G01N2015/1027

2D nanoparticle motion sensing methods and structures

A method, structure and system for capacitive sensing is provided. The structure includes: one or more first conductive lines arranged in a first arrangement in relation to a first substrate, one or more second conductive lines connected arranged in a second arrangement in relation to a second substrate, one or more first vias embedded on the first substrate and connecting one or more first electrodes to each respective one of the one or more first conductive lines; and one or more second vias embedded on the second substrate and connecting the one or more second electrodes to each respective one of the one or more second conductive lines, where the one or more first conductive electrodes and the second one or more electrodes are parallel and overlapping with respect to one another, and, where i) the first conductive electrodes and ii) the second conductive electrodes form a two-dimensional configuration.

Method and apparatus for image processing and visualization for analyzing cell kinematics in cell culture

Disclosed herein are methods for analyzing cell kinematics in a nucleated cell culture from a time-series sequence of multiple fluorescence microscopic images of the nucleated cell culture. The method includes the steps of, (a) identifying every cell nucleus in each fluorescence microscopic image; (b) identifying every cell cluster using the cell nuclei identified in the step (a); and (c) tracking the cells and/or cell clusters using the cell nuclei and cell clusters identified for the fluorescence microscopic images in steps (a) and (b) respectively.

OPTICAL PARTICLE SENSOR MODULE

A laser sensor module for detecting a particle density of small particles with a particle size between 0.05 ?m and 10 ?m includes a first laser configured to emit a first measurement beam, a second laser configured to emit a second measurement beam, and an optical arrangement configured to focus the first measurement beam to a first measurement volume and to focus the second measurement beam to a second measurement volume. The optical arrangement includes a first numerical aperture and a second numerical aperture arranged to detect a predetermined minimum particle size. The laser sensor module further includes a first detector configured to determine a first self-mixing interference signal of a first optical wave, a second detector configured to determine a second self-mixing interference signal of a second optical wave, and an evaluator.

FLOW CYTOMETERY SYSTEM WITH FLUIDICS CONTROL SYSTEM
20190285536 · 2019-09-19 ·

A system, method, and apparatus are provided for flow cytometry. In one example, the flow cytometry system includes dual laser devices and dual scatter channels to measure velocity of particles in a core stream of sample fluid. The total flow rate of the sample fluid and the sheath fluid around the sample fluid is controlled, and thus held constant, by a feedback control system controlling a vacuum pump based on differential pressure across ends of a flow channel in the flow cell.

Device for real time analysis of particles suspended in a fluid and method for the analysis of said particles

The present invention refers to a device for the analysis of a particle comprising an analysis chamber adapted to contain a positioning fluid. A parameter of the particle suspended in the positioning fluid is detected by means of a detection and control unit. A positioning unit, during a particle analysis operation, is activated and deactivated on the basis of the detected parameter of the particle. The detection and control unit can activate the at least one positioning unit so as to generate a temporary positioning flow in the positioning fluid, such that said temporary positioning flow acts directly on the particle and drives the position of the particle so as to move it into a predefined position in the analysis chamber. The detection and control unit can also deactivate the at least one positioning unit when the particle to be analyzed is in the predefined position, such that the positioning fluid is at rest.

DEVICE AND METHOD FOR MEASURING THE CONCENTRATION, SIZE AND ZETA POTENTIAL OF NANOPARTICLES IN LIQUIDS IN SCATTERED LIGHT MODE AND IN FLUORESCENCE MODE
20190277743 · 2019-09-12 · ·

The invention relates to a device and method for measuring the concentration, size and zeta potential of nanoparticles in liquids in scattered light mode and fluorescence mode, comprising the following features: a) a sample (28) is irradiated from above by a laser (1) via a beamsplitter (14) and an adjustable-focus liquid lens (9), and the reflected beam of light is deflected by the same beamsplitter (14) and a further liquid lens (8) onto a detector (5), and analysed; b) to observe the fluorescent light, a fluorescence filter (19) is connected in the convergent beam path between the liquid lens (8) and the detector (5), to increase the distance between the scattered light plane (31) and the fluorescence plane (30); and c) to control the measurement process, a particle tracking program, an optical control unit (15) and a display (2) with a touch screen are used.

2D NANOPARTICLE MOTION SENSING METHODS AND STRUCTURES
20190277789 · 2019-09-12 ·

A method, structure and system for capacitive sensing is provided. A system includes: a two-dimensional electrode structure, wherein the two-dimensional sensing structure includes a channel for capacitive sensing, at least one integrated circuit connected to the two dimensional sensing structure and configured to mitigate external interference associated with the capacitive sensing by i) receiving a input signal from the two-dimensional electrode structure or ii) providing a select signal to the two-dimensional structure, and a data acquisition device connected to the two-dimensional electrode structure via the integrated circuit configuration and configured to receive an output signal from the integrated circuit.

2D NANOPARTICLE MOTION SENSING METHODS AND STRUCTURES
20190277677 · 2019-09-12 ·

A method, structure and system for capacitive sensing is provided. The structure includes: one or more first conductive lines arranged in a first arrangement in relation to a first substrate, one or more second conductive lines connected arranged in a second arrangement in relation to a second substrate, one or more first vias embedded on the first substrate and connecting one or more first electrodes to each respective one of the one or more first conductive lines; and one or more second vias embedded on the second substrate and connecting the one or more second electrodes to each respective one of the one or more second conductive lines, where the one or more first conductive electrodes and the second one or more electrodes are parallel and overlapping with respect to one another, and, where i) the first conductive electrodes and ii) the second conductive electrodes form a two-dimensional configuration.

Simple Sperm Test Kit, System, and Method for Performing Simple Test on Sperm
20190265223 · 2019-08-29 ·

A simple sperm test kit 10 for performing a simple sperm test has a substrate 20 capable of being placed over a camera 30 of an information terminal 11, a recess 21 for containing semen A provided in the surface of the substrate 20, a cover 22 that covers the recess 21 for allowing external light to enter the recess 21, and a lens 23 provided within the substrate 20 on the lower side of the recess 21 for magnifying the semen A in the recess 21 and projecting an image on the back side of the substrate 20.

SYSTEM FOR DETERMINING THE SHAPE OF PARTICLES IN MOTION USING AN EVENT-BASED CAMERA
20240169577 · 2024-05-23 ·

A method for measuring attributes of a particle in motion comprises observing a region of interest with an event-based sensor oriented such that lines of a pixel array of the sensor lie across an expected trajectory of the particle (P) through the region of interest; defining two reference lines of pixels (R1, R2) separated by a spatial distance (D); sampling a first group of events produced by a first of the two reference lines; sampling a second group of events produced by the second of the two reference lines; determining a temporal distance (T) between the second and first groups of events; and providing a longitudinal speed factor (vy) of the particle based on the spatial distance and the temporal distance. The particles have a size spanning multiple adjacent pixels in a line, and the method further comprises analyzing one of the first and second groups of events over multiple time steps in order to produce an outline of the particle in space-time coordinates (x, t) including spatial components based on positions of event-triggered pixels in the lines and temporal components based on the time steps; and converting the space-time coordinates of the outline to spatial coordinates (x, y) by multiplying the time steps (t) of the space-time coordinates by the longitudinal speed factor (vy).