Systems and methods for measuring the isotope ratio of one or more gaseous oxides produced during combustion of drugs, pharmaceuticals, or medicines aiming to detect counterfeit drugs, pharmaceuticals, or medicines based on comparison of the isotopic composition of the tested drugs, pharmaceuticals, or medicines with the isotopic composition of the authentic products.

In the additive manufacturing process, a monitored or controlled mixture of materials is deposited to form an additive manufactured product by delivering the mixture of materials through a material flow path while using an excitation source to introduce electromagnetic energy into the material flow path using a circuit element having inductive or capacitive reactance disposed adjacent the material ejecting orifice. The excitation source produces an electromagnetic field condition within the material flow path that is responsive to at least one of the permeability and permittivity properties of a space within the material flow path. A sensing means coupled electrically or magnetically to the excitation means is responsive to the electromagnetic field condition and provides at least one control parameter based on the electromagnetic field condition that may be used to control the composition of the mixture of materials by adjusting proportions of constituent materials.

A device may receive information identifying results of a spectroscopic measurement performed on an unknown sample. The device may determine a decision boundary for a quantification model based on a configurable parameter, such that a first plurality of training set samples of the quantification model is within the decision boundary and a second plurality of training set samples of the quantification model is not within the decision boundary. The device may determine a distance metric for the spectroscopic measurement performed on the unknown sample relative to the decision boundary. The device may determine a plurality of distance metrics for the second plurality of training set samples of the quantification model relative to the decision boundary. The device may provide information indicating whether the spectroscopic measurement performed on the unknown sample corresponds to the quantification model.

The present invention provides a system for measuring concentrations of trace gases in gas mixtures using an absorption spectroscopy method. The system comprising: a resonant optical cavity containing a gas mixture, a continuous-wave external cavity laser, a detector system for measuring an absorption of laser light by the gas in the resonant optical cavity, wherein the ratio of the round-trip length of the external cavity laser to the round-trip length of the resonant optical cavity or its inverse value is between N0.2 and N+0.2, where N is a positive integer number.

Systems and methods for measuring the isotope ratio of one or more gaseous oxides produced during combustion of drugs, pharmaceuticals, or medicines aiming to detect counterfeit drugs, pharmaceuticals, or medicines based on comparison of the isotopic composition of the tested drugs, pharmaceuticals, or medicines with the isotopic composition of the authentic products.

A device may receive information identifying results of a spectroscopic measurement performed on an unknown sample. The device may determine a decision boundary for a quantification model based on a configurable parameter, such that a first plurality of training set samples of the quantification model is within the decision boundary and a second plurality of training set samples of the quantification model is not within the decision boundary. The device may determine a distance metric for the spectroscopic measurement performed on the unknown sample relative to the decision boundary. The device may determine a plurality of distance metrics for the second plurality of training set samples of the quantification model relative to the decision boundary. The device may provide information indicating whether the spectroscopic measurement performed on the unknown sample corresponds to the quantification model.

The present invention provides systems and methods for measuring the isotope ratios of one or more trace gases based on optical absorption spectroscopy methods. The system includes an optical cavity containing a gas. The system also includes a laser optically coupled with the optical cavity, and a detector system for measuring absorption of laser light by the gas in the cavity.

The present invention provides a system for measuring concentrations of trace gases in gas mixtures using an absorption spectroscopy method. The system comprising: a resonant optical cavity containing a gas mixture, a continuous-wave external cavity laser, a detector system for measuring an absorption of laser light by the gas in the resonant optical cavity, wherein the ratio of the round-trip length of the external cavity laser to the round-trip length of the resonant optical cavity or its inverse value is between N0.2 and N+0.2, where N is a positive integer number.

A fiber optic sensor arrangement is disclosed that includes a plurality of optical fiber based sensor elements, the sensor elements configured to modify an associated optical carrier signal in accordance with changes in a sensed quantity at a location of the sensor element and a phase modulation arrangement for phase modulating each optical carrier signal in accordance with respective uncorrelated pseudorandom binary sequence signals. The sensor arrangement also includes an interferometer module for receiving each of the phase modulated optical carrier signals, the interferometer module operable to convert a change in the phase modulated optical carrier signals to a change in optical intensity of the corresponding optical carrier signal to generate a combined modulated optical intensity signal, an optical intensity detector for measuring the combined modulated optical intensity signal and generating a time varying electrical detector signal and an analog to digital convertor to convert the time varying electrical detector signal to a time varying digitized detector signal. Also included in the sensor arrangement is a decorrelator arrangement for decorrelating the time varying digitized detector signal against the respective uncorrelated pseudorandom binary sequence corresponding to each of the optical carrier signals to recover each of the modulated optical carrier signals and a demodulator for demodulating each of the modulated optical carrier signals to recover the respective optical carrier signal to determine the changes in the sensed quantity at the location of the sensor element.

The present invention provides systems and methods for measuring the isotope ratios of one or more trace gases based on optical absorption spectroscopy methods. The system includes an optical cavity containing a gas. The system also includes a laser optically coupled with the optical cavity, and a detector system for measuring absorption of laser light by the gas in the cavity.