Described herein is a spectrometer device for optical analysis of at least one sample. The spectrometer device includes: at least one housing having at least one entrance window; at least one wavelength-selective element configured for separating incident light into a spectrum of constituent wavelengths, the wavelength-selective element being disposed within the housing; at least one detector device configured for detecting at least a portion of the constituent wavelengths, the detector device being disposed within the housing; and at least one contact sensor device for detecting a contact of the spectrometer device with the sample, where the contact sensor device includes at least one optical contact sensor device, where the optical contact sensor device is configured to detect an influence of the presence of the sample onto the transmission of the optical signal.

An example system includes a light source, a first spectrometer, a second spectrometer, and an electronic control module. The light source is operable to emit light within a first range of wavelengths in a field of illumination. The first spectrometer is operable to measure first sample light reflected from an object within a second range of wavelengths and in a first field of detection. The second spectrometer is operable to measure second sample light reflected from the object within a third range of wavelengths and in a second field of detection. The electronic control module operable to determine, based on the measured first sample light and the measured second sample light, a distance between the system and the object, and determine, based on the measured first sample light and the measured second sample light, a spectral distribution of light corresponding to the object.

Systems and methods for characterizing biological specimens, which may involve identifying a cell type or state corresponding to a disease or health condition of a subject. A biological specimen is subjected to electromagnetic radiation for spectroscopic analysis such as Surface Enhanced Raman Spectroscopy (SERS) to determine the relative abundance of proteins or amino acids in the cells, which is used in a comparison to previously stored relative abundance data of a database to automatically identifies at least one of cell type and/or cell state of the cells (or the disease/health state of the subject with the disease state including the possibility of virus infection, or drug susceptibility of a subject to bacteria or fungus). The method may also be employed with biological entities or cellular structures such as exosomes and even protein or nucleic acid fragments to determine disease states or health states of the subject.

An electronic device and a method for spectral model explanation are provided. The method includes: obtaining first labeled spectral data; storing a plurality of pipelines, selecting a selected pipeline from the pipelines, and generating a first measurement result corresponding to the first labeled spectral data according to the selected pipeline; and determining an important wavelength range corresponding to the selected pipeline according to the first measurement result.

A system for performing spectroscopy, including a first frequency comb source outputting first electromagnetic radiation comprising a first frequency comb centered at a first wavelength and having a first repetition rate; a second frequency comb source outputting a second electromagnetic radiation comprising a second frequency comb centered at a second wavelength and having a second repetition rate; a nonlinear device positioned to receive the first frequency comb and the second frequency comb, wherein the nonlinear device interacts the first frequency comb and the second frequency comb through sum frequency generation or difference frequency generation so as to generate an output electromagnetic radiation; and a detection system outputting a signal in response to detecting an interference of the output electromagnetic radiation with a third electromagnetic radiation, the signal comprising information used for determining a spectrum of at least the first frequency comb or the second frequency comb.

A system for non-invasively interrogating an in vivo sample for measurement of analytes comprises a pulse sensor coupled to the in vivo sample for detect a blood pulse of the sample and for generating a corresponding pulse signal, a laser generator for generating a laser radiation having a wavelength, power and diameter, the laser radiation being directed toward the sample to elicit Raman signals, a laser controller adapted to activate the laser generator, a spectrometer situated to receive the Raman signals and to generate analyte spectral data; and a computing device coupled to the pulse sensor, laser controller and spectrometer which is adapted to correlate the spectral data with the pulse signal based on timing data received from the laser controller in order to isolate spectral components from analytes within the blood of the sample from spectral components from analytes arising from non-blood components of the sample.

A spectral device is provided with: a filter having a property of transmitting light of multiple wavelength ranges from a measurement object; a driving means to slide the filter; and a detector to detect an intensity of the light from the measurement object, the light having passed through the filter, the detector to further measure the intensity of the light multiple times sequentially while the driving means slides the filter and thereby obtain multiple pieces of measured data to be used for a calculation of spectral information.

An auxiliary device and system for traffic light detection and communication. The auxiliary device is positionable adjacent to a traffic light. The auxiliary device includes at least one light pipe positionable adjacent to at least one traffic indicator disposed on a surface of the traffic light. The at least one light pipe is capable of carrying a light output from the least one traffic indicator to the auxiliary device. The auxiliary device includes a sensor for sensing the light output, and a processor operatively connected for computer communication to the sensor. The processor receives a measurement from the sensor. The measurement is associated with the light output. The processor detects a state of the light output based on the measurement, and transmits the state to one or more remote vehicles.

A device may receive a master data set for a first spectroscopic model; receive a target data set for a target population associated with the first spectroscopic model to update the first spectroscopic model; generate a training data set that includes the master data set and first data from the target data set; generate a validation data set that includes second data from the target data set and not the master data set; generate, using cross-validation and using the training data set and the validation data set, a second spectroscopic model that is an update of the first spectroscopic model; and provide the second spectroscopic model.

An apparatus for analysis of a sample of a material is disclosed. The apparatus includes a holder configured to accept the sample. The holder includes a sample plate having a first surface configured to contact the accepted sample and a sample lens array that comprises a plurality of focusing elements.