A foreign substance detection device includes a flow path unit through which a fluid is flown; an optical system configured to flatten a laser light from a laser source to be lengthened in a direction intersecting with a flow direction of the fluid; a laser light irradiation unit provided such that an optical path intersects with the flow direction and configured to irradiate the laser light into the flow path unit; a light detection unit which is provided on the optical path having passed through the flow path unit and includes light receiving elements arranged in a lengthwise direction of a transversal cross section of the optical path; a foreign substance detection unit configured to compare a signal level corresponding to intensity of light received by each light receiving element with a threshold value and configured to detect the foreign substances based on a comparison result.

A particle size distribution measuring device includes an actual spectrum obtaining unit obtaining an actual spectrum which is a light intensity spectrum; a non-target spectrum calculating unit that receives non-target particle size distribution data indicating a particle size distribution of a non-target particle group which is not a measurement target and which is accommodated in the cell and that calculates, on the basis of the non-target particle size distribution data, a non-target spectrum which is a light intensity spectrum to be obtained by irradiating the non-target particle group with light; a non-target spectrum removing unit that calculates a target spectrum which is a light intensity spectrum obtained by subtracting an influence of the non-target spectrum from the actual spectrum; and a target particle size distribution calculating unit that calculates the particle size distribution of the particle group which is the measurement target on the basis of the target spectrum.

A foreign substance detection device includes a flow path unit through which a fluid is flown; an optical system configured to flatten a laser light from a laser source to be lengthened in a direction intersecting with a flow direction of the fluid; a laser light irradiation unit provided such that an optical path intersects with the flow direction and configured to irradiate the laser light into the flow path unit; a light detection unit which is provided on the optical path having passed through the flow path unit and includes light receiving elements arranged in a lengthwise direction of a transversal cross section of the optical path; a foreign substance detection unit configured to compare a signal level corresponding to intensity of light received by each light receiving element with a threshold value and configured to detect the foreign substance based on a comparison result.

An air bubble measurement device is a device that measures the air bubbles moving in the liquid. The air bubble measurement device includes a measurement chamber that holds a liquid. The measurement chamber includes an introduction port to introduce the air bubbles in the liquid from a lower side and a transparent inclined surface that faces obliquely downward and is disposed at a position to which the air bubbles present inside the liquid move up. The transparent inclined surface includes a hydrophilic membrane. The hydrophilic membrane has a contact angle with water of 20 degrees or less. This structural arrangement allows for reducing an attachment of the air bubbles on the transparent inclined surface even when the air bubbles become small. This allows for reducing stay of the air bubbles on the transparent inclined surface and allows for accurately measuring the states of the air bubbles (that is, the size and quantity of the air bubbles).

Quantifying nanobubbles in solution includes combining an indicator with a fluid comprising nanobubbles to yield a first solution, bursting the nanobubbles in the first solution to yield a second solution, and assessing a difference between the first solution and the second solution to yield a concentration of the nanobubbles in the first solution, a concentration of reactive oxygen species in the first solution or the second solution, or both.

A sensor system for sensing contaminants within a fluid stream of a fluid system includes a sensor body and an arm extending from the sensor body to a distal end of the arm, a laser light source configured to direct a laser beam outwardly from an outlet of the sensor body, and a light sensor. A fiber optic light guide is disposed in the sensor body and extends from the light sensor to an inlet of the sensor body for directing light to the light sensor. A beam dump is positioned at the distal end opposite the laser light source to absorb at least a portion of the laser beam directed towards the distal end. A blocking member of the arm is disposed intermediate between the sensor body and the distal end and is configured to partially restrict a field of intake of light at the inlet.

A particle size distribution measuring device includes an actual spectrum obtaining unit obtaining an actual spectrum which is a light intensity spectrum; a non-target spectrum calculating unit that receives non-target particle size distribution data indicating a particle size distribution of a non-target particle group which is not a measurement target and which is accommodated in the cell and that calculates, on the basis of the non-target particle size distribution data, a non-target spectrum which is a light intensity spectrum to be obtained by irradiating the non-target particle group with light; a non-target spectrum removing unit 23 that calculates a target spectrum which is a light intensity spectrum obtained by subtracting an influence of the non-target spectrum from the actual spectrum; and a target particle size distribution calculating unit that calculates the particle size distribution of the particle group which is the measurement target on the basis of the target spectrum.

A method is provided for detecting one or more analytes in a sample. The method relies, in part, on the ability of functionalized particles added to the sample to partially or completely inhibit the transmission of electromagnetic radiation into and out of the sample through a detection surface in a reaction vessel containing the sample. In a microarray format, the invention can be used to screen millions, billions or more biological elements, such as an organism, cell, protein, nucleic acid, lipid, saccharide, metabolite, or small molecules. Methods, apparatuses and kits are described.

A method for observing a sample by lensless imaging, in which a sample is positioned between a laser diode and an image sensor, the laser diode being supplied with a supply current whose intensity is less than or equal to a critical value. This critical intensity is determined during preliminary operations, during which the intensity is initially greater than a laser threshold of the diode. By observing the image formed at the image sensor, the intensity is decreased until an attenuation of the interference images on the formed image is observed, the critical intensity corresponding to the intensity at which this attenuation is optimum.

An apparatus and method for testing dissolution properties of a drug, especially anti-inflammatory drugs administered by aerosol into the respiratory system. The apparatus shortens the time it takes for a drug to dissolve and thus provides for rapid testing of new drugs for quality control as well as for regulatory purposes. It is suitable for evaluating bioequivalence or to study the pharmacokinetics of drugs administered into the respiratory system. This method shortens dissolution times for testing a drug to about 10 and 20 minutes and thus provides for rapid testing.