There is provided an automated system for preparing tissue samples that comprises one or more microtomes, a hydration system, and a processor, the processor being programmed to initiate facing, by one or more microtomes, of a first tissue block comprising a first tissue sample embedded in an embedding material, and cause the first tissue block to be hydrated by the hydration system for a first predetermined time, and initiate facing, by one or more microtomes, of a second tissue block while the first tissue block is being hydrated, the second tissue block comprising a second tissue sample embedded in an embedding material, and cause the second tissue block to be hydrated by the hydration system for a second predetermined time, and to initiate the one or more microtomes to begin sectioning of the first tissue block while the second tissue block is being hydrated.

A histologic tissue sample support device includes a tissue cassette, a frame, and a lid. The tissue cassette has a recess including a body with at least one side wall and a bottom wall and is formed of material that can be successfully sectioned in a microtome and is resistant to degradation from solvents and chemicals used to fix, process and stain tissue. The tissue cassette is movably coupled to the frame by a frame-cassette connector. The lid is coupled to a peripheral portion of the frame by a lid-frame connector. The lid and the tissue cassette are capable of moving from a first position to a second position with respect to the frame, and in the second position the bottom wall and at least a portion of the side wall extend beyond a bottom edge of the frame for sectioning in a microtome.

A histologic tissue sample support device includes a tissue cassette, a frame, and a lid. The tissue cassette has a recess including a body with at least one side wall and a bottom wall and is formed of material that can be successfully sectioned in a microtome and is resistant to degradation from solvents and chemicals used to fix, process and stain tissue. The tissue cassette is movably coupled to the frame by a frame-cassette connector. The lid is coupled to a peripheral portion of the frame by a lid-frame connector. The lid and the tissue cassette are capable of moving from a first position to a second position with respect to the frame, and in the second position the bottom wall and at least a portion of the side wall extend beyond a bottom edge of the frame for sectioning in a microtome.

A histologic tissue sample support device includes a tissue cassette, a frame, a lid, and a frame-cassette connector. The tissue cassette formed of a first material has a recess including a body with at least one side wall and a bottom wall and is formed of material that can be successfully sectioned in a microtome and is resistant to degradation from solvents and chemicals used to fix, process and stain tissue. The tissue cassette is movably coupled to the frame by a frame-cassette connector. The lid is coupled to the frame. The lid and the tissue cassette are capable of moving from a first position to a second position with respect to the frame, and in the second position the bottom wall and at least a portion of the side wall extend beyond a bottom edge of the frame for sectioning in a microtome.

A histologic tissue sample support device includes a tissue cassette, a frame, a lid, and a frame-cassette connector. The tissue cassette formed of a first material has a recess including a body with at least one side wall and a bottom wall and is formed of material that can be successfully sectioned in a microtome and is resistant to degradation from solvents and chemicals used to fix, process and stain tissue. The tissue cassette is movably coupled to the frame by a frame-cassette connector. The lid is coupled to the frame. The lid and the tissue cassette are capable of moving from a first position to a second position with respect to the frame, and in the second position the bottom wall and at least a portion of the side wall extend beyond a bottom edge of the frame for sectioning in a microtome.

The present disclosure relates to a mounting press for hot mounting a sample, comprising: a mounting cylinder for receiving the sample, having a main cylinder axis and a cylinder opening, the main cylinder axis extending inside the mounting cylinder and out through the cylinder opening, a sliding closure with a sliding carriage, an upper piston and a closing lever that is operatively connected to the upper piston, wherein the sliding carriage is configured so as to be displaceable in a direction transverse to the main cylinder axis, for example by means of the closing lever, and wherein in a position of use of the sliding carriage the upper piston can be driven to or into the cylinder opening of the mounting cylinder, wherein the closing lever has at least one open position and one closed position and can be transferred from the open position into the closed position, and wherein the closing lever cooperates with the upper piston such that the upper piston closes the cylinder opening when guiding the closing lever from the open position into the closed position when the sliding carriage is in the position of use.

The present disclosure relates to a mounting press for hot mounting a sample, comprising: a mounting cylinder for receiving the sample, having a main cylinder axis and a cylinder opening, the main cylinder axis extending inside the mounting cylinder and out through the cylinder opening, a sliding closure with a sliding carriage, an upper piston and a closing lever that is operatively connected to the upper piston, wherein the sliding carriage is configured so as to be displaceable in a direction transverse to the main cylinder axis, for example by means of the closing lever, and wherein in a position of use of the sliding carriage the upper piston can be driven to or into the cylinder opening of the mounting cylinder, wherein the closing lever has at least one open position and one closed position and can be transferred from the open position into the closed position, and wherein the closing lever cooperates with the upper piston such that the upper piston closes the cylinder opening when guiding the closing lever from the open position into the closed position when the sliding carriage is in the position of use.

Provided herein are methods of preserving a biological sample on a first substrate, the methods including: (a) disposing a biological sample on a first substrate; (b) delivering a spacer agent to the first substrate, wherein the spacer agent is applied around the biological sample on the first substrate, thereby generating a chamber around the biological sample; (c) delivering a mounting agent to the chamber; and (d) assembling the first substrate with a second substrate, thereby preserving the biological sample on the first substrate.

Provided herein are methods of preserving a biological sample on a first substrate, the methods including: (a) disposing a biological sample on a first substrate; (b) delivering a spacer agent to the first substrate, wherein the spacer agent is applied around the biological sample on the first substrate, thereby generating a chamber around the biological sample; (c) delivering a mounting agent to the chamber; and (d) assembling the first substrate with a second substrate, thereby preserving the biological sample on the first substrate.

Disclosed is plate or film for collecting and analyzing a sample. The plate or film includes a surface and a plurality of slices from the sample immobilized on the surface. Further, the plurality of slices are cut from the sample with equal thickness, and the plurality of slices are placed on the surface of the plate or film following their cutting order.