An optical system includes a spectrograph having a concave diffraction grating and a detector. An aperture is selectively positioned by an associated actuator or positioning mechanism either into, or out of, an optical path of the input light beam downstream of a sample and prior to entering the spectrograph. A slit plate having a plurality of different size entrance slits is positioned downstream of the aperture and movable by an associated actuator or positioning mechanism to position one of the plurality of entrance slits in the optical path of the input light beam. A controller coupled to the detector and the actuators is configured to control the actuators to selectively position the aperture and the slit plate to provide a selectable resolution of the spectrograph. The aperture setting and slit plate setting may be determined from a lookup table in response to a request for finer or coarser spectral resolution.

An optical system includes a spectrograph having a concave diffraction grating and a detector. An aperture is selectively positioned by an associated actuator or positioning mechanism either into, or out of, an optical path of the input light beam downstream of a sample and prior to entering the spectrograph. A slit plate having a plurality of different size entrance slits is positioned downstream of the aperture and movable by an associated actuator or positioning mechanism to position one of the plurality of entrance slits in the optical path of the input light beam. A controller coupled to the detector and the actuators is configured to control the actuators to selectively position the aperture and the slit plate to provide a selectable resolution of the spectrograph. The aperture setting and slit plate setting may be determined from a lookup table in response to a request for finer or coarser spectral resolution.

An optical instrument for spectroscopy applications includes a compact arrangement having a three-dimensional folded optical path. A plate configured as an optical reference plane is secured to a housing and is configured to secure optical components above or below the plate. A modular light source module may be secured within the housing without fasteners. A monochromator and spectrometer are secured below the plate. Mirrors disposed above the plate are configured to direct light from the monochromator passing through a first opening in the plate through a sample disposed above the plate, and to direct light from the sample through a second opening in the plate to the spectrometer. A controller is configured for communication with the monochromator and the spectrometer. The controller may control an entrance slit actuator for the spectrometer and positioning of an aperture upstream of the spectrometer to adjust resolution and throughput.

The invention relates to a microscope for the molecular spectroscopic analysis of a sample (2), having a beam path having at least one quantum cascade laser (QCL) (3) which emits an infrared (IR) radiation, a phase modulator (5) which is arranged between the QCL (3) and the sample (2), at least one optical element (6) which is arranged between the phase modulator (5) and the sample (2) and a sensor (4) which detects an IR radiation which is transmitted and/or reflected by the sample (2). The invention relates further to a method for the molecular spectroscopic analysis of a sample (2) comprising the steps of irradiating the sample (2) with an infrared (IR) radiation by means of a quantum cascade laser (QCL) (3), wherein the IR radiation is directed onto the sample (2) via a phase modulator (5) and at least one optical element (6), and detecting the IR radiation which is reflected and/or transmitted by the sample (2).

The present disclosure relates to a method and related system for spectrum optimization of an illumination light source. Spectrum optimization according to the present disclosure can be based on various optimization parameters, including but not limited to luminous efficacy, color rendering effect, luminous efficacy of radiation, mesopic efficacy of radiation, cirtopic efficacy of radiation, etc. The present method and system are capable of optimizing illumination performance of a light source in various aspects in an individual or integrated manner. Further, the present method and system are capable of accommodating different illumination purposes and conditions by combining and prioritizing different optimization parameters.

The present disclosure relates to a method and related system for spectrum optimization of an illumination light source. Spectrum optimization according to the present disclosure can be based on various optimization parameters, including but not limited to luminous efficacy, color rendering effect, luminous efficacy of radiation, mesopic efficacy of radiation, cirtopic efficacy of radiation, etc. The present method and system are capable of optimizing illumination performance of a light source in various aspects in an individual or integrated manner. Further, the present method and system are capable of accommodating different illumination purposes and conditions by combining and prioritizing different optimization parameters.

Described herein is the use of a visible near infrared (VNIR) hyperspectral imaging system as a non-invasive diagnostic tool for early detection of Alzheimer's disease (AD). Also described herein is the use of a VNIR hyperspectral imaging system in high throughput screening of potential therapeutics against AD.

A system and device that measures a specimen's surface profile by passing a bright white light source through a series of lenses which generate repeatable chromatic focal shift variations of wavelengths of white light for Z axis measurements. The movement of the sensor along an X-Y raster pattern is controlled by a X-directional and Y-directional scanner used in combination with X and Y actuators. The system and device translate the chromatic focal shifts into digital data which may then be used to both control the position of the lenses along the surface of the specimen and generate a 3D topographical images of the specimens being profiled.

A lenslet based integral field spectrograph (IFS) may have a design that makes better use of the detector pixels by placing adjacent spectra next to each other rather than staggering the spectra. Such a design maintains the main compactness and simplicity of prior lenslet array based IFSs, but improves the detector efficiency, which is rather low in conventional lenslet array based IFSs.

Provided are an image data processing device and an image data processing method that can generate a high-quality image. An image data processing device for processing first image data obtained by imaging light of a subject, which has been spectrally separated into a plurality of wavelengths through a band-pass filter, with an image sensor includes a processor. The processor is configured to acquire the first image data, to calculate a feature amount in a transmission wavelength range of the band-pass filter on the basis of the first image data, and to calculate information of spectral characteristics of the subject on the basis of the feature amount.