation pressure of the user in accordance with said data indicative of heart rate of the user measured at said first and second monitoring regions.

A system is described, for use in optical measurement of a sample. The system comprising: an illumination unit configured for providing coherent illumination of one or more selected wavelength ranges and directing it onto one or more selected inspection regions of the sample, a collection unit configured for collecting light returning from the inspection region and generating output data comprising a sequence of image data pieces indicative of secondary speckle patterns formed at an intermediate plane in optical path of light collection, a depth resolving module configured for affecting at least one of the illumination unit and the collection unit for determining an association between collected secondary speckle patterns and depth layers of the sample; and a control unit being connectable to said depth resolving module and configured for operating said depth resolving module and for receiving said sequence of image data pieces from the collection unit and processing said sequence of image data pieces by determining correlation functions between at least portions of said secondary speckle patterns associated with corresponding depth layers of the sample, thereby determining one or more parameter variations along depth of the sample.

Systems and methods are provided, which use at least two coherent light sources with known phase relations between them, which are configured to illuminate a target with at least two corresponding spots, an optical unit comprising a mask and configured to focus, onto a sensor, interfered scattered illumination from the spots of the target, passing through the mask, to yield a signal, at least one shifter configured to shift a frequency of at least one of the coherent light sources to provide a carrier frequency in the signal, and a processing unit configured to derive a vibration frequency of the target from the sensor signal with respect to the carrier frequency. The vibration frequency of the target is separated from the carrier frequency and speckle disturbances may be attenuated or avoided.

A low coherence imaging method comprises acquiring image data of an object with an interferometric imaging system, where the image data is from a location of the object at first and second times; determining a first depth profile from the image data from the location at the first time and a second depth profile from the image data of the location at the second time; determining a change with respect to depth between the first and second depth profiles; and determining a property, or identifying a location, of at least one dynamic particle in the object based on the change between the first and second depth profiles. The method is able to identify, analyze, and/or visualize dynamic particles with features comparable to at least fluorescein angiography, indocyanine green angiography, confocal scanning laser fluorescein angiography, confocal scanning laser indocyanine green angiography, and fluorescence microscopy images, without the use of a dye.

Disclosed herein are systems, methods, and devices for calibrating contrast measurements from laser speckle imaging systems to accurately determine unknown particle motion characteristics, such as flow rate. The calibration stores to memory calibration data, which may include a set of measurements from samples with known particle characteristics and/or estimates of noise, including the effects on contrast arising from undesired signals unrelated to the unknown particle motion characteristics. The calibration data may be accessed and used to correct an empirical measurement of contrast and/or interpolate a value of the unknown particle motion characteristic. The system may include a light source, photodetector, processor, and memory, which can be combined into a single device, such as a wearable device, for providing calibrated flow measurements. The device may be used, for example, to measure blood flow, cardiac output, and heart rate, and can be used to amplify the pulsatile signal.

Speckle contrast method and system that discriminates photons based on their path length in tissue, the method comprising the steps of: directing light from a pulsed light into a sample by optical elements; synchronizing the time between the pulse injection to sample and the detection unit; collecting the photons that have travelled through the sample by optics, and conveying the photons of a single or a limited number of speckles from the sample to one or more detection elements; time-tagging photons thanks to the synchronization of the detector element and/or the time-tagging electronics with the laser pulse emission; estimating each photon time-of-flight by the difference between its time tag and the laser pulse emission; categorizing the detected photons based on the value of the time-of-flight in a certain number of time gates; measuring the speckle contrast

A system and corresponding method are presented. the system comprises: an illumination unit comprising at least one light source configured for emitting coherent illumination of one or more selected wavelength ranges having selected illumination modulation pattern and for directing said illumination onto one or more selected inspection regions; and a collection unit comprising at least one detector array and imaging optical arrangement configured for collecting interacting light from the one or more selected inspection regions and for generating corresponding one or more sequences of image data pieces at selected sampling rate. The image data pieces being indicative of secondary speckle patterns formed in collected interacting light. The illumination modulation pattern is selected for increasing temporal bandwidth collection of speckle patterns associated with temporal shifts in said one or more inspection regions.

A system for monitoring glucose blood level of a user is disclosed. The system comprising an illumination unit configured for providing coherent optical illumination on a selected inspection region on the user body, a collection unit configured for collecting light returning from the inspection region and generating a plurality of image data pieces associated with speckle patterns in the collected light, and a control unit comprising a processing utility and storage utility comprising pre-stored calibration data, the processing utility is configured for receiving input data on a plurality of image data pieces from the collection unit and for processing said input data for determining correlation functions between different image data pieces and using said correlation functions and said pre-stored calibration data for determining data on glucose blood level of the user.

A system for use in monitoring parameters of an object is described. The system comprising an illumination unit configured for providing coherent illumination of a predetermined wavelength range and for directing said coherent illumination onto an inspection region of the object, and a collection unit comprising a lens arrangement and a detector array and configured for collecting light returning from the inspection region and for generating one or more image data pieces associated with speckle patterns generated at an intermediate plane between the inspection region and said detector array. The detector array is configured as a rolling shutter type detector unit and said collection unit comprises at least one light splitting element configured for splitting collected light to thereby form a plurality of image replications corresponding to said speckle patterns on said detector array.