A method for detecting the quality of cell culture fluid based on Raman spectral measurement. The method comprises the following steps: collecting cell culture fluid; collecting, processing and analyzing a Raman spectral signal; measuring an original Raman spectral signal of a metabolite in the cell culture fluid using a Raman spectra technique; determining whether the original Raman spectral signal is qualified, and carrying out data signal processing on the qualified original Raman spectral signal to obtain analyzable signals; and then carrying out difference statistical analysis on the analyzable signals to obtain difference signals; carrying out modeling using the difference signals; classifying the difference signals using a support vector machine; and distinguishing the spectral signals of normal and abnormal cell culture fluid to obtain a quality result of the cell culture fluid. Difference signals in cell culture fluid are detected by means of Raman spectra to detect the quality of the cell culture fluid, thereby achieving the purpose of non-invasive evaluation of a cell growth state; and the method is convenient, effective and low-cost, and can achieve large-scale industrialization and streamlining.

The present disclosure relates to methods and apparatus for measuring of multiple physiological properties of biological samples, such as measuring biological flux.

The present disclosure relates to methods and apparatus for measuring of multiple physiological properties of biological samples, such as measuring biological flux.

The present invention provides self-contained systems for performing an assay for determining a chemical state, the system including a stationary cartridge for performing the assay therein, at least one reagent adapted to react with a sample; and at least one reporter functionality adapted to report a reaction of the at least one reagent with said sample to report a result of the assay, wherein the at least one reagent, the sample and the at least one reporter functionality are contained within the cartridge.

The present invention provides self-contained systems for performing an assay for determining a chemical state, the system including a stationary cartridge for performing the assay therein, at least one reagent adapted to react with a sample; and at least one reporter functionality adapted to report a reaction of the at least one reagent with said sample to report a result of the assay, wherein the at least one reagent, the sample and the at least one reporter functionality are contained within the cartridge.

An integrated semiconductor device for manipulating and processing bio-entity samples and methods are described. The device includes a lower substrate, at least one optical signal conduit disposed on the lower substrate, at least one cap bonding pad disposed on the lower substrate, a cap configured to form a capped area, and disposed on the at least one cap bonding pad, a fluidic channel, wherein a first side of the fluidic channel is formed on the lower substrate and a second side of the fluidic channel is formed on the cap, a photosensor array coupled to sensor control circuitry, and logic circuitry coupled to the fluidic control circuitry, and the sensor control circuitry.

A method of optical analysis comprises receiving light at an optical spectrometer module from a light source, distributing the received light into two or more light beams with a light distribution component of the optical spectrometer module, concurrently exposing each of a reference and one or more test samples to one of the two or more light beams, and concurrently measuring a property of the light associated with each of the reference sample and one or more test samples with a corresponding detector.

An apparatus and method of use are provided; the apparatus having at least a degasser, a hollow core fiber HCF, an optical mechanism, a detector, and circuitry. The degasser enables gasses to permeate out of a liquid into the degasser interior. The propagator establishes a low-pressure area that helps to pull the gas from the degasser interior into the HCF interior, where the optical mechanism delivers electromagnetic radiation EMR that interacts with the gas. The detector determines EMR absorption, producing output signals which are sent to the circuitry. Circuitry controls the optical mechanism and analyzes the output signals to quantify the concentration of gas in the HCF and in the liquid.

A sensing rack includes a base, a plurality of sensing mechanisms, and a plurality of displaying elements. The base includes a plurality of accommodating spaces. The sensing mechanisms are disposed in the base, and each of the sensing mechanisms correspond to each of the accommodating spaces and includes a light sensing component and a light blocking element. A light sensing component includes a light emitting element and a light receiving element. The light blocking element is drivable to move between the light emitting element and the light receiving element so as to control a light of the light emitting element to enter the light receiving element or not. Each of the displaying elements is electrically connected with the light receiving element of each of the sensing mechanisms and is for displaying the light of each of the light emitting elements entering the light receiving element or not.

A sensing rack includes a base, a plurality of sensing mechanisms, and a plurality of displaying elements. The base includes a plurality of accommodating spaces. The sensing mechanisms are disposed in the base, and each of the sensing mechanisms correspond to each of the accommodating spaces and includes a light sensing component and a light blocking element. A light sensing component includes a light emitting element and a light receiving element. The light blocking element is drivable to move between the light emitting element and the light receiving element so as to control a light of the light emitting element to enter the light receiving element or not. Each of the displaying elements is electrically connected with the light receiving element of each of the sensing mechanisms and is for displaying the light of each of the light emitting elements entering the light receiving element or not.