A multiplex aptamer sensor platform for determining the concentration of a target analyte in sample. Aptamers are modified with redox-active molecule and selected to exhibit conformational change in the presence of target analyte, so that faradic discharge can be sampled at the electrode surface. Faradic discharge is converted to digital signal for calculation of the analyte concentration. The platform is attached to a test cartridge utilizing a vertical connection to a reader device. Sensor electrodes are manufactured using PCB techniques yet the platform is both accurate and commercially usable. No mixing, microfluidics or calibration are required.

A method for in vitro simulation and evaluation of platelet adhesion in blood-contacting medical devices is disclosed, including the following steps: (1) using a glycerin aqueous solution with a mass percentage concentration of 40% in an extracorporeal circulation circuit to simulate a viscosity and hydrodynamic characteristics of blood, and adding fluorescent particles with a diameter of 3 μm to 5 μm to the solution to simulate platelets; (2) after the solution circulates in the circuit for a specified time period, removing flow passage components of a tested device, and observing the deposition of the fluorescent particles on a blood-contacting surface inside the device by naked eyes and photographs; and (3) using laser-induced fluorescence (LIF) technique to apply laser light on a device surface deposited with the fluorescent particles and in contact with blood, and using charge-coupled device (CCD) camera imaging to photograph the aggregation and adhesion of laser-induced fluorescent particles.

A particle detecting device is provided. The particle detecting device includes an impactor, a resonator and a piezoelectric actuator. A gas containing a plurality of suspended particles is transported into the impactor and is impacted by the impactor for performing separation and screening based on different diameters of the suspended-particles. Moreover, screened and required-diameter particles from the impactor are collected by the resonator to detect a mass and a concentration of the screened and required-diameter particles. Thus, the air quality can be monitored anytime and anywhere.

A method for evaluating the functionality of a ceramic sensor for detecting soot, the sensor including two measurement electrodes exposable to an exhaust and spaced apart from one another, and an electrical resistance heating element. The method includes: activating the resistance heating element to heat up the sensor and to burn soot off the two measurement electrodes; then deactivating the resistance heating element; then waiting for a first predetermined time period and/or waiting until a signal that is received from the sensor and represents the sensor temperature reaches a first predefined value; then measuring a first variable representing the electrical resistance between the measurement electrodes; then evaluating the functionality of the sensor based on the first variable representing the electrical resistance between the measurement electrodes.

The invention generally provides systems and methods for particle detection for minimizing microbial growth and cross-contamination in manufacturing environments requiring low levels of microbes, such as cleanroom environments for electronics manufacturing and aseptic environments for manufacturing pharmaceutical and biological products, such as sterile medicinal products. In some embodiments, systems of the invention incorporate a housing having an outer surface being a first antimicrobial surface and a touchscreen being a second antimicrobial surface. In some embodiments, substantially all of the outer surfaces of the system are antimicrobial surfaces. In some embodiments, the first antimicrobial surface may comprise an Active Screen Plasma alloyed layer. In some embodiments, the housing may comprise a molded polymer substrate and a metal coating layer bonded to the molded polymer substrate such that at least some exterior surfaces of the housing are metal coated surfaces.

A sensor to detect solid particles of a target salt can include a support substrate, an adsorption layer, a sensing layer oriented between the support substrate and the adsorption layer, and an electrode pair in contact with the sensing layer and separated by the sensing layer. The adsorption layer can include an ion exchange medium formed of a first porous structured material functionalized with basic or acidic functional groups. The basic or acidic functional groups can remove an acid or base component from the target salt to form a free base or free acid, respectively, of the target salt. The sensing layer can include a second porous structured material functionalized to detect the free base or acid of the target salt by a change in conductivity.

An autonomous bioaerosol sampling and detection system and method adapted to provide real-time detection and identification of bio-organisms in aerosols without human intervention.

Aspects of the present disclosure involve systems, methods, and the like, for a fabrication of a particulate matter (PM) sensor that utilizes a capacitance sensor to detect sub-micrometer and nanoparticles in the respirable range of an environment. In one implementation, the capacitance sensor may comprise interdigitated electrodes between which a capacitance may be measured. PM deposited on the sensor may cause the capacitance between the electrodes to be altered and such a change in capacitance may be measured by the PM sensor. This measurement of the change in capacitance of the interdigitated capacitance sensor may therefore be correlated to the presence of sub-micrometer and nanoparticles in an environment. In one particular implementation, the PM sensor may further include a micro-heater circuit, a readout circuit, and an interface connecting the readout circuit to the micro-heater/capacitance sensor of the PM sensor.

A method for evaluating a fluid to reduce a deposition of a solid within a fractured subterranean formation may include obtaining information about materials inside of a testing vessel, where the materials are designed to be representative of the fractured subterranean formation. The method may also include providing a fluid that flows through the materials inside the testing vessel for a period of time, where the testing vessel is subjected to conditions designed to be representative of downhole conditions of the fractured subterranean formation. The method may also include evaluating the material to characterize the deposition of the solid on at least some of the materials after the period of time.

A particulate matter (PM) sensor circuit arrangement includes a PM sensor. The sensor includes, integral therewith, a PM sensor resistor, a resistive temperature device (RTD) resistor, and a heater resistor. The PM sensor includes four terminal pins, of which a) a first terminal pin is connected to one terminal of the PM sensor resistor; a second terminal pin is connected to one terminal side of said RTD resistor; c) a third terminal pin being connected to one terminal of a heater resistor; and d) a fourth common terminal pin is connected to respective opposite terminals of the PM sensor resistor, RTD resistor, and heater resistor to the first, second, and third terminal pins. The fourth common terminal pin is operationally connected to a boost or voltage supply and the first pin is connected to a low side line.