The present invention relates to a method for measuring circulating cells in superficial body fluids by means of high-frequency-based device. The method can be used for detecting circulating cells in the fluids of an individual without the necessity of extracting a sample of the individual, being useful as a diagnostic tool and for monitoring the effectiveness of a treatment administered to an individual suffering from a viral, protozoal, fungal and/or bacterial disease.

The invention in some aspects relates to high throughput methods and devices for evaluating mechanical, morphological, kinetic, rheological or hematological properties of cells, such as blood cells under regulated gas conditions. In some aspects, the invention relates to methods and devices for diagnosing and/or characterizing a condition or disease in a subject by measuring a property of a cell from the subject, under controlled gas conditions.

A fluid sample is analysed in-line by OCT techniques. The density, size, velocity and other attributes of particles present in a fluid, oil, for example, that is flowing through a conduit.

Approaches for determining the delivery success of a particle, such as a drug particle, are disclosed. A system for monitoring delivery of particles to biological tissue includes a volume, an optical component, a detector, and an analyzer. The volume comprises a space through which a particle can pass in a desired direction. The optical component is configured to provide a measurement light. The detector is positioned to detect light emanating from the particle in response to the measurement light. The detected light is modulated as the particle moves along a detection axis. The detector is configured to generate a time-varying signal in response to the detected light. The analyzer is configured to receive the time-varying signal and determine a delivery success of the particle into a biological tissue based upon characteristics of the time-varying signal.

Disclosed is an apparatus and method for providing asymmetric oscillations to a container. The container may include a fluid, a particle, and/or a gas. A vibration driver attached to the container provides asymmetric oscillations. A controller connected to the vibration driver controls an amplitude, frequency, and shape of the asymmetric oscillations. An amplifier amplifies the asymmetric oscillations in response to the controller. A sensor disposed on the vibration driver provides feedback to the controller.

Disclosed is an apparatus and method for providing asymmetric oscillations to a container. The container may include a fluid, a particle, and/or a gas. A vibration driver attached to the container provides asymmetric oscillations. A controller connected to the vibration driver controls an amplitude, frequency, and shape of the asymmetric oscillations. An amplifier amplifies the asymmetric oscillations in response to the controller. A sensor disposed on the vibration driver provides feedback to the controller.

A device and method for measuring precipitation, in particular snowfall or hail, which has a measuring chamber for receiving a precipitation particle, at least one light source for radiating the measuring chamber with light, and at least one sensor for sensing an intensity of the light radiating through the measuring chamber. At least two measurement areas, which are arranged one below the other, are provided in the measuring chamber, and the intensity of the light radiating through each of the measurement areas can be detected separately.

A method and system for capturing images of a liquid sample flowing through a field of view of an imaging device that can include stepping a focus mechanism of the imaging device through a plurality of focus values and capturing a plurality of images of the sample at each of the plurality of focus values as the sample flows through the field of view of the imaging device. In this way, image capture can proceed before a focus value has been determined and capture images that are in focus can be used for further processing subsequently.

A microfluidic particle analysis device comprising an inlet with an inlet manifold providing parallel fluid communication with a bypass channel and a measuring channel having a sensor system for detecting a particle, wherein the angle of the measuring channel relative to the main flow direction is in the range of 0 to 60, and wherein the angle of the bypass channel relative to the main flow direction is in the range of 0 to 60. The present invention also relates to a method of using the device microfluidic particle analysis.

The invention describes a laser sensor module (100) which is adapted to detect or determine at least two different physical parameters by means of self-mixing interference by focusing a laser beam to different positions. Such a laser sensor module (100) may be used as an integrated sensor module, for example, in mobile devices (250). The laser sensor module (100) may be used as an input device and in addition as a sensor for detecting physical parameters in an environment of the mobile communication device (250). One physical parameter in the environment of the mobile communication device (250) may, for example, be the concentration of particles in the air (air pollution, smog . . . ). The invention further describes a related method and computer program product.