Described are various embodiments of methods, devices, systems and kits for magnetic levitation-based separation of mixtures or populations of particles that include various types of particles. Some embodiments of such methods, devices, systems and kits are useful for magnetic levitation-based separation of mixtures or populations of cells that include various cell types. Some other embodiments of the described methods, devices, systems and kits are useful for magnetic levitation-based separation of mixtures or population of cellular or mixtures or population of biological molecules.

A device and method for detecting particles by using electrical impedance measurement, in particular, relating to an improved electrical impedance measurement microfluidic chip and an improved particle detection method. The device comprises a sample injection part, a main channel (4) and an electrical impedance detection part. By means of said device and method, the present invention can accurately distinguish, detect and count different particles.

This disclosure provides methods and systems for classifying biological particles, e.g., blood cells, microbes, circulating tumor cells (CTCs). Using impedance flow cytometry, such as multi-frequency impedance cytometry, in conjunction with supervised machine learning, the disclosed methods and systems demonstrated improved accuracy in classifying biological particles.

An apparatus including a fluidic input and a die including a microfluidic chamber, may receive a biologic sample. The microfluidic chamber may include a foyer to contain a portion of the biologic sample, and an inlet impedance-based sensor to detect passage of a cell of the biologic sample into the foyer. A target nozzle may eject a first volume, corresponding with a target concentration of cells of the biologic sample. A spittoon nozzle may eject a second volume of the portion of the biologic sample into a spittoon location. An output impedance-based sensor may be disposed within a threshold distance of the target nozzle to detect passage of a cell of the biologic sample into the target nozzle. Moreover, the apparatus may include circuitry to control firing of the target nozzle and the spittoon nozzle based on signals received from the inlet impedance-based sensor and the output impedance-based sensor.

The present technology relates to systems and associated methods for measuring properties of particles in a solution. In one or more embodiments, a particle measurement system is configured to generate a reference signal, communicate the reference signal across a plurality of resistors and overlapping pairs of electrodes that define detection regions for particulates traveling through a microchannel, and measure various properties of the particles based on detecting changes in the communicated reference signal.

The present invention relates to a screen-printing paste composition for producing an electrical conductor arrangement, which screen-printing paste composition comprises particulate noble metal, comprising platinum and palladium, metal oxides, and organic binders and/or solvents, the proportion of the metal oxides in the screen-printing paste composition being 5 to 15 wt. %, based on the total amount of platinum and metal oxides. Suitable screen-printing paste compositions can be processed to form composite products by means of application to a substrate, subsequent drying and baking, which composite products can be used, for example, in particle sensors or heating devices. The particle sensors and heating devices thus produced are characterized by improved adhesion to the substrate at high temperatures and by conductivity, and demonstrated very good reproducibility of the electrical resistance in different production batches.

An exemplary mobile impedance-based flow cytometer is developed for the diagnosis of sickle cell disease. The mobile cytometer may be controlled by a computer (e.g., smartphone) application. Calibration of the portable device may be performed using a component of known impedance value. With the developed portable flow cytometer, analysis may be performed on two sickle cell samples and a healthy cell sample. The acquired results may subsequently be analyzed to extract single-cell level impedance information as well as statistics of different cell conditions. Significant differences in cell impedance signals may be observed between sickle cells and normal cells, as well as between sickle cells under hypoxia and normoxia conditions.

The present disclosure provides a microbead and a method for preparing the same. Also provided is a method for detecting and analyzing biomolecules in sample by using element analysis.

Magnetic chip detectors and associated for detecting metallic chips in engine fluid of an engine are provided. A magnetic chip detector includes first and second magnetic chip capture zones. The first magnetic chip capture zone includes a first electrically conductive terminal spaced apart from a second electrically conductive terminal to define a first chip-receiving gap therebetween. The second magnetic chip capture zone includes a third electrically conductive terminal and either the second electrically conductive terminal or a fourth electrically conductive terminal to define a second chip-receiving gap therebetween. The magnetic chip detector includes an electric circuit including both the first chip-receiving gap and the second chip-receiving gap. The electric circuit provides an output indicative of a chip detection by one or both of the first magnetic chip capture zone and the second magnetic capture zone.

Disclosed are a sample analysis apparatus and a sample analysis method. The method includes: obtaining a leukocyte measurement mode for a test sample, the method having a plurality of leukocyte measurement modes, each of which includes at least a reaction time, and different leukocyte measurement modes having different reaction times; determining a reaction time for the current sample to be tested; controlling the sample to be tested to react with the reagent, to prepare a test sample for detecting leukocytes; and controlling to detect the test sample for detecting leukocytes, to obtain detection data of leukocyte classification.