A method for screening a prostate cancer patient, which may analyze whether or not androgen receptor (AR)-targeted therapy is applicable to the prostate cancer patient, through optical image analysis of circulating tumor cells and an AR variant.

Certain implementations of the subject matter can be implemented as a method of screening demulsifiers for live crude oil-water emulsions. A live emulsion of a hydrocarbon sample and a water sample is flowed through a capillary viscometer. The live emulsion includes dissolved gases retrieved from a hydrocarbon-carrying reservoir. While flowing the live emulsion through the capillary viscometer, a demulsifier sample is flowed through the capillary viscometer. The demulsifier sample causes breakdown of the live emulsion. Using the capillary viscometer, change in a viscosity of the live emulsion over time resulting from the breakdown of the live emulsion due to the demulsifier sample is measured. Multiple images of the breakdown of the live emulsion over time are captured. A strength of the live emulsion is classified based, in part, on the change in the viscosity of the live emulsion over time and on the plurality of images.

The present disclosure relates to devices and methods configured to perform drug screening on cells. At least one embodiment relates to a lens-free device for performing drug screening on cells. The lens-free device includes a substrate having a surface. The lens-free device also includes a light source positioned to illuminate the cells, when present, on the substrate surface with a light wave. The lens-free device further includes a sensor positioned to detect an optical signal caused by illuminating the cells. The substrate surface includes a microelectrode array for sensing an electrophysiological signal from the cells.

Described embodiments include a system for inspecting a tubular device that includes an outer surface and a spatially-periodic supporting structure beneath the outer surface. The system includes an imaging device, configured to acquire an image of a reflection of light from the outer surface, and a processor, configured to ascertain a spatial frequency of the supporting structure by processing the image. Other embodiments are also described.

Near InfraRed NIR technology, including NIR cameras and detectors, is used to accurately identify moisture content and the specific locations of the moisture on an entire surface of a veneer sheet or other wood product. Based on the identified moisture content for a given wood product, one or more actions are taken with respect to wood product to ensure the wood product is put the most efficient, effective, and valuable use.

Near InfraRed NIR technology, including NIR cameras and detectors, and machine learning methods and systems, including one or more Machine Learning (ML) based moisture level detection models, are used to accurately identify moisture content and the specific locations of the moisture on an entire surface of a veneer sheet or other wood product and provide moisture level prediction data for the veneer sheet or other wood product. Based on the moisture level prediction data for a given wood product, one or more actions are taken with respect to wood product to ensure the wood product is put to the most efficient, effective, and valuable use.

Near InfraRed NIR technology, including NIR cameras and detectors, and one or more visual cameras are used to generate superimposed image data representing a visual/NIR composite image of wood product and correlating moisture levels with physical features of the surfaces of the wood product. By analyzing the visual/NIR composite image represented by superimposed image data, moisture pockets near an open physical feature that, absent the presence open physical feature would be a problem, can be identified and ignored. Based on the identified moisture levels at various locations in a given wood product, and the proximity of physical features to the identified moisture locations, one or more actions are taken with respect to wood product to ensure the wood product is put to the most efficient, effective, and valuable use.

An improved DNA sequencing system comprising a DNA sample holder residing on a stacked BSI global shutter image sensor illuminated by a pulsed laser for fluorescent illumination detection. The pulsed laser has on and off periods wherein during the laser on period a Fluorophore tag attached to a DNA sample is excited to produce fluorescence emission while the imaging system captures no illumination and during the off period the global shutter imaging system captures persistent fluorescent emission from the DNA sample and reads out an imaging signal.

A sample observation device includes a flow cell in which a fluid containing samples flows, an irradiation unit configured to irradiate the samples flowing in the flow cell with planar light, an image formation unit having an observation axis inclined with respect to an irradiation surface for the planar light, and configured to form an image of observation light generated in the sample due to the irradiation with the planar light, a two-dimensional imaging element configured to capture a light image including at least a cross section of the fluid among light images according to the observation light formed by the image formation unit, and outputs image data, and an analysis unit configured to analyze a light intensity profile of the sample in a flow direction of the fluid on the basis of the image data.

A system for visualizing melanin present in tissue can include an imaging system to record a signal based on a presence of melanin in tissue and a display device to display an image based on the signal. A first laser source can emit a Stokes pulse train and a second laser source can emit a pump pulse train. Both the first laser source and the second laser source comprise a tunable center wavelength or frequency. An energy difference between a frequency of the Stokes pulse train and a frequency of the pump pulse train is from 1750 cm.sup.1 to 2250 cm.sup.1. The Stokes and the pump pulse train overlap in space and time. A scanning mechanism focuses the combined Stokes pulse train and pump pulse train within the tissue and scans across the tissue. A detector detects the signal based on a presence of melanin within the tissue.