Disclosed is an instrument including a multipath, monolithic optical component, made up of a portion of a transparent material between two opposite faces of the component. One of the two faces of the component is formed by a first refracting surface, and the other face includes several second refracting surfaces which are juxtaposed. Each optical path of the component is formed by one of the second refracting surfaces in combination with a corresponding portion of the first refracting surface. One such component is suited for being part, within the instrument, of a detection module with multiple optical paths arranged in parallel, with a matrix photodetector shared by the optical paths. Such a detection module may be compact enough in order to be integrated into a cryostat cold screen, improving cooling thereof, and may be combined with an objective in order to form an instrument with multiple optical paths.

An optical device may comprise an array of sensor elements that includes a plurality of pixels and a multispectral filter disposed on the array of sensor elements. The multispectral filter may be configured to pass a first transmission percentage of light of a particular spectral range to a first set of pixels of the plurality of pixels and pass a second transmission percentage of light of the particular spectral range to a second set of pixels of the plurality of pixels.

A chip-based planar Raman spectroscopic measurement system is disclosed comprising at least a semiconductor laser as excitation light source, an output waveguide coupling and delivering laser light out of chip, a photo-detector monitoring the laser optical power, an input waveguide coupling signal light to chip, a planar spectrometer comprising Planar Waveguide Grating (PWG) and an array photo-detectors, and control electronics. In some embodiments the PWG is a fixed frequency Arrayed Waveguide Grating (AWG), the laser is frequency-tunable. In other embodiments, the laser has fixed frequency, the PWG or the AWG is frequency tunable. In either case, the frequency tunability will ensure the recapture of the spectral information missed due to the spectral characteristics of the planar waveguide grating such as the channel spacing of the AWG, resulting in high channel count and high-resolution Raman measurement of sufficient spectral range.

Disclosed are a multi-channel array type optical sensing device and its manufacturing method, and the device includes an encapsulating housing and at least one electrical contact on a side of the encapsulating housing. The encapsulating housing includes a printed circuit board, a light receiving unit, and a filter array for receiving an external incident light and converting the external incident light into a multi-channel optical signal with a non-continuous wavelength. The light receiving unit is electrically connected to the printed circuit board for receiving the multi-channel optical signal. The printed circuit board is provided for transmitting the multi-channel optical signal to the outside through the at least one electrical contact. With a simple design, the multi-channel array type optical sensing device becomes an optical component with the features of low cost and easily extended application and suitable for the spectral analysis of various testing objects.

A method for measuring a property of radiation from different sources such as moving particles or different spatial locations on each particle includes providing a spatial modulator common to all of the sources having a sequence of configurations, each of which configurations causes the radiation flux to pass along paths to respective modulation ports and cycling the common spatial modulator past each of the modulation ports so that the sequence of configurations is applied to each modulation port. The sequence of configurations comprises an ordered array of optical elements on a substrate. In one embodiment, the modulator is arranged in a circle around an axis of rotation of a rotating singulation disk. At least one source is a reference source which has not interacted with the source to be analyzed and the sample and reference sources are compared.

The present invention discloses a multichannel broadband high-resolution spectrograph, comprising a plurality of light source incident slits, a multichannel integrated grating, a multichannel shared two-dimensional focus imaging mirror and a two-dimensional area array detector which are sequentially disposed along a light source incident or reflection line, wherein the multichannel integrated grating consists of a plurality of sub-gratings, incident light enters the corresponding integrated gratings along the light source incident slits and then is focused by the shared two-dimensional focus imaging mirror after diffraction of the integrated grating, and diffraction light in a full-spectrum region is incident onto a focal plane of the two-dimensional area array detector for detection. No any mechanical displacement part is disposed, multichannel, full-spectrum and high-speed detection and analysis is achieved, and the present disclosure has high spectrum resolution and working reliability.

A system includes first and second radiation sources, first and second detectors, a signal digitizer, a controller, and an analyzer. The first and second radiation sources generate respective first and second beams of radiation to irradiate a target. The first beam and second beams each include a first wavelength operated at a first modulation frequency and a second wavelength operated at a second modulation frequency. The first and second detectors each include a photo-sensitive element that generate first or second detection signals, a Faraday shielding enclosure, a signal amplifier, and a frequency mixer to frequency-adjust the first or second detection signals. The controller provides timing information to inform an activation scheme of the first and second radiation sources and corresponding radiation detection events at the first and second detectors. The analyzer analyzes the first and second detection signals and determines at least amplitude and phase information of the scattered radiation.

Provided are methods and systems for concurrent imaging at multiple wavelengths. In one aspect, a hyperspectral/multispectral imaging device includes a lens configured to receive light backscattered by an object, a plurality of photo-sensors, a plurality of bandpass filters covering respective photo-sensors, where each bandpass filter is configured to allow a different respective spectral band to pass through the filter, and a plurality of beam splitters in optical communication with the lens and the photo-sensors, where each beam splitter splits the light received by the lens into a plurality of optical paths, each path configured to direct light to a corresponding photo-sensor through the bandpass filter corresponding to the respective photo-sensor.

An integrated spectro-microscopic system for multimodality imaging on a sample includes a reflected differential interference contrast (RDIC) microscope, a Raman spectroscope optically coupled with the RDIC microscope and a total internal reflection fluorescence/scattering (TIRF/TIRS) microscope optically coupled with the RDIC microscope such that the integrated spectro-microscopic system is capable of simultaneously acquiring both the RDIC images, the Raman spectra and TIRF/TIRS images on the same sample.

An apparatus and associated methodology are provided to obtain intrinsic hyper-spectral data cubes such that the intrinsic spectrum associated with each pixel of the field of view does not contain irrelevant spectral components. This is accomplished by obtaining a focused spatial image of the field of view and a diffuse image of the field of view with a slit arrangement including a translucent material that allows imaging of a focused spatial image with its associated spectrum and a diffuse image of the illumination with its associated spectrum at essentially the same time. Unprocessed intrinsic data cubes are generated from the obtained spectrum which are processed with the intrinsic methodology of the invention to generate an intrinsic hyper-spectral data cube of the field of view.