Disclosed herein include systems, devices, and methods for cytometric bead array (CBA) analysis. After receiving user selections of a reporter fluorescent dye and clustering fluorescent dyes, gates for CBA event data corresponding to analytes in samples and standard curves for the analytes can be determined. Concentrations of the analytes in the samples can be determined using the standard curves.

Methods and systems for determining a risk level of a neurodegenerative disease by analyzing expression levels of a plurality of RNA transcripts of a sample. The method uses an imager, a magnet, a light source, and a flow cell that includes a functionalized surface having a plurality of capture probes. Each of the plurality of capture probes is configured to bind molecules in the sample comprising one of the plurality of RNA transcripts. The method includes the following steps. Binding molecules in the sample to a magnetic particle. Directing the molecules to the functionalized surface using the magnet. Binding each specific molecule of the molecules to one of the plurality of capture probes configured to bind the RNA transcript of the specific molecule. Directing a light beam from the light source at bound molecules bound on each of the plurality of capture probes. Capturing light from the bound molecules. Determining a quantity of the bound molecules bound on each of the plurality of capture probes based on the captured light. Determining a plurality of expression levels corresponding to the plurality of RNA transcripts based on the quantity of the bound molecules bound on each of the plurality of capture probes configured to bind each of the plurality of RNA transcript. Calculating a risk of the neurodegenerative disease based on the plurality of expression levels of the plurality of RNA transcripts.

A particulate matter measuring apparatus including an inlet for introducing air, a cyclone means fluidly connected to the inlet, the cyclone means adapted to remove particles of a predetermined size from the air, a particle detector to detect particulate matter in the air and a pump to move the air from the inlet, through the cyclone means and through the particle detector, wherein the particle detector has a laser diode to shine laser light through the air and a detector angled at between 115 to 140 relative to the direction of the laser light to detect an amount of laser light scattered by particulate matter in the air.

Systems, methods, and computer-program products for fluid analysis and monitoring are disclosed. Embodiments include a removable and replaceable sampling system and an analytical system connected to the sampling system. A fluid may be routed through the sampling system and data may be collected from the fluid via the sampling system. The sampling system may process and transmit the data to the analytical system. The analytical system may include a command and control system to receive and store the data in a database and compare the data to existing data for the fluid in the database to identify conditions in the fluid. Fluid conditions may be determined using machine learning models that are generated from well-characterized known training data. Predicted fluid conditions may then be used to automatically implement control processes for an operating machine containing the fluid.

Systems and methods to calibrate an imaging sensor may include an enclosure with a controlled environment, a light source illuminating the environment, and a particle source emitting desired particles at desired concentrations into the environment. An imaging sensor, which may be associated with an aerial vehicle, may be placed within the enclosure, and the imaging sensor may capture imaging data within the controlled environment. In addition, the imaging data may be processed to determine current spectral characteristics of the imaging sensor. Based on the environment, light, and particle properties within the environment, the imaging sensor may be calibrated to exhibit nominal or desired spectral characteristics.

A dual-passage air quality detection device includes a housing, an air quality detection module, a fan, and a main control PCB (printed circuit board). The air quality detection module includes two passages, two laser modules and two photodiodes therein. The fan includes two fans. One of the passages is communicated with the inside of the vehicle, and the other of the passages is communicated with the outside of the vehicle to form two independent air passages for detection. Each of the passages corresponds to one fan for independent sampling, not affecting each other.

Device for optically detecting smoke and implementing thereof. Apparatus and methods for detecting the presence of smoke in a small, long-lasting smoke detector are disclosed. Specifically, the present disclosure shows how to build a very compact housing around the smoke detector while keeping the reflections from the housing structure to a very low value while satisfying all the other peripheral needs of fast response to smoke and preventing ambient light. This allows very small measurements of light scattering of the smoke particles to be reliable in a device resistant to the negative effects of dust. In particular, geometrical optical elements, e.g., cap and optical defection elements, are disclosed.

A method for observation of a sample, the sample comprising microorganisms immersed in a nontransparent culture medium, the culture medium being favorable to the development of the microorganisms, the sample being arranged between a light source and an image sensor, the method comprising: a) illuminating the sample with the light source, the light source emitting light propagating along an axis of propagation; b) acquiring an image of the sample by the image sensor; c) from the image acquired, characterization of the microorganisms; the method being characterized in that: the culture medium extends, parallel to the axis of propagation, to a thickness of less than 500 m.

A low energy particle detection device comprises alight source, multiple photodetectors positioned at different scattering angles, and a microcontroller for computing a total mass concentration of fine and ultrafine particles and a mass fraction of ultrafine particles to fine particles in an incoming air particle airflow based on the ratio of the readings from the multiple photodetectors. The optical particle detection device also can determine surface area concentration of the air particle sample and the associated lung deposited surface area (LDSA) to measure and improve estimates of air quality.

A method of monitoring a solid component of a reactor feed stream in a polymer production system, comprising (a) measuring a turbidity of the reactor feed stream, wherein the reactor feed stream comprises a solid component of a polymerization catalyst system, and (b) translating the turbidity of the reactor feed stream into a concentration of the solid component in the reactor feed stream. A method of monitoring a solid component of a reactor feed stream in a polymer production system, comprising (a) measuring a turbidity of a precontactor feed stream, wherein the precontactor feed stream comprises a solid component of a polymerization catalyst system, and (b) translating the turbidity of the precontactor feed stream into a concentration of the solid component in a precontactor effluent stream, wherein the precontactor effluent stream comprises the reactor feed stream.